Prospects for therapeutic vaccination with glatiramer acetate for neurodegenerative diseases such as Alzheimer's disease

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

Nitric oxide, mitochondria and neurological disease

1999 • 474 citations

Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences

2001 • 470 citations

Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide

1971 • 431 citations

Neurodegenerative disorders: the role of peroxynitrite

1999 • 414 citations

Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

2000 • 412 citations

Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

2000 • 393 citations

Passive or Active Immunization with Myelin Basic Protein Promotes Recovery from Spinal Cord Contusion

2000 • 368 citations

The link between excitotoxic oligodendroglial death and demyelinating diseases

2001 • 345 citations

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies

2000 • 312 citations

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

2000 • 304 citations

Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaucoma

2001 • 293 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

Mechanisms of action of glatiramer acetate in multiple sclerosis

2001 • 252 citations

Mitochondrial dysfunction in Parkinson's disease

1999 • 245 citations

Therapeutic inhibition of the complement system.

1998 • 242 citations

Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat: a cytochrome oxidase histochemistry study

1991 • 241 citations

Acute Neuronal Apoptosis in a Rat Model of Multiple Sclerosis

2001 • 233 citations

Neuronal Survival after CNS Insult Is Determined by a Genetically Encoded Autoimmune Response

2001 • 231 citations

Neuroprotection and neurodegenerative disease

2002 • 227 citations

Degeneration of Spared Axons Following Partial White Matter Lesion: Implications for Optic Nerve Neuropathies

1998 • 214 citations

Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease

2001 • 205 citations

Autoimmunity can benefit self-maintenance

2000 • 190 citations

Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1

1998 • 176 citations

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

1995 • 174 citations

Genetic models for CNS inflammation

2001 • 168 citations

Increased glutamate in CSF and plasma of patients with HIV dementia

2001 • 165 citations

Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries

2001 • 164 citations

Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease

2001 • 163 citations

Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor

1998 • 157 citations

Vaccination for Neuroprotection in the Mouse Optic Nerve: Implications for Optic Neuropathies

2001 • 156 citations

Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses

1996 • 155 citations

Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis.

1995 • 153 citations

Effects of estrogen treatment on glutamate uptake in cultured human astrocytes derived from cortex of Alzheimer's disease patients

2002 • 133 citations

Treatment of multiple sclerosis with Copaxone (COP): Elispot assay detects COP-induced interleukin-4 and interferon-gamma response in blood cells

2001 • 115 citations

Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: Implications for protective autoimmunity

2002 • 97 citations

Bromocriptine in rheumatic and autoimmune diseases

2001 • 97 citations

Potential treatment modalities for glaucomatous neuropathy: neuroprotection and neuroregeneration.

1996 • 95 citations

T suppressor hybridomas and interleukin‐2‐dependent lines induced by copolymer 1 or by spinal cord homogenate down‐regulate experimental allergic encephalomyelitis

1993 • 88 citations

Glia-T cell dialogue

2000 • 86 citations

Nasal Vaccination withβ-Amyloid Peptide for the Treatment of Alzheimer's Disease

2001 • 84 citations

Copolymer 1: from basic research to clinical application

1997 • 73 citations

T-cell-based immunity counteracts the potential toxicity of glutamate in the central nervous system

2001 • 71 citations

Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients

2000 • 70 citations

The Tissue-Specific Self-Pathogen Is the Protective Self-Antigen: The Case of Uveitis

2002 • 69 citations

Axon damage and repair in multiple sclerosis

1999 • 66 citations

Multiple sclerosis: comparison of the human T-cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis

1997 • 56 citations

Therapeutic inhibition of the complement system. Y2K update

2000 • 55 citations

Multiple Sclerosis as a By-Product of the Failure to Sustain Protective Autoimmunity: A Paradigm Shift

2002 • 52 citations

Potential Treatment Modalities for Glaucomatous Neuropathy

1996 • 51 citations

Oral tolerance with Copolymer 1 for the treatment of multiple sclerosis

1999 • 50 citations

Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease

1997 • 39 citations

Binding of copolymer 1 and myelin basic protein leads to clustering of class II MHC molecules on antigen-presenting cells

1997 • 36 citations

Genetics of rat neuroinflammation

2000 • 35 citations

Degeneracy, as opposed to specificity, in immunotherapy

2002 • 33 citations

Beyond Intraocular Pressure: Neuroprotective Strategies for Future Glaucoma Therapy

2001 • 30 citations

Degeneracy, as opposed to specificity, in immunotherapy

2002 • 27 citations

Persistent expression of experimental autoimmune encephalomyelitis (EAE)-specific Vbeta8.2 TCR spectratype in the central nervous system of rats with chronic relapsing EAE.

1998 • 26 citations

Immunotherapy with β-Amyloid for Alzheimer's Disease: A New Frontier

2001 • 25 citations

Specific vaccines against autoimmune diseases

1999 • 24 citations

Intense immune suppression for systemic lupus--the role of hematopoietic stem cells.

2000 • 23 citations

Persistent Expression of Experimental Autoimmune Encephalomyelitis (EAE)-Specific Vβ8.2 TCR Spectratype in the Central Nervous System of Rats with Chronic Relapsing EAE

1998 • 22 citations

The Concept of Specific Immune Treatment Against Autoimmune Diseases

1999 • 18 citations

Cop 1 as a candidate drug for multiple sclerosis

1997 • 15 citations

Immunoassay for Serum Glutamine Synthetase in Serum: Development, Reference Values, and Preliminary Study in Dementias

2002 • 14 citations

Immunosuppressive Applications of PHA and Other Plant Mitogens

1998 • 10 citations

Oral toleragens in rheumatoid arthritis.

2000 • 9 citations