Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H ₂ O ₂

Superoxide Dismutase

1969 • 12,578 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

Superoxide Dismutases

1975 • 1,673 citations

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters

1997 • 1,281 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

Simulation of Multiple Isotropic Spin-Trap EPR Spectra

1994 • 925 citations

Spin trapping

1971 • 829 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Inactivation of the enzyme

1975 • 777 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1997 • 593 citations

Epidemiology of mutations in superoxide dismutase in amyotrophic lateal sclerosis

1997 • 517 citations

5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: A New Efficient Phosphorylated Nitrone for the in Vitro and in Vivo Spin Trapping of Oxygen-Centered Radicals

1995 • 505 citations

Decreased Zinc Affinity of Amyotrophic Lateral Sclerosis‐Associated Superoxide Dismutase Mutants Leads to Enhanced Catalysis of Tyrosine Nitration by Peroxynitrite

1997 • 483 citations

Transmembrane Protein Structure: Spin Labeling of Bacteriorhodopsin Mutants

1990 • 465 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

The loop-gap resonator: a new microwave lumped circuit ESR sample structure

1982 • 456 citations

The Origin of the Hydroxyl Radical Oxygen in the Fenton Reaction

1997 • 406 citations

Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus Heterogeneity

1991 • 373 citations

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

1995 • 334 citations

Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase.

1992 • 299 citations

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant

1997 • 287 citations

Enzyme function of copper, zinc superoxide dismutase as a free radical generator.

1993 • 224 citations

Characterization of Sulfur-centered Radical Intermediates Formed during the Oxidation of Thiols and Sulfite by Peroxynitrite

1996 • 222 citations

[9] Spin-trapping methods for detecting superoxide and hydroxyl free radicals in vitro and in vivo

1990 • 195 citations

Superoxide anion formation from lucigenin: an electron spin resonance spin‐trapping study

1997 • 192 citations

Hydroxyl Radical Formation from Cuprous Ion and Hydrogen Peroxide: A Spin-Trapping Study

1995 • 182 citations

Inactivation of the human CuZn superoxide dismutase during exposure to O2− and H2O2

1981 • 176 citations

A Familial Amyotrophic Lateral Sclerosis-associated A4V Cu,Zn-Superoxide Dismutase Mutant Has a Lower K for Hydrogen Peroxide

1997 • 150 citations

When are metal ion-dependent hydroxyl and alkoxyl radical adducts of 5,5-dimethyl-1-pyrroline N-oxide artifacts?

1992 • 117 citations

Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease

1996 • 101 citations

5-Diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO): a new phosphorylated nitrone for the efficient In Vitro and In Vivo spin trapping of oxygen-centred radicals

1994 • 98 citations

Normal Binding and Reactivity of Copper in Mutant Superoxide Dismutase Isolated from Amyotrophic Lateral Sclerosis Patients

1997 • 95 citations

Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers

1994 • 65 citations

The interaction between Cu(I) superoxide dismutase and hydrogen peroxide

1989 • 60 citations

Motor neurone disease and animal models

1994 • 58 citations

Reversible loss of metal ions from the zinc binding site of copper-zinc superoxide dismutase. The low pH transition

1979 • 55 citations

Inhibition of radical adduct reduction and reoxidation of the corresponding hydroxylamines in in vivo spin trapping of carbon tetrachloride-derived radicals

1992 • 44 citations

Superoxide-Dependent Peroxidase Activity of H48Q: A Superoxide Dismutase Variant Associated with Familial Amyotrophic Lateral Sclerosis

1997 • 44 citations

Amyotrophic lateral sclerosis: human challenge for neuroscience.

1995 • 40 citations

MOLECULAR APPROACHES TO AMYOTROPHIC LATERAL SCLEROSIS

1995 • 33 citations

Cell death mechanisms in ALS

1996 • 19 citations

Radical cations from nitrone spin-traps: reaction with water to give OH adducts

1996 • 19 citations

ALS: molecular clues to the jigsaw puzzle of neuronal degeneration.

1996 • 12 citations