Chemotherapy of brain tumors: physiological and pharmacokinetic considerations.

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

Pathology of Tumors of the Nervous System.

1964 • 1,494 citations

The Permeability of Capillaries in Various Organs as Determined by Use of the ‘Indicator Diffusion’ Method

1963 • 1,138 citations

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

The Permeability of Natural Membranes

1944 • 752 citations

Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles

1959 • 717 citations

Capillary Ultrastructure and the Blood-Brain Barrier in Human Malignant Brain Tumors

1970 • 371 citations

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

1975 • 321 citations

Vascular structures in brain tumors

1975 • 239 citations

Methods for quantifying the transport of drugs across brain barrier systems

1981 • 214 citations

Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface.

1979 • 198 citations

Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography: Analytical techniques and preliminary results

1982 • 185 citations

Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier.

1982 • 184 citations

Nonlinear pharmacokinetic models for 5-fluorouracil in man: Intravenous and intraperitoneal routes

1980 • 181 citations

Permeability Characteristics of Brain Adjacent to Tumors in Rats

1975 • 165 citations

Mechanisms of Drug Absorption and Excretion Passage of Drugs in and out of the Central Nervous System

1962 • 147 citations

Application of Quantitative Autoradiographic Measurements in Experimental Brain Tumor Models

1981 • 138 citations

Neurotoxicity of chemotherapeutic agents after blood‐brain barrier modification: Neuropathological studies

1983 • 129 citations

THE BIOGENESIS OF MITOCHONDRIA

1968 • 127 citations

Heuristic modeling of drug delivery to malignant brain tumors

1980 • 112 citations

Microvascular abnormalities in virally-induced canine brain tumors

1972 • 103 citations

The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier

1976 • 94 citations

Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate.

1982 • 87 citations

Vasculature of Neural Neoplasms.

1976 • 86 citations

Regional Blood Flow and Blood-to-Tissue Transport in Five Brain Tumor Models

2015 • 78 citations

Pharmacokinetics of BCNU in man: a preliminary study of 20 patients.

1978 • 68 citations

Regional measurements of blood flow in experimental RG-2 rat gliomas.

1983 • 66 citations

Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas.

1983 • 58 citations

Treatment of patients with recurrent primary brain tumors with AZQ

1984 • 56 citations

The effect of graded hypertonic intracarotid infusions on drug delivery to experimental RG‐2 gliomas

1984 • 54 citations

Quantitative Aspects of Contrast Enhancement in Cranial Computed Tomography

1978 • 53 citations

Regional blood‐to‐tissue transport in ethylnitrosourea‐induced brain tumors

1983 • 53 citations

Regional blood flow in RT-9 brain tumors

1983 • 53 citations

Regional blood flow in ethylnitrosourea‐induced brain tumors

1983 • 45 citations

Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors: implications for chemotherapy.

1984 • 44 citations

Regional blood-to-tissue transport in RT-9 brain tumors

1983 • 44 citations

Sodium and potassium content of normal and neoplastic rodent astrocytes in cell culture.

1971 • 43 citations

Regional blood flow in avian sarcoma virus (ASV)‐induced brain tumors

1983 • 33 citations

Local blood-to-tissue transport in Walker 256 metastatic brain tumors

1984 • 32 citations

Brain Tumor Microvasculature

1980 • 32 citations

Diagnosis and Localization of Brain Tumors: A Clinical and Experimental Study Employing Fluorescent and Radioactive Tracer Methods

1954 • 31 citations

Regional blood‐to‐tissue transport in avian sarcoma virus (ASV)‐induced brain tumors

1983 • 30 citations

Local blood flow in Walker 256 metastatic brain tumors

1984 • 23 citations

Ultrastructural basis for different pertechnetate uptake patterns by various human brain tumours.

1979 • 21 citations

Pharmacokinetics and Metastatic Brain Tumor Chemotherapy

1980 • 19 citations

Axial transverse computerized tomography in 73 glioblastomas

1978 • 16 citations

Application of monoclonal antibodies to tumor diagnosis and therapy.

1983 • 14 citations

Determination of regional blood-tissue transfer constants and initial (plasma) volume in brain and brain tumors using 68Ga-EDTA and dynamic positron emission tomography

1984 • 3 citations

Simultaneous estimations of blood brain barrier (BBB) permeability and local cerebral blood volume (CBV) in human brain tumors with positron tomography and Ga-68 EDTA

1984 • 3 citations