A functional screen for germ line p53 mutations based on transcriptional activation.

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

p53 function and dysfunction

1992 • 1,918 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

1990 • 313 citations

Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma

1992 • 304 citations

Inherited p53 gene mutations in breast cancer.

1992 • 255 citations

Mammalian p53 can function as a transcription factor in yeast

1992 • 182 citations

p53 germline mutations in Li-Fraumeni syndrome

1991 • 132 citations

Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma.

1991 • 124 citations

A germ line mutation in exon 5 of the p53 gene in an extended cancer family.

1991 • 97 citations

Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.

1992 • 96 citations

Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line.

1989 • 94 citations

Cancer risks from germline p53 mutations.

1992 • 89 citations

Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma.

1992 • 72 citations

Detection of both mutant and wild-type p53 protein in normal skin fibroblasts and demonstration of a shared 'second hit' on p53 in diverse tumors from a cancer-prone family with Li-Fraumeni syndrome.

1992 • 48 citations