Chemotherapy of brain metastases: Current status

THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man.

1979 • 1,184 citations

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM

1977 • 786 citations

Glucose utilization of cerebral gliomas measured by [ ¹⁸ F] fluorodeoxyglucose and positron emission tomography

1982 • 760 citations

Methotrexate: Distribution in Cerebrospinal Fluid after Intravenous, Ventricular and Lumbar Injections

1975 • 676 citations

Intracranial metastases from systemic cancer.

1978 • 621 citations

Infiltration of the Leptomeninges by Systemic Cancer

1974 • 572 citations

The pharmacokinetics of Norpace.

1975 • 567 citations

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

1970 • 546 citations

Clinical and pharmacological studies with cis-diamminedichloroplatinum (II).

1973 • 430 citations

Control of Cerebral Circulation in Health and Disease

1974 • 395 citations

Lipid Solubility and Drug Penetration of the Blood Brain Barrier

1974 • 372 citations

Capillary Ultrastructure and the Blood-Brain Barrier in Human Malignant Brain Tumors

1970 • 371 citations

Amine mechanisms in the cerebral circulation.

1976 • 343 citations

Osmotic opening of tight junctions in cerebral endothelium

1973 • 327 citations

The Vascularization of Tumors

1976 • 318 citations

Clinical pharmacology of l‐β‐D‐arabinofuranosyl cytosine

1971 • 317 citations

Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.

1982 • 292 citations

Metastatic carcinoma in the central nervous system and dorsal root ganglia.A prospective autopsy study

1963 • 287 citations

Quantitative aspects of reversible osmotic opening of the blood-brain barrier

1980 • 276 citations

Management of central nervous system metastases

2020 • 272 citations

Neurotoxicity of antineoplastic drugs.

1982 • 231 citations

The effect of acute arterial hypertension on the blood-brain barrier to protein tracers

1970 • 224 citations

Influence of Dimethylsulfoxide (DMSO)

1964 • 221 citations

Subarachnoid Distribution of Drugs after Lumbar Injection

1962 • 217 citations

SUBCUTANEOUS RESERVOIR AND PUMP FOR STERILE ACCESS TO VENTRICULAR CEREBROSPINAL FLUID

1963 • 216 citations

Pharmacokinetics and metabolism of adriamycin in man

1973 • 213 citations

Filtration and reflection coefficients of the rabbit blood-brain barrier

1966 • 200 citations

Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface.

1979 • 198 citations

Chemotherapy of Brain Tumors

1977 • 196 citations

Half body radiotherapy

1976 • 184 citations

The Blood Brain Barrier

1971 • 183 citations

Microwave alteration of the blood-brain barrier system of rats

1977 • 176 citations

Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis

1981 • 167 citations

Permeability Characteristics of Brain Adjacent to Tumors in Rats

1975 • 165 citations

Acute lymphoblastic leukemia in infants less than one year of age: a cumulative experience of the Children's Cancer Study Group.

1985 • 164 citations

Treatment of meningeal neoplasms.

1977 • 160 citations

Intracranial Metastases and their Neurosurgical Treatment

1965 • 160 citations

Problems of delivery of drugs to the brain

1982 • 158 citations

Cell kinetics of human gliomas

1972 • 158 citations

Pharmacokinetics of methotrexate

1974 • 158 citations

Clinical Pharmacokinetics of Hydralazine

1982 • 155 citations

Metastatic Brain Tumors: Results of Surgical and Nonsurgical Treatment

1964 • 155 citations

Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 1

1976 • 154 citations

"Concentration x time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms

1978 • 149 citations

Spinal descent of cerebrospinal fluid in man

1976 • 147 citations

Morphologic Effect of Dimethyl Sulfoxide on the Blood-Brain Barrier

1982 • 146 citations

Kinetics of movement of iodide, sucrose, inulin and radio‐iodinated serum albumin in the central nervous system and cerebrospinal fluid of the rat

1963 • 141 citations

Interrelationships of some chemical, physicochemical, and biological activities of several 1-(2-haloethyl)-1-nitrosoureas.

1974 • 139 citations

Application of Quantitative Autoradiographic Measurements in Experimental Brain Tumor Models

1981 • 138 citations

Rapid-course radiation therapy of cerebral metastases: Results and complications

1974 • 137 citations

Central nervous system involvement by ovarian carcinoma.A complication of prolonged survival with metastatic disease

1978 • 134 citations

Pacific Grove, California

1906 • 130 citations

Neurotoxicity of chemotherapeutic agents after blood‐brain barrier modification: Neuropathological studies

1983 • 129 citations

Pharmacokinetics and metabolism of vinblastine in humans.

1977 • 126 citations

Quantitative studies of the passage of different substances out of the cerebro‐spinal fluid

1962 • 123 citations

Brain tumor chemotherapy: an evaluation of agents in current use for phase II and III trials.

1980 • 122 citations

Pharmacokinetics of VP16-213 given by different administration methods

1982 • 121 citations

Surgery for metastatic intracranial neoplasm

1972 • 119 citations

Osmotic Opening of the Blood-Brain Barrier in the Monkey without Associated Neurological Deficits

1973 • 116 citations

Studies of the enzymatic deamination of ara-cytidine—V

1968 • 113 citations

Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors.

1984 • 110 citations

The effect of photon irradiation on blood-brain barrier permeability to methotrexate in mice

1977 • 110 citations

Single-Agent Chemotherapy of Brain Tumors

1976 • 110 citations

Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization

1979 • 109 citations

Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration.

1977 • 108 citations

"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.

1977 • 107 citations

Kinetics of entry and distribution of 5-fluorouracil in cerebrospinal fluid and brain following intravenous injection in a primate.

1973 • 106 citations

The physiological disposition of the carcinostatic 1,3‐bis(2‐chloroethyU‐l‐nitrosourea (BCNU) in man and animals

1967 • 106 citations

The pharmacokinetics of [₃H]‐vincristine in man

1977 • 105 citations

Monitoring of Methotrexate Delivery in Patients with Malignant Brain Tumors After Osmotic Blood-Brain Barrier Disruption

1981 • 104 citations

Microvascular abnormalities in virally-induced canine brain tumors

1972 • 103 citations

Cerebrospinal fluid perfusion for central nervous system neoplasms

1966 • 103 citations

Remission induction of meningeal leukemia with high-dose intravenous methotrexate.

1985 • 101 citations

Successful Treatment of Primary Central Nervous System Lymphomas with Chemotherapy after Osmotic Blood-Brain Barrier Opening

1983 • 99 citations

Increased cerebrovascular permeability after repeated electroshocks

1961 • 98 citations

Pharmacokinetics of vindesine and vincristine in humans.

1977 • 98 citations

Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection.

1977 • 97 citations

Pharmacology and toxicity of intracarotid adriamycin administration following osmotic blood-brain barrier modification.

1981 • 96 citations

NEUROTOXICITY OF X-RAY CONTRAST MEDIA

1974 • 96 citations

Diagnosis and treatment of metastases to the brain.

1974 • 92 citations

A REVIEW OF EXPERIENCE WITH IRRADIATION OF BRAIN METASTASIS

1971 • 91 citations

The effects of salicylate and probenecid on the cerebrospinal fluid transport of penicillin, aminosalicyclic acid and iodide.

1974 • 88 citations

The absorption, distribution, excretion, and biotransformation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in animals.

1970 • 87 citations

Increased incidence of cerebral metastases in sarcoma patients with prolonged survival from chemotherapy.Report of cases of leiomysarcoma and chondrosarcoma

1975 • 86 citations

Vasculature of Neural Neoplasms.

1976 • 86 citations

The preclinical new drug research program of the National Cancer Institute.

1984 • 85 citations

Phase II study—intra-arterial bcnu therapy for metastatic brain tumors

1981 • 82 citations

Computed Tomography in Astrocytomas

1978 • 82 citations

THE DEVELOPMENT AND ULTRASTRUCTURE OF THE MICROVASCULATURE IN MALIGNANT GLIOMAS

1977 • 81 citations

The Effect of Hypercapnia on Brain Permeability to Protein

1966 • 80 citations

Pathology of leukemia in the brain and meninges: postmortem studies of patients with acute leukemia and of mice given inoculations of L1210 leukemia.

1965 • 80 citations

DECREASED RATE OF GLUCOSE UTILIZATION BY RAT BRAIN IN VIVO AFTER EXPOSURE TO ATMOSPHERES CONTAINING HIGH CONCENTRATIONS OF CO₂

1975 • 78 citations

Brain metastases in breast cancer patients receiving adjuvant chemotherapy

1982 • 74 citations

The entry, accumulation and binding of diphenylhydantoin-2-C14 in brain Studies on adult, immature and hypercapnic cats

1963 • 74 citations

Delivery of a Quaternary Pyridinium Salt Across the Blood-Brain Barrier by Its Dihydropyridine Derivative

1975 • 71 citations

Skin penetrating property of drugs dissolved in dimethylsulfoxide (DMSO) and other vehicles

1964 • 70 citations

Pharmacokinetics of BCNU in man: a preliminary study of 20 patients.

1978 • 68 citations

Increased penetration of horseradish peroxidase across the blood-brain barrier induced by Metrazol seizures

1975 • 66 citations

Pharmacokinetics of vincristine in the cerebrospinal fluid of humans.

1981 • 66 citations

Physiologic disposition of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU) in man

1973 • 64 citations

Phase II study of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) in the treatment of brain tumors.

1972 • 63 citations

Potential central nervous system antitumor agents. Hydantoin derivatives

1975 • 63 citations

Effectiveness of the nitrosoureas as a function of their lipid solubility in the chemotherapy of experimental rat brain tumors.

1974 • 62 citations

SURVIVAL AFTER SURGICAL EXCISION OF SINGLE METASTATIC BRAIN TUMORS

1971 • 62 citations

Osmotic blood-brain barrier disruption in the posterior fossa of the dog

1981 • 58 citations

Current status of intrathecal chemotherapy for human meningeal neoplasms.

1977 • 55 citations

Quantitative observations of the acute effects of X-irradiation on brain capillary permeability: Part I

1979 • 54 citations

Experimental vincristine myopathy--a histochemical, ultrastructural and biochemical study.

1971 • 53 citations

Preliminary Clinical Assessment of I.C.R.F. 159 in Acute Leukaemia and Lymphosarcoma

1969 • 53 citations

Effect of X-Irradiation and Certain Other Treatments on Blood Brain Barrier Permeability

1964 • 50 citations

THE EXCHANGE OF MATERIAL BETWEEN CEREBROSPINAL FLUID AND BRAIN

1975 • 49 citations

Quantitative structure-activity relationships of antineoplastic drugs: nitrosoureas and triazenoimidazoles.

1972 • 49 citations

Distribution and metabolism of vincristine in mice, rats, dogs, and monkeys.

1977 • 46 citations

Two Morphologically Distinct Blood-Brain Barriers Preventing Entry of Cytochrome c into Cerebrospinal Fluid

1973 • 45 citations

Chemotherapeutic Agent Permeability to Normal Brain and Delivery to Avian Sarcoma Virus-induced Brain Tumors in the Rodent: Observations on Problems of Drug Delivery

1984 • 45 citations

Absence of microwave effect on blood-brain barrier permeability to [14C]sucrose in the conscious rat

1982 • 44 citations

Enhancement of CNS penetration of methotrexate by hyperosmolar intracarotid mannitol or carcinomatous meningitis

1979 • 44 citations

The protein binding of methotrexate by the serum of normal subjects

1979 • 43 citations

Possible enhancement of vincristine neuropathy by VP-16

1982 • 42 citations

Osmotic opening of the blood-brain barrier to methotrexate in the rat.

1979 • 42 citations

Remission Maintenance Therapy for Meningeal Leukemia: Intrathecal Methotrexate vs. Intravenous bis-Nitrosourea

1971 • 41 citations

Mass spectrometric study of the distribution of cyclophosphamide in humans

1973 • 38 citations

Experimental intracerebral movement of electron microscopic tracers of various molecular sizes

1975 • 36 citations

Dialkyl esters of methotrexate and 3',5'-dichloromethotrexate: synthesis and interaction with aldehyde oxidase and dihydrofolate reductase.

1973 • 35 citations

Clinical trials of misonidazole in the United States.

1981 • 34 citations

Localized changes in blood-brain barrier permeability following the administration of antineoplastic drugs.

1978 • 34 citations

Phase I and pharmacological study of acivicin by 24-hour continuous infusion.

1982 • 34 citations

Cyclophosphamide plasma and cerebrospinal fluid kinetics with and without dimethyl sulfoxide

1982 • 33 citations

Immunotherapy of gliomas: a review.

1976 • 33 citations

Elimination of a Quaternary Pyridinium Salt Delivered as Its Dihydropyridine Derivative from Brain of Mice

1978 • 32 citations

Inability of Dimethyl Sulfoxide and 5-Fluorouracil to Open the Blood-Brain Barrier

1983 • 31 citations

Prognostic factors in patients with non-small cell bronchogenic carcinoma and brain metastases

1982 • 30 citations

Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice.

1983 • 29 citations

Transport of 1-Aminocyclopentanecarboxylic Acid from Feline Cerebrospinal Fluid

1968 • 28 citations

Regional cerebral blood flow in various types of brain tumor

1982 • 28 citations

Ability of a New Antitumor Agent, AZQ, to Penetrate into Cerebrospinal Fluid

1981 • 27 citations

Lipophilic drugs and lipoproteins: partitioning effects on chloroethylnitrosourea reaction rates in serum.

1980 • 27 citations

Aggressive multimodality therapy based on a multicompartmental model of glioblastoma.

1982 • 26 citations

Diaziquone, 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone, plasma and cerebrospinal fluid kinetics

1982 • 26 citations

Chemotherapy of experimental metastatic brain tumors in female Wistar rats.

1979 • 25 citations

Initial Studies on the Penetration of Spirohydantoin Mustard into the Cerebrospinal Fluid of Dogs

1977 • 23 citations

Intracerebral Growth of a Human Glioma Tumor Line in Athymic Mice and Treatment with Procarbazine, 1,3-Bis(2-chloroethyl)-l-nitrosourea, Aziridinylbenzoquinone, and cis-Platinum

1983 • 23 citations

Extensive disease small cell carcinoma of the lung. Trial of non-cross resistant chemotherapy and consolidation radiotherapy

1982 • 22 citations

Preferential distribution of diphenylhydantoin in primary human brain tumors

1963 • 22 citations

Treatment of Brain Tumors

1977 • 22 citations

Correlations between experimental chemotherapy in the murine glioma and effectiveness of clinical therapy regimens

1978 • 21 citations

Combination carmustine (BCNU) and dianhydrogalactitol in the treatment of primary brain tumors recurring after irradiation.

1982 • 19 citations

Distribution and excretion studies of procarbazine in animals and man.

1967 • 18 citations

Passage of drugs into and out of the central nervous system.

1965 • 18 citations

Phase I study of aziridinylbenzoquinone (AZQ, NSC 182986) in children with cancer.

1984 • 18 citations

Comparative effects of citrovorum factor and carboxypeptidase G1 on cerebrospinal fluid-methotrexate pharmacokinetics.

1978 • 18 citations

Experimental approaches to the treatment of CNS leukemia.

1979 • 18 citations

Treatment of Brain Metastases by Surgical Extirpation

1980 • 18 citations

Anguidine: a broad phase II study of the Southeastern Cancer Study Group.

1984 • 18 citations

High Dose BCNU Followed by Autologous Bone Marrow Infusion in Glioblastoma Multiforme

1981 • 17 citations

Plasma half-life of cytosine arabinoside in patients with leukaemia—the effect of uridine

1975 • 14 citations

Use of Metrizamide Computerized Tomographic Cisternography in the Evaluation of Patients with Malignant Glioma for Immunotherapy

1979 • 14 citations

Clinical Toxicity of Combined Modality Treatment with Nitrosourea Derivatives for Central Nervous System Tumors

1982 • 13 citations

Preliminary Report on Antitumorigenic Activity of CIS-Dichlorodiamine Platinum in Metastatic Brain Tumors

1981 • 13 citations

Phase II trial of PCNU in children with recurrent brain tumors and Hodgkin's disease.

1984 • 13 citations

A phase I trial of aziridinylbenzoquinone (NSC 182986) in patients with previously treated acute leukemia

1982 • 12 citations

Effect of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors.

1979 • 12 citations

Tracer-Studien mit radioaktiv markiertem Cyclophosphamid bei Hirntumoren

1965 • 12 citations

Preliminary communication — Treatment of primary brain tumors recurrent after irradiation with aziridinylbenzoquinone (AZQ; NSC-182986)

1983 • 12 citations

Changes in drug delivery (by blood-brain barrier dysfunction) on arachnoid leukemia: implication for CNS leukemic dissemination

1983 • 12 citations

Enhanced cerebrovascular permeability by Metrazol: significance for brain metastases

1983 • 11 citations

Chemotherapy of Metastatic Central Nervous System Carcinoma

1980 • 11 citations

Comparative disposition of phosphoramide mustard and other cyclophosphamide metabolites in the mouse using the Salmonella/mutagenesis assay.

1978 • 10 citations

Aziridinylbenzoquinone (AZQ) treatment of central nervous system leukemia.

1982 • 10 citations

Razoxane penetration into the cerebrospinal fluid of rats

1982 • 10 citations

Phase II trial of aziridinylbenzoquinone (AZQ) in patients with refractory small cell carcinoma of the lung

1983 • 8 citations

Quantitative Aspects of Osmotic Opening of the Blood-Brain Barrier

1980 • 8 citations

Die Wirkung kombinierter Chemotherapie (Adriamycin/VM 26/CCNU) bei hirneigenen Tumoren des Erwachsenenalters und im Tierexperiment

1982 • 7 citations

Products of Cultured Neuroglial Cells. III. Release of an 85,000 Molecular Weight Glycoprotein by C6 Glioma Cells In Vitro

1982 • 7 citations

The Hahnemann Experience

1980 • 7 citations

A phase II study of aziridinylbenzoquinone (AZQ) in advanced large bowel carcinoma

1982 • 6 citations

The Princess Margaret and Ontario Cancer Foundation Experience

1980 • 6 citations

Short communication: Metrazol enhances brain penetration and therapeutic efficacy of some anticancer agents: implications for brain metastases

1984 • 6 citations

Combined Chemotherapy and Irradiation in the Treatment of Brain Metastases from Lung Cancer

1980 • 6 citations

COMPARISON OF METHODS FOR DETERMINING BLOOD-BRAIN BARRIER PERMEABILITY

1975 • 5 citations

Phase II trial of diaziquone (AZQ) in advanced malignant melanoma

1983 • 4 citations

Aziridinylbenzoquinone (AZQ) in advanced breast cancer: a Cancer and Leukemia group B phase II trial.

1982 • 4 citations

The interaction of the bisquaternary ammonium compound hexafluorenium with the histaminic receptor in the guinea-pig ileum

1971 • 4 citations

Seashore Patterns: Life between Tidemarks on Rocky Shores . T. A. Stephenson and Anne Stephenson. Freeman, San Francisco, 1972. xiv, 426 pp., illus. Cloth, $15; paper, $6.95.

1973 • 3 citations

Deleted Work

1955 • 0 citations