Biochemical pharmacology of the lipophilic antifolate, trimetrexate

BMD : biomedical computer programs

1965 • 2,753 citations

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

1969 • 779 citations

Culture of Normal Human Leukocytes

1967 • 774 citations

A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors

1972 • 524 citations

Application of Stepwise Regression to Non-Linear Estimation

1968 • 217 citations

The clinical pharmacology of methotrexate

1983 • 213 citations

Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats.

1980 • 104 citations

Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.

1983 • 100 citations

Intrinsic Resistance to Methotrexate of Cultured Mammalian Cells in Relation to the Inhibition Kinetics of Their Dihydrofolate Reductases

1976 • 91 citations

Toward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture.

1979 • 90 citations

Factors determining cell sensitivity to methotrexate: Studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines

1974 • 84 citations

Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines

1983 • 81 citations

Combination chemotherapy: The interaction of methotrexate and 5-fluorouracil

1973 • 74 citations

6 Recent Progress in the Medicinal Chemistry of 2,4-Diaminopyrimidines

1982 • 73 citations

Application of Stepwise Regression to Non-Linear Estimation

1968 • 66 citations

Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.

1982 • 65 citations

Purification and characterization of dihydrofolate reductase from methotrexate-resistant human lymphoblastoid cells

1983 • 53 citations

Inhibition of histamine-metabolizing enzymes and elevation of histamine levels in tissues by lipid-soluble anticancer folate antagonists.

1980 • 45 citations

Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs.

1982 • 33 citations

Enzyme pattern-directed chemotherapy

1979 • 31 citations

DDMP (2,4-diamino-5-(3′,4′-dichlorophenyl)-methylpyrimidine)

1980 • 28 citations

Purine modulation of methotrexate cytotoxicity in mammalian cell lines.

1982 • 28 citations

Inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminoquinazolines and related compounds

1974 • 27 citations

Biochemical Mechanisms of Resistance to Antimetabolites

2015 • 17 citations

Enzymatic assays for 2, 4-diamino-5-methyl-6-[(3, 4, 5-trimethoxyanilino)methyl]quinazoline, a promising new “nonclassical” antifolate

1981 • 12 citations

Potent inhibitory activity of trimethoxyquine (tmq), "nonclassical" 2,4, diaminoquinazoline, on mammalian dna synthesis. Abstr.

1977 • 12 citations

Biochemical and biological characterization of two new antifols, nsc 127755 and tmq, in comparison with methotrexate. Abstr.

1980 • 10 citations

Further pharmacological studies of 2,4-diamino-5-methyl-6-[(3,4,5- -trimethoxyanilino)methyl]quinazoline (nsc 249008; tmq). Abstr.

1981 • 10 citations