An Autocrine Function for Transforming Growth Factor (TGF)-β3 in the Transformation of Atrioventricular Canal Endocardium into Mesenchyme during Chick Heart Development

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

Structural development of endocardial cushions

1977 • 468 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action

1988 • 347 citations

Embryonic development of the heart. I. A light and electron microscopic study of myocardial development in the early chick embryo

1968 • 347 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor β

1989 • 286 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Invasion of mesenchyme into three-dimensional collagen gels: A regional and temporal analysis of interaction in embryonic heart tissue

1983 • 265 citations

Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3.

1991 • 263 citations

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

1993 • 241 citations

Developmental cardiology : morphogenesis and function

1990 • 240 citations

TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis

1990 • 239 citations

Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.

1996 • 236 citations

Complementary Deoxyribonucleic Acid Cloning of a Messenger Ribonucleic Acid Encoding Transforming Growth Factor β 4 from Chicken Embryo Chondrocytes

1988 • 227 citations

Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.

1996 • 222 citations

The Development of the Atrioventricular Junction in the Human Heart

1996 • 203 citations

SEQUENCES OF INTEREST: Complementary Deoxyribonucleic Acid Cloning of a Novel Transforming Growth Factor-β Messenger Ribonucleic Acid from Chick Embryo Chondrocytes

1988 • 191 citations

Migratory behavior of cardiac cushion tissue cells in a collagen-lattice culture system

1982 • 179 citations

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.

1993 • 177 citations

Cardiovascular health and disease in children: current status. A Special Writing Group from the Task Force on Children and Youth, American Heart Association.

1994 • 171 citations

RNA and protein localisations of TGFβ2 in the early mouse embryo suggest an involvement in cardiac development

1993 • 166 citations

Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.

1990 • 162 citations

Myocardial specificity for initiating endothelial-mesenchymal cell transition in embryonic chick heart correlates with a particulate distribution of fibronectin

1987 • 158 citations

Structural analyses on the matrical organization of glycosaminoglycans in developing endocardial cushions

1978 • 148 citations

Induction of an epithelial-mesenchymal transition by an in vivo adheron-like complex

1989 • 144 citations

Extracellular matrix from embryonic myocardium elicits an early morphogenetic event in cardiac endothelial differentiation

1987 • 129 citations

Antibodies to the Type II TGFβ Receptor Block Cell Activation and Migration during Atrioventricular Cushion Transformation in the Heart

1996 • 126 citations

Extracellular Fibrillar Structure of Latent TGFβ Binding Protein-1: Role in TGFβ-dependent Endothelial-Mesenchymal Transformation during Endocardial Cushion Tissue Formation in Mouse Embryonic Heart

1997 • 123 citations

The primitive cardiac regions in the straight tube heart (Stage 9) and their anatomical expression in the mature heart: An experimental study in the chick embryo.

1989 • 123 citations

Distribution of basement membrane antigens in cryopreserved early embryonic hearts

1987 • 121 citations

Transforming growth factor-beta in cardiac ontogeny and adaptation.

1993 • 82 citations

Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction

1992 • 78 citations

Expression of transforming growth factor-β2 and β3 mRNAs and proteins in the developing chicken embryo

1994 • 77 citations

TGF‐β3‐Mediated tissue interaction during embryonic heart development

1992 • 74 citations

Localization of bFGF-like proteins as punctate inclusions in the preseptation myocardium of the chicken embryo

1991 • 73 citations

Myocardial Regulation of Transforming Growth Factor-β Expression by Outflow Tract Endothelium in the Early Embryonic Chick Heart

1994 • 72 citations

Identification of an extracellular 130-kDa protein involved in early cardiac morphogenesis

1993 • 65 citations

An antiserum (ES1) against a particulate form of extracellular matrix blocks the transition of cardiac endothelium into mesenchyme in culture

1991 • 53 citations

Initial expression of type I procollagen in chick cardiac mesenchyme is dependent upon myocardial stimulation

1988 • 48 citations

Fibronectin distribution during early chick embryo heart development

1983 • 43 citations

Urokinase activity in the developing avian heart: A spatial and temporal analysis

1992 • 42 citations

Inductive Interactions in Heart Development

1990 • 42 citations

Expression of collagenase and IL‐1α in developing rat hearts

1992 • 34 citations

Inhibition of outflow cushion mesenchyme formation in retinoic acid-induced complete transposition of the great arteries

1996 • 34 citations

Latent transforming growth factor-β is present in the extracellular matrix of embryonic hearts in situ

1996 • 30 citations

Identification of transferrin as one of multiple EDTA‐extractable extracellular proteins involved in early chick heart morphogenesis

1994 • 30 citations

Growth factors and signal transduction in development

1995 • 29 citations

Transformation of cardiac endothelium into cushion mesenchyme is dependent on ES/130: temporal, spatial, and functional studies in the early chick embryo.

1995 • 27 citations

Hypoplasia of cushion ridges in the proximal outflow tract elicits formation of a right ventricle-to-aortic route in retinoic acid-induced complete transposition of the great arteries in the mouse: Scanning electron microscopic observations of corrosion cast models

1996 • 26 citations

Temporal and spatial asymmetries in the initial distribution of mesenchyme cells in the atrioventricular canal cushions of the developing chick heart

1997 • 24 citations

Transforming growth factor-?1 localized within the heart of the chick embryo

1991 • 19 citations

Growth factors and signal transduction in development

1994 • 18 citations

Deleted Work

1955 • 0 citations