Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

Dose: A critical factor in cancer chemotherapy

1980 • 851 citations

The central nervous system in childhood leukemia.II. Subacute leukoencephalopathy

1975 • 484 citations

Adriamycin chemotherapy—efficacy, safety, and pharmacologic basis of an intermittent single high-dosage schedule

1974 • 393 citations

Disseminated necrotizing leukoencephalopathy: A complication of treated central nervous system leukemia and lymphoma

1975 • 391 citations

Blood-brain barrier in physiology and medicine

1977 • 364 citations

Abnormal CT Scans of the Brain in Asymptomatic Children with Acute Lymphocytic Leukemia after Prophylactic Treatment of the Central Nervous System with Radiation and Intrathecal Chemotherapy

1978 • 297 citations

Quantitative aspects of reversible osmotic opening of the blood-brain barrier

1980 • 276 citations

Management of central nervous system metastases

2020 • 272 citations

Neurologic sequelae of methotrexate and ionizing radiation: a new classification.

1981 • 271 citations

Chemotherapy of Brain Tumors

1977 • 196 citations

The central nervous system in childhood leukemia. I

1973 • 195 citations

Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier.

1982 • 184 citations

Therapeutic Efficacy of Multiagent Chemotherapy with Drug Delivery Enhancement by Blood-Brain Barrier Modification in Glioblastoma

1986 • 166 citations

Reversible Osmotic Blood-Brain Barrier Disruption in Humans

1980 • 163 citations

Central nervous system involvement by ovarian carcinoma.A complication of prolonged survival with metastatic disease

1978 • 134 citations

Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery.

1979 • 130 citations

Developments in the diagnosis and treatment of primary CNS lymphoma: A prospective series

1986 • 123 citations

Experimental Study of Contrast Media for Cerebral Angiography with Reference to Possible Injurious Effects on the Cerebral Blood Vessels

1949 • 116 citations

Monitoring of Methotrexate Delivery in Patients with Malignant Brain Tumors After Osmotic Blood-Brain Barrier Disruption

1981 • 104 citations

Changes of the blood-brain barrier in experimental metastatic brain tumors

1983 • 103 citations

Successful Treatment of Primary Central Nervous System Lymphomas with Chemotherapy after Osmotic Blood-Brain Barrier Opening

1983 • 99 citations

Pharmacology and toxicity of intracarotid adriamycin administration following osmotic blood-brain barrier modification.

1981 • 96 citations

Diagnosis and treatment of metastases to the brain.

1974 • 92 citations

Effect of Osmotic Blood-Brain Barrier Disruption on Methotrexate Pharmacokinetics in the Dog

1980 • 90 citations

Increased incidence of cerebral metastases in sarcoma patients with prolonged survival from chemotherapy.Report of cases of leiomysarcoma and chondrosarcoma

1975 • 86 citations

Chemotherapy of brain metastases: Current status

1984 • 84 citations

Increased incidence of brain metastases in sarcoma patients

1980 • 82 citations

Osmotic Blood-Brain Barrier Modification and Combination Chemotherapy: Concurrent Tumor Regression in Areas of Barrier Opening and Progression in Brain Regions Distant to Barrier Opening

1984 • 80 citations

Regional Blood Flow and Blood-to-Tissue Transport in Five Brain Tumor Models

2015 • 78 citations

Growth of human lung tumor in the brain of the nude rat as a model to evaluate antitumor agent delivery across the blood-brain barrier.

1985 • 73 citations

Delivery of a Quaternary Pyridinium Salt Across the Blood-Brain Barrier by Its Dihydropyridine Derivative

1975 • 71 citations

Osmotic Blood-Brain Barrier Modification: Monoclonal Antibody, Albumin, and Methotrexate Delivery to Cerebrospinal Fluid and Brain

1985 • 71 citations

The management of brain metastases in germ cell tumors

1982 • 71 citations

Potential central nervous system antitumor agents. Hydantoin derivatives

1975 • 63 citations

Osmotic blood-brain barrier disruption in the posterior fossa of the dog

1981 • 58 citations

Childhood Brain Tumors: Current Status of Clinical Trials in Newly Diagnosed and Recurrent Disease

1985 • 56 citations

Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning

1983 • 55 citations

Use of Enhanced Computerized Tomography to Evaluate Osmotic Blood-Brain Barrier Disruption

1980 • 52 citations

Chemotherapeutic Agent Permeability to Normal Brain and Delivery to Avian Sarcoma Virus-induced Brain Tumors in the Rodent: Observations on Problems of Drug Delivery

1984 • 45 citations

Management of brain metastases from breast cancer by combination chemotherapy

1983 • 45 citations

Enhancement of CNS penetration of methotrexate by hyperosmolar intracarotid mannitol or carcinomatous meningitis

1979 • 44 citations

Permeability of human brain tumor to 99mTc-glucoheptonate and 99mTc-albumin

1986 • 44 citations

Chemotherapy in the treatment of malignant brain tumors.

1975 • 43 citations

Osmotic opening of the blood-brain barrier to methotrexate in the rat.

1979 • 42 citations

Uptake and Distribution of <sup>3</sup>H-Methotrexate by the Murine Ependymoblastoma

1972 • 37 citations

Histological observations on the regrowth of malignant gliomas after radiotherapy and chemotherapy

1982 • 37 citations

Developments in the diagnosis and treatment of primary CNS lymphoma

1986 • 36 citations

Elimination of a Quaternary Pyridinium Salt Delivered as Its Dihydropyridine Derivative from Brain of Mice

1978 • 32 citations

Osmotic blood-brain barrier modification: Clinical documentation by enhanced CT scanning and/or radionuclide brain scanning

1983 • 18 citations

External carotid artery infusion with single-and multiple-drug regimens in the rat

1980 • 18 citations

Pathologic Effects of Chemotherapy

1983 • 16 citations