Optimizing drug delivery to brain tumors

THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

Partition coefficients and their uses

1971 • 4,444 citations

Thomas, Springfield, Illinois

1965 • 2,935 citations

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

SEROLOGICAL EVIDENCE OF AN ASSOCIATION OF A NOVEL CHLAMYDIA, TWAR, WITH CHRONIC CORONARY HEART DISEASE AND ACUTE MYOCARDIAL INFARCTION

1988 • 1,989 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Tumor Angiogenesis

1985 • 1,038 citations

Quantitative approach to biochemical structure-activity relationships

1969 • 897 citations

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM

1977 • 786 citations

Glucose utilization of cerebral gliomas measured by [ ¹⁸ F] fluorodeoxyglucose and positron emission tomography

1982 • 760 citations

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.

1986 • 744 citations

Methotrexate: Distribution in Cerebrospinal Fluid after Intravenous, Ventricular and Lumbar Injections

1975 • 676 citations

The Spread of Tumours in the Human Body

1953 • 639 citations

Infiltration of the Leptomeninges by Systemic Cancer

1974 • 572 citations

Prediction of survival in glioma patients by means of positron emission tomography

1985 • 407 citations

Adriamycin chemotherapy—efficacy, safety, and pharmacologic basis of an intermittent single high-dosage schedule

1974 • 393 citations

Plasma and Tissue Protein Binding of Drugs in Pharmacokinetics

1976 • 375 citations

Capillary Ultrastructure and the Blood-Brain Barrier in Human Malignant Brain Tumors

1970 • 371 citations

Blood-brain barrier in physiology and medicine

1977 • 364 citations

Osmotic opening of tight junctions in cerebral endothelium

1973 • 327 citations

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

1975 • 321 citations

Clinical pharmacology of l‐β‐D‐arabinofuranosyl cytosine

1971 • 317 citations

Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.

1982 • 292 citations

Vascular structures in brain tumors

1975 • 239 citations

Intracranial tumors: response and resistance to therapeutic endeavors, 1970–1980

1982 • 235 citations

Neurotoxicity of antineoplastic drugs.

1982 • 231 citations

Parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics

1968 • 230 citations

Subarachnoid Distribution of Drugs after Lumbar Injection

1962 • 217 citations

SUBCUTANEOUS RESERVOIR AND PUMP FOR STERILE ACCESS TO VENTRICULAR CEREBROSPINAL FLUID

1963 • 216 citations

Methods for quantifying the transport of drugs across brain barrier systems

1981 • 214 citations

Delayed radiation necrosis of the brain

1977 • 207 citations

Clinical Significance of Esterases in Man

1985 • 206 citations

Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface.

1979 • 198 citations

Chemotherapy of Brain Tumors

1977 • 196 citations

Necrotizing Encephalopath Following Intraventricular Instillatio of Methotrexate

1973 • 188 citations

Toward an Understanding of Angiogenesis: Search and Discovery

1985 • 184 citations

Drug resistance in cancer.

1984 • 175 citations

Therapeutic Efficacy of Multiagent Chemotherapy with Drug Delivery Enhancement by Blood-Brain Barrier Modification in Glioblastoma

1986 • 166 citations

Permeability Characteristics of Brain Adjacent to Tumors in Rats

1975 • 165 citations

Intracranial Metastases and their Neurosurgical Treatment

1965 • 160 citations

Pharmacokinetics of methotrexate

1974 • 158 citations

Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis

1982 • 156 citations

Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 1

1976 • 154 citations

"Concentration x time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms

1978 • 149 citations

Temporary alteration of cerebrovascular permeability to plasma protein during drug-induced seizures

1972 • 143 citations

Interrelationships of some chemical, physicochemical, and biological activities of several 1-(2-haloethyl)-1-nitrosoureas.

1974 • 139 citations

Metastatic Tumors of the Central Nervous System.

1982 • 134 citations

Neurotoxicity of chemotherapeutic agents after blood‐brain barrier modification: Neuropathological studies

1983 • 129 citations

Pharmacokinetics of methotrexate

1973 • 125 citations

Developments in the diagnosis and treatment of primary CNS lymphoma: A prospective series

1986 • 123 citations

Seizures and transient cortical blindness associated with cis-platinum (II) diamminedichloride (PDD) therapy in a thirty-year-old man

1980 • 122 citations

Brain tumor chemotherapy: an evaluation of agents in current use for phase II and III trials.

1980 • 122 citations

A phase I study of intracarotid artery infusion of cis-Diamminedichloroplatinum(II) in patients with recurrent malignant intracerebral tumors.

1982 • 119 citations

Local cerebral blood flow in the conscious rat as measured with 14C-antipyrine, 14C-iodoantipyrine and 3H-nicotine.

1979 • 112 citations

Fluid Environment of the Brain

1975 • 111 citations

Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors.

1984 • 110 citations

The effect of photon irradiation on blood-brain barrier permeability to methotrexate in mice

1977 • 110 citations

Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration.

1977 • 108 citations

Positron emission tomographic measurement of blood‐to‐brain and blood‐to‐tumor transport of ⁸²Rb: The effect of dexamethasone and whole‐brain radiation therapy

1985 • 107 citations

The rationale and methodology for intra-arterial chemotherapy with BCNU as treatment for glioblastoma

1985 • 106 citations

Kinetics of entry and distribution of 5-fluorouracil in cerebrospinal fluid and brain following intravenous injection in a primate.

1973 • 106 citations

Microvascular abnormalities in virally-induced canine brain tumors

1972 • 103 citations

Positron emission tomography in the study of human tumors

1984 • 103 citations

Cerebrospinal fluid perfusion for central nervous system neoplasms

1966 • 103 citations

The Spread of Tumours in Human Body

1974 • 102 citations

Pharmacokinetics of intracarotid artery 14C-BCNU in the squirrel monkey

1978 • 101 citations

Chemotherapy of Primary Brain Tumors

1985 • 99 citations

Increased cerebrovascular permeability after repeated electroshocks

1961 • 98 citations

Chemotherapy of brain tumors: physiological and pharmacokinetic considerations.

1986 • 97 citations

Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection.

1977 • 97 citations

NEUROTOXICITY OF X-RAY CONTRAST MEDIA

1974 • 96 citations

Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 2

1976 • 95 citations

Biochemical pharmacology of the lipophilic antifolate, trimetrexate

1984 • 95 citations

The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier

1976 • 94 citations

Quantitative Measurement of Blood—Brain Barrier Permeability Using Rubidium-82 and Positron Emission Tomography

1984 • 94 citations

Fenestrated blood vessels in a metastatic renal carcinoma in the brain.

1972 • 88 citations

Vasculature of Neural Neoplasms.

1976 • 86 citations

Chemotherapy of brain metastases: Current status

1984 • 84 citations

Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system.

1987 • 84 citations

Clinical pharmacology of anticancer drugs.

1977 • 83 citations

THE DEVELOPMENT AND ULTRASTRUCTURE OF THE MICROVASCULATURE IN MALIGNANT GLIOMAS

1977 • 81 citations

A Kinetic Evaluation of Blood—Brain Barrier Permeability in Human Brain Tumors with [⁶⁸Ga]EDTA and Positron Computed Tomography

1984 • 78 citations

Intrathecal cytosine arabinoside for the treatment of meningeal metastases from malignant brain tumors and systemic tumors

1982 • 77 citations

The entry, accumulation and binding of diphenylhydantoin-2-C14 in brain Studies on adult, immature and hypercapnic cats

1963 • 74 citations

Peripheral neuropathy associated with cis-dichlorodiammineplatinum (II) treatment

1979 • 71 citations

Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice.

1970 • 70 citations

Increased penetration of horseradish peroxidase across the blood-brain barrier induced by Metrazol seizures

1975 • 66 citations

PET and NMR: New perspectives in neuroimaging and in clinical neurochemistry

1986 • 64 citations

Potential central nervous system antitumor agents. Hydantoin derivatives

1975 • 63 citations

Effectiveness of the nitrosoureas as a function of their lipid solubility in the chemotherapy of experimental rat brain tumors.

1974 • 62 citations

Brain-tumor chemotherapy

1977 • 60 citations

Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine in humans.

1974 • 60 citations

Cellular pharmacokinetics of the phenylalanine mustards

1983 • 59 citations

Potential CNS Antitumor Agents VI: Aziridinylbenzoquinones III

1979 • 58 citations

Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside

1982 • 57 citations

Circumventing the Blood-Brain Barrier with Autonomic Ganglion Transplants

1983 • 56 citations

Treatment of advanced malignant melanoma with high-dose melphalan and autologous bone marrow transplantation

1983 • 55 citations

Quantitative observations of the acute effects of X-irradiation on brain capillary permeability: Part I

1979 • 54 citations

Quantitative Aspects of Contrast Enhancement in Cranial Computed Tomography

1978 • 53 citations

Studies on the pharmacokinetics of chlorambucil and prednimustine in man.

1983 • 52 citations

Effect of X-Irradiation and Certain Other Treatments on Blood Brain Barrier Permeability

1964 • 50 citations

Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases

1987 • 49 citations

THE EXCHANGE OF MATERIAL BETWEEN CEREBROSPINAL FLUID AND BRAIN

1975 • 49 citations

Quantitative structure-activity relationships of antineoplastic drugs: nitrosoureas and triazenoimidazoles.

1972 • 49 citations

Comparison of the fed and fasting states on the absorption of melphalan in multiple myeloma

1984 • 48 citations

Effect of intravenous dose and schedule on cerebrospinal fluid pharmacokinetics of 5-fluorouracil in the monkey.

1984 • 43 citations

The protein binding of methotrexate by the serum of normal subjects

1979 • 43 citations

Blood-brain barrier integrity and host responses in experimental metastatic brain tumours

1983 • 42 citations

Barbiturate-Enhanced Detection of Brain Lesions by Carbon-14-Labeled 2-Deoxyglucose Autoradiography

1983 • 41 citations

The blood-tissue barrier of human brain tumors: correlation of scintigraphic and ultrastructural findings: concise communication.

1984 • 41 citations

Phase II and pharmacokinetic study of aziridinylbenzoquinone [2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone, diaziquone, NSC 182986] in high-grade gliomas.

1983 • 40 citations

Methotrexate analogs. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters

1984 • 39 citations

Etoposide induced blood-brain barrier disruption in rats: duration of opening and histological sequelae.

1986 • 38 citations

Intracarotid Dehydrocholate Infusion: A New Method for Prolonged Reversible Blood-Brain Barrier Disruption

1983 • 38 citations

Microvascular permeability in induced astrocytomas and peritumor neuropil of rat brain

1984 • 38 citations

Cerebral ?radiation necrosis?: Vascular and glial features

1976 • 37 citations

The role of positron emission tomography in the study of cerebral tumors.

1986 • 33 citations

Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs.

1982 • 33 citations

PCNU treatment for recurrent malignant gliomas.

1984 • 33 citations

Neurotoxicity of cis-platinum: Pathology of the central and peripheral nervous systems

1980 • 32 citations

Otosclerotic Lesions in the Inbred LP/J Mouse

1983 • 31 citations

Metastatic Tumors of the Central Nervous System

1982 • 31 citations

Inability of Dimethyl Sulfoxide and 5-Fluorouracil to Open the Blood-Brain Barrier

1983 • 31 citations

Pharmacokinetics of high dose melphalan

1983 • 28 citations

Studies on the mechanism of gastrointestinal absorption of melphalan and chlorambucil

1986 • 27 citations

Ability of a New Antitumor Agent, AZQ, to Penetrate into Cerebrospinal Fluid

1981 • 27 citations

Inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminoquinazolines and related compounds

1974 • 27 citations

Response of cultured human glioblastomas to radiation and BCNU chemotherapy

1974 • 23 citations

Gliomas induced by rous sarcoma virus in the dog--an ultrastructural study.

1971 • 23 citations

Initial Studies on the Penetration of Spirohydantoin Mustard into the Cerebrospinal Fluid of Dogs

1977 • 23 citations

Treatment of Brain Tumors

1977 • 22 citations

Preferential distribution of diphenylhydantoin in primary human brain tumors

1963 • 22 citations

Use of a Hyperbaric Solution for Administration of Intrathecal Amphotericin B

1974 • 21 citations

Revascularization of skin transplanted into the brain: Source of the graft endothelium

1984 • 19 citations

Experimental approaches to the treatment of CNS leukemia.

1979 • 18 citations

2nd Gordon Hamilton Fairley Lecture

1982 • 17 citations

Enhancement of the Anticonvulsant Action of Acetazolamide after Head X-Irradiation and Its Relation to Blood Brain Barrier Changes

1964 • 17 citations

Quantitative observations of the subacute effects of X irradiation on brain capillary permeability: Part II

1979 • 17 citations

Phase II evaluation of diaziquone (CI-904, AZQ) in the treatment of human malignant glioma

1985 • 17 citations

Axial transverse computerized tomography in 73 glioblastomas

1978 • 16 citations

Phase II study of aziridinylbenzoquinone (AZQ) in patients with central nervous system malignancies: a Southwest Oncology Group study

1985 • 15 citations

Pharmacologic studies on the dibutyl and ?-monobutyl esters of methotrexate in the rhesus monkey

1982 • 14 citations

Phase 11 study of aziridinylbenzoquinone (AZQ: NSC-182986) in the treatment of malignant gliomas recurrent after radiation

1985 • 14 citations

Combined cyclotron fast-neutron and BCNU therapy in a rat brain-tumor model

1981 • 13 citations

High-Dose Alkylating Agent Therapy: A Review of Clinical Experiences

1984 • 13 citations

CHEMOTHERAPY OF RECURRENT BRAIN TUMORS

1981 • 13 citations

Enhanced cerebrovascular permeability by Metrazol: significance for brain metastases

1983 • 11 citations

Muscle Grafts as Entries for Blood-borne Proteins into the Extracellular Space of the Brain

1986 • 11 citations

Aryl-2-halogenoalkylamines—XX

1962 • 11 citations

Hyberbaric cisternography: experience in humans.

1973 • 11 citations

Razoxane penetration into the cerebrospinal fluid of rats

1982 • 10 citations

Phase II trial of prednimustine in glioblastoma multiforme.

1984 • 9 citations

Quantitative Aspects of Osmotic Opening of the Blood-Brain Barrier

1980 • 8 citations

Physiological and Electrophysiological Consequences of Etoposide-induced Blood-Brain Barrier Disruption

1986 • 7 citations

Short communication: Metrazol enhances brain penetration and therapeutic efficacy of some anticancer agents: implications for brain metastases

1984 • 6 citations

Intracerebral penetration of intraventricularly administered methotrexate: A quantitative autoradiographic study

1985 • 2 citations