Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Inflammation and Alzheimer's disease

2000 • 4,315 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

2000 • 1,954 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

2000 • 1,433 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

2000 • 1,259 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

1996 • 563 citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1995 • 521 citations

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

1998 • 513 citations

Laying it on thick

1999 • 471 citations

Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

2001 • 453 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

1999 • 369 citations

Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation

1999 • 356 citations

Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

1996 • 328 citations

Oral Tolerance: Mechanisms and Therapeutic Applications

1999 • 318 citations

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

2000 • 307 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease

2000 • 252 citations

Complement-dependent Proinflammatory Properties of the Alzheimer's Disease β-Peptide

1998 • 240 citations

The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis

2000 • 234 citations

The role of CD8⁺ T cells in the initiation of insulin‐dependent diabetes mellitus

1996 • 225 citations

Induction of Self-Rolerance in T Cells But Not B Cells of Transgenic Mice Expressing Little Self Antigen

1991 • 211 citations

Autoimmunity can benefit self-maintenance

2000 • 190 citations

Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia

1997 • 153 citations

The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis

2006 • 104 citations

Quantitative Analysis of the T Cell Repertoire that Escapes Negative Selection

1999 • 103 citations

APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's Disease

1996 • 101 citations

Plasma Levels of amyloid β proteins Aβ1–40 and Aβ1–42(43) are elevated in Down's syndrome

1997 • 93 citations

Mechanisms of cell death in Alzheimer disease — immunopathology

1998 • 78 citations

Epithelial and endothelial expression of the green fluorescent protein reporter gene under the control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice

2000 • 74 citations

Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines

1999 • 67 citations

GAD65-Reactive T cells in a Non-diabetic Stiff-man Syndrome Patient

1999 • 51 citations

Hen egg-white lysozyme-specific T cells elicited in hen egg-white lysozyme-transgenic mice retain an imprint of self-tolerance.

1993 • 35 citations

Key issues in Alzheimer's disease inflammation

2000 • 35 citations

T-cell development: A role for self-peptides in positive selection

1999 • 26 citations