Cellular pharmacokinetics of the phenylalanine mustards

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

Distinct Mediating Systems for the Transport of Neutral Amino Acids by the Ehrlich Cell

1963 • 839 citations

Cancer. A Comprehensive Treatise

1975 • 742 citations

Studies on plant amylases

1932 • 727 citations

The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides

1946 • 717 citations

Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

1978 • 707 citations

Effects of Some Chemical Mutagens and Carcinogens on Nucleic Acids

1966 • 370 citations

The Collected Papers of Paul Ehrlich

2013 • 363 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Biological Alkylating Agents

1962 • 355 citations

Counting actively metabolizing tissue cultured cells

1957 • 334 citations

The incorporation of 3H-cytosine arabinoside and its effect on murine leukemic cells (L5178Y)

1968 • 296 citations

Comparison of in vitro methods to determine drug-induced cell lethality.

1976 • 278 citations

Genetic and Allied Effects of Alkylating Agents

1966 • 216 citations

DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia to cis-diamminedichloroplatinum(II) and L-phenylalanine mustard.

1981 • 213 citations

SYNTHETIC AMINO ACIDS AND THE NATURE OF <scp>l</scp>‐DOPA TRANSPORT AT THE BLOOD‐BRAIN BARRIER

1975 • 210 citations

Reduction in glutathione content of L-PAM resistant L1210 cells confers drug sensitivity

1982 • 205 citations

A Bicyclic Amino Acid to Improve Discriminations among Transport Systems

1969 • 204 citations

A Method for Counting the Viable Cells in Normal and in Malignant Cell Suspensions

1936 • 201 citations

Cyto-active amino-acid and peptide derivatives. Part I. Substituted phenylalanines

1954 • 163 citations

Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links.

1978 • 154 citations

Dechlorination of l-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content

1983 • 154 citations

A comparison of methods for estimating the viable count of a suspension of tumour cells

1956 • 138 citations

Active carrier-mediated transport of melphalan by two separate amino acid transport systems in LPC-1 plasmacytoma cells in vitro.

1979 • 132 citations

Isolation, Crystallization, and Properties of Achromobacteraceae Glutaminase-Asparaginase with Antitumor Activity

1972 • 123 citations

Kinetics of intravenous melphalan

1979 • 113 citations

Oral melphalan kinetics

1979 • 110 citations

Transport of melphalan by sensitive and resistant L1210 cells.

1980 • 109 citations

Nature of the Cosubstrate Action of Na+ and Neutral Amino Acids in a Transport System

1971 • 106 citations

Cytotoxicity as an indicator for transport mechanism. Evidence that melphalan is transported by two leucine-preferring carrier systems in the L1210 murine leukemia cell

1979 • 100 citations

Pharmaco-kinetics of melphalan following oral or intravenous administration in patients with malignant disease

1978 • 99 citations

Hypoxic cell sensitizers for radiotherapy

1978 • 94 citations

Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole.

1980 • 93 citations

Amino acid-conferred protection against melphalan—Characterization of melphalan transport and correlation of uptake with cytotoxicity in cultured L1210 murine leukemia cells

1978 • 87 citations

STUDIES ON THE ANTI-TUMOUR ACTIVITY OF p-DI-(2-CHLOROETHYL) AMINOPHENYLALANINE (SARCOLYSINE)

1955 • 87 citations

Pharmacokinetics of oral and intravenous melphalan during routine treatment of multiple myeloma

1982 • 85 citations

2-Aminonorbornane-2-carboxylic acid. Preparation, properties, and identification of the four isomers

1972 • 82 citations

Mechanism of melphalan resistance developed in vitro in human melanoma cells.

1981 • 79 citations

Evidence for active transport of melphalan by two amino acid carriers in L5178Y lymphoblasts in vitro.

1979 • 79 citations

Comparison of nitrogen‐mustard‐sensitive and ‐resistant yoshida sarcomas

1966 • 77 citations

Tumour sulphydryl levels and sensitivity to the nitrogen mustard merophan

1963 • 77 citations

L-phenylalanine mustard (L-PAM): the first 25 years.

1980 • 58 citations

Membrane transport, sulfhydryl levels and DNA cross-linking in Chinese hamster ovary cell mutants sensitive and resistant to melphalan

1983 • 54 citations

Membrane transport of alkylating agents

1980 • 48 citations

Chemotherapy of advanced ovarian carcinoma: A prospective randomized comparison of phenylalanine mustard and high dose cyclophosphamide

1974 • 47 citations

Melphalan versus adriamycin in the treatment of advanced carcinoma of the ovary.

1975 • 44 citations

Evidence for carrier-mediated transport of melphalan by L5178Y lymphoblasts in vitro.

1977 • 42 citations

COMPARATIVE PHARMACOLOGY OF ALKYLATING AGENTS. I.

1965 • 39 citations

Selection and characterization of Chinese hamster ovary cell mutants resistant to melphalan (L-phenylalanine mustard).

1981 • 37 citations

PROPERTIES OF L5178Y LYMPHOBLASTS HIGHLY RESISTANT TO NITROGEN MUSTARD*

1969 • 34 citations

The role of drug transport in resistance to nitrogen mustard and other alkylating agents in L518Y lymphoblsts.

1975 • 32 citations

Mechanism of natural and acquired resistance to methyl-bis-(beta-chlorethyl)-amine N-oxide in ascites tumors.

1961 • 29 citations

L-phenylalanine mustard (melphalan) uptake and cross-linking in the RPMI 6410 human lymphoblastoid cell line.

1980 • 29 citations

Cytotoxicity as an indicator for transport mechanism: evidence that murine bone marrow progenitor cells lack a high-affinity leucine carrier that transports melphalan in murine L1210 leukemia cells

1980 • 28 citations

A comparison of melphalan transport in human breast cancer cells and lymphocytes in vitro

1980 • 26 citations

Potential Anticancer Agents.¹ XVII. Alkylating Agents to Phenylalanine Mustard. I.

1959 • 26 citations

Mechanism of Action of Nitrosoureas

1975 • 26 citations

Mechanism of Action of 2-Chloroethylamine Derivatives, Sulfur Mustards, Epoxides, and Aziridines

1975 • 25 citations

Biological alkylating agents : fundamental chemistry and the design of compounds for selective toxicity

1962 • 24 citations

Interaction of L- and D-3-amino-1-chloro-2-pentanone with gamma-glutamylcysteine synthetase.

1980 • 22 citations

Pharmacokinetics of the absorption, distribution, and elimination of melphalan in the dog.

1977 • 22 citations

Biological alkylating agents: Fundamental chemistry and the design of compounds for selective toxicity

1963 • 20 citations

Amino acid-conferred resistance to melphalan. I. Structure-activity relationship in cultured murine L1210 leukemia cells.

1976 • 19 citations

Molecular Biology of Alkylation: An Overview

1975 • 19 citations

The effect of alkylating agents and other drugs on the accumulation of melphalan by murine L1210 leukaemia cells in vitro

1982 • 18 citations

The effect of nitrogen mustards on the incorporation of amino acids into protein by Staphylococcus aureus

1957 • 18 citations

Mechanism of efflux of melphalan from L5178Y lymphoblasts in vitro.

1982 • 18 citations

Resistance patterns of Walker carcinosarcoma 256 and other rodent tumors to cyclophosphamide and L-phenylalanine mustard.

1980 • 17 citations

Melphalan‐induced chromosome damage in sensitive and resistant human melanoma cell lines

1978 • 17 citations

Concentrative uptake of melphalan, a cancer chemotherapeutic agent which is transported by the leucine-preferring carrier system

1979 • 17 citations

Amino acid conferred protection against melphalan interference with melphalan therapy by L-leucine, a competitive substrate for transport

1979 • 16 citations

Tumor Cytotoxicity

1966 • 14 citations

Studies on the mechanism of resistance to alkylating agents of three ascites tumours in the rat

1970 • 12 citations

Uptake of melphalan by human ovarian carcinoma cells and its relationship to the amino acid content of ascitic fluid.

1981 • 11 citations

Carrier mechanism and specificity accounting for the increase in intracellular melphalan by the basic amino acids.

1981 • 11 citations

Mechanism of natural and acquired resistance to methyl-bis(2-chloroethyl)amine N-oxide in ascites tumors. I. Permeability of tumor cells to alkylating agents.

1962 • 11 citations

Substrate specificity of a high-affinity, monovalent cation-dependent amino acid carrier

1979 • 10 citations

Enhancement of melphalan therapy with glutaminase:asparaginase.

1978 • 10 citations

The Synthesis of m-[Di-(2-chloroethyl)-amino]-DL-phenylalanine

1959 • 9 citations

Potentiation of antitumor drug action by centrophenoxine: specificity.

1977 • 9 citations

Amino acid conferred protection against melphalan: interference with leucine protection of melphalan cytotoxicity by the basic amino acids in cultured murine L1210 leukemia cells.

1978 • 8 citations

Potentiation of the cytotoxic action of melphalan and "activated" cyclophosphamide against cultured tumor cells by centrophenoxine.

1977 • 8 citations

Amino acids affecting melphalan transport and cytotoxicity in cultured l1210 cells. Abstr.

1977 • 7 citations

Cytotoxicities of the l and d isomers of phenylalanine mustard in L1210 cells

1979 • 6 citations

Comparative antitumor effects of peptichemio and other alkylating agents.

1977 • 5 citations

Mechanism of Action of Methanesulfonates

1975 • 4 citations

Cytotoxic activity of alkylating agents in the presence of centrophenoxine and its hydrolysis products.

1977 • 4 citations

Amino acid conferred protection against melphalan: comparison of amino acids which reduce melphalan toxicity to murine bone marrow precursor cells (CFU-C) and murine L1210 leukemia cells.

1979 • 4 citations

Cytotoxic activity of mechlorethamine and melphalan against cultured tumor cells: potentiation by caffeine.

1978 • 3 citations

Effect of L-α-amino-γ-guanidinobutyric acid on melphalan therapy of the L1210 murine leukemia

1979 • 3 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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