Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

2008 • 1,304 citations

Adoptive T cell therapy using antigen-specific CD8⁺T cell clones for the treatment of patients with metastatic melanoma:In vivopersistence, migration, and antitumor effect of transferred T cells

2002 • 1,187 citations

Late Developmental Plasticity in the T Helper 17 Lineage

2009 • 1,022 citations

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

2005 • 1,000 citations

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

2009 • 923 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

2005 • 916 citations

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

2005 • 894 citations

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

2008 • 883 citations

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

2009 • 882 citations

Tumor-specific Th17-polarized cells eradicate large established melanoma

2008 • 792 citations

CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

2005 • 741 citations

The role of CD4+ T cell responses in antitumor immunity

1998 • 678 citations

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

2006 • 677 citations

Adoptive T cell therapy for cancer in the clinic

2007 • 536 citations

Primary Antitumor Immune Response Mediated by CD4+ T Cells

2005 • 444 citations

Principles and use of anti-CTLA4 antibody in human cancer immunotherapy

2006 • 437 citations

CD4 cells can be more efficient at tumor rejection than CD8 cells

2007 • 411 citations

CD4⁺T cells eliminate MHC class II-negative cancer cellsin vivoby indirect effects of IFN-γ

1999 • 378 citations

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

2009 • 361 citations

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

2007 • 353 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?

2006 • 333 citations

Workshop R: Tumor Immunology, Abstract R1 bis R30

2001 • 312 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

2005 • 294 citations

Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia

2003 • 286 citations

Bystander elimination of antigen loss variants in established tumors

2004 • 259 citations

Adoptive immunotherapy of cancer using CD4+ T cells

2009 • 218 citations

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

2008 • 206 citations

Regulation of transcription of MHC class II genes

1997 • 199 citations

Epstein-Barr Nuclear Antigen 1-Specific CD4+ Th1 Cells Kill Burkitt’s Lymphoma Cells

2002 • 168 citations

Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells

2008 • 153 citations

Self-antigen–specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response

2009 • 108 citations

Virus-specific CD4+ T cells: ready for direct attack

2006 • 88 citations

Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells

2007 • 88 citations

Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL

2005 • 80 citations

Lack of specific γ-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation

2009 • 65 citations

Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel genome-wide analysis

2008 • 64 citations

The Balance Between Donor T Cell Anergy and Suppression Versus Lethal Graft-Versus-Host Disease Is Determined by Host Conditioning

2002 • 42 citations

HLA-DMB expression by thyrocytes: indication of the antigen-processing and possible presenting capability of thyroid cells

1999 • 26 citations

A class II‐restricted cytotoxic T‐cell clone recognizes a human minor histocompatibility antigen with a restricted tissue distribution

2004 • 20 citations

CD4+ T Cells Cooperate With Macrophages for Specific Elimination of MHC Class II-Negative Cancer Cells

2007 • 15 citations

Transcriptional regulation of the MHC II gene DRA in untransformed human thyrocytes

2000 • 5 citations