Cadmium Induces Conformational Modifications of Wild-type p53 and Suppresses p53 Response to DNA Damage in Cultured Cells

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

p53 and Human Cancer: The First Ten Thousand Mutations

1999 • 968 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

The p53 Network

1998 • 731 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Cadmium, Gene Regulation, and Cellular Signalling in Mammalian Cells

1997 • 530 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Genetic determinants of p53-induced apoptosis and growth arrest.

1996 • 472 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Structural Aspects of Metal Liganding to Functional Groups in Proteins

1991 • 454 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Toxicological Principles of Metal Carcinogenesis with Special Emphasis on Cadmium

1992 • 285 citations

Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro

1990 • 283 citations

Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells

1997 • 260 citations

A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

1995 • 242 citations

In vivo measurement of liver and kidney cadmium in workers exposed to this metal: Its significance with respect to cadmium in blood and urine

1981 • 205 citations

Effect of replacement of “zinc finger” zinc on estrogen receptor DNA interactions.

1992 • 197 citations

Activation of the cryptic DNA binding function of mutant forms of p53

1993 • 190 citations

Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.

1997 • 188 citations

Disruption of the Intracellular Sulfhydryl Homeostasis by Cadmium-induced Oxidative Stress Leads to Protein Thiolation and Ubiquitination in Neuronal Cells

1998 • 187 citations

The DNA Binding Activity of Metal Response Element-binding Transcription Factor-1 Is Activated in vivo and in Vitro by Zinc, but Not by Other Transition Metals

1998 • 186 citations

Multisite Phosphorylation and the Integration of Stress Signals at p53

1998 • 185 citations

A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

1993 • 182 citations

Regulation of p53 by Metal Ions and by Antioxidants: Dithiocarbamate Down-Regulates p53 DNA-Binding Activity by Increasing the Intracellular Level of Copper

1997 • 169 citations

A Structural Basis for Metal Ion Mutagenicity and Nucleotide Selectivity in Human DNA Polymerase β^,

1996 • 158 citations

Involvement of p85 in p53-dependent apoptotic response to oxidative stress

1998 • 154 citations

Cadmium-induced DNA strand damage in cultured liver cells: Reduction in cadmium genotoxicity following zinc pretreatment

1992 • 126 citations

Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function.

1990 • 118 citations

Anti-apoptotic activity of low levels of wild-type p53.

1996 • 109 citations

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc

1998 • 109 citations

Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA

1997 • 95 citations

Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector.

1983 • 94 citations

Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function

1997 • 83 citations

Metallothionein-I and -II Knock-Out Mice Are Sensitive to Cadmium-Induced Liver mRNA Expression of c-junandp53

1996 • 82 citations

Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism.

1995 • 80 citations

Transition metals modulate DNA-protein interactions of SP1 zinc finger domains with its cognate target site

1991 • 78 citations

CADMIUM SUPPRESSES APOPTOSIS INDUCED BY CHROMIUM

1998 • 76 citations

Characterization of baculovirus recombinant wild‐type p53

1994 • 72 citations

Inhibition of DNA replication and repair by cadmium in mammalian cells. Protective interaction of zinc

1987 • 66 citations

A functional screen for germ line p53 mutations based on transcriptional activation.

1992 • 66 citations

Association of insulin‐like growth‐factor‐I‐induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF‐7 cells

1993 • 62 citations

Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells.

1996 • 57 citations

INDUCTION OF c-mycAND c-junPROTO-ONCOGENE EXPRESSION IN RAT L6 MYOBLASTS BY CADMIUM IS INHIBITED BY ZINC PREINDUCTION OF THE METALLOTHIONEIN GENE

1996 • 54 citations

Protein synthesis—dependent cytoplasmic translocation of p53 protein after serum stimulation of growth‐arrested MCF‐7 cells

1993 • 39 citations

Cadmium-induced inhibition of the growth and metastasis of human lung carcinoma xenografts: role of apoptosis

1999 • 38 citations

p21WAF1/CIP1 response to genotoxic agents in wild-type TP53 expressing breast primary tumours

1997 • 35 citations

Sequence-specific interaction of a conformational domain of p53 with DNA.

1993 • 25 citations

Role of Charge in the Radioprotection ofE. Coliby Thiols

1995 • 21 citations

In vivo measurement of critical level of kidney cadmium: Dose effect studies in cadmium smelter workers

1980 • 20 citations

Divalent metal ions induce conformational change in pure, human wild-type p53 tumor suppressor protein

1994 • 19 citations