Toward an Understanding of Angiogenesis: Search and Discovery

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS

1971 • 1,643 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Anti-Angiogenesis

1972 • 1,167 citations

Polymers for the sustained release of proteins and other macromolecules

1976 • 1,127 citations

Angiogenesis in vitro

1980 • 1,041 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION

1972 • 898 citations

Activated macrophages induce vascular proliferation

1977 • 818 citations

SELF-REGULATION OF GROWTH IN THREE DIMENSIONS

1973 • 811 citations

Long-term culture of capillary endothelial cells.

1979 • 780 citations

Important Advances in Oncology

1991 • 768 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages

1983 • 689 citations

Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

1983 • 651 citations

Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.

1984 • 624 citations

Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone

1983 • 622 citations

Protamine is an inhibitor of angiogenesis

1982 • 582 citations

Presence of heparan sulfate in the glomerular basement membrane

1979 • 562 citations

Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics

1985 • 532 citations

The mast cells

1965 • 520 citations

Vasculae Reactions of Normal and Malignant Tissues in Vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic Transplants

1945 • 466 citations

Mast cell heparin stimulates migration of capillary endothelial cells in vitro.

1980 • 445 citations

A simple procedure for the long-term cultivation of chicken embryos

1974 • 436 citations

Biology of Endothelial Cells

1984 • 426 citations

Relation of vascular proliferation to tumor growth.

1976 • 413 citations

Heparin Binds Endothelial Cell Growth Factor, the Principal Endothelial Cell Mitogen in Bovine Brain

1984 • 391 citations

Inhibition of tumor angiogenesis mediated by cartilage.

1975 • 361 citations

The use of silicone rubber as a carrier for prolonged drug therapy

1964 • 343 citations

Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase.

1982 • 312 citations

Isolations of a Cartilage Factor That Inhibits Tumor Neovascularization

1976 • 308 citations

Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography

1984 • 298 citations

Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction.

1975 • 285 citations

Growth and maturation factors

1983 • 269 citations

Mast cells and tumor angiogenesis

1976 • 267 citations

Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.

1983 • 261 citations

Polymers for Sustained Macromolecule Release: Procedures to Fabricate Reproducible Delivery Systems and Control Release Kinetics

1980 • 254 citations

Preservation of Vascular Integrity in Organs perfused in vitro with a Platelet-rich Medium

1969 • 249 citations

Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor.

1970 • 243 citations

Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber

1939 • 232 citations

Migration of capillary endothelial cells is stimulated by tumour-derived factors

1980 • 227 citations

Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities.

1984 • 224 citations

Growth and metastasis of tumor in organ culture

1963 • 220 citations

Heparin affinity of anionic and cationic capillary endothelial cell growth factors: analysis of hypothalamus-derived growth factors and fibroblast growth factors.

1985 • 214 citations

The observation of heparin on endothelium after injection

1976 • 180 citations

Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia

1977 • 161 citations

Tumor angiogenesis activity in cells grown in tissue culture.

1976 • 159 citations

Enzymatic degradation of heparin-related mucopolysaccharides from the surface of endothelial cell cultures

1975 • 157 citations

Chemotherapy of cancer dissemination and metastasis

1973 • 136 citations

The resistance of certain tissues to invasion: penetrability of explanted tissues by vascularized mesenchyme.

1973 • 135 citations

The stimulation of DNA synthesis and cell division in chondrocytes and 3T3 cells by a growth factor isolated from cartilage

1977 • 131 citations

Purification of cartilage-derived growth factor by heparin affinity chromatography.

1985 • 129 citations

An Enzymatic System for Removing Heparin in Extracorporeal Therapy

1982 • 125 citations

Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes.

1982 • 123 citations

Magnetic modulation of release of macromolecules from polymers.

1981 • 122 citations

Human vascular endothelial cells in culture *1Lack of response to serum growth factors

1976 • 118 citations

Collagenase and collagenase inhibitors in osteoarthritic and normal cartilage.

1977 • 109 citations

Development of the vascular system in the hamster malignant neurilemmoma

1973 • 101 citations

Differential anticoagulant activity of heparin fragments prepared using microbial heparinase.

1982 • 94 citations

The influence of oxygen on viability and proliferation in cellular spheroids

1979 • 85 citations

Purification of a cartilage-derived growth factor.

1980 • 81 citations

HETEROLOGOUS TRANSPLANTATION OF MAMMALIAN TUMORS

1941 • 78 citations

A micro sustained release system for epidermal growth factor

1983 • 77 citations

Tumor angiogenic factor. Purification from the Walker 256 rat tumor.

1981 • 76 citations

Isolation of the nonhistone proteins of rat Walker carcinoma 256. Their association with tumor angiogenesis

1973 • 70 citations

Angiogenesis-dependent tumor spread in reinforced fibrin clot culture.

1983 • 69 citations

Mouse bone collagenase

1973 • 69 citations

Tumour angiogenesis factor (TAF) in human and animal tumours

1976 • 67 citations

The spread of cancer.

1957 • 47 citations

Endothelial regeneration: studies with human endothelial cells in culture.

1973 • 47 citations

Plasma and cellular modulatory proteins

1983 • 32 citations

Human lung tumour cell line adapted to grow in serum‐free medium secretes angiogenesis factor

1983 • 23 citations

Stimulation of increased capillary endothelial cell motility by chondrosarcoma cell-derived factors.

1983 • 13 citations

<i>In Vivo</i> and Electron Microscopic Study of Vessels in a Haemangiopericytoma of the Hamster

1968 • 10 citations