The Functional Metabolism and Molecular Biology of Vitamin D Action

Vitamin D

1979 • 3,814 citations

Decreased bioavailability of vitamin D in obesity

2000 • 3,081 citations

Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

1993 • 2,625 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety

1999 • 1,500 citations

Aging decreases the capacity of human skin to produce vitamin D3.

1985 • 1,404 citations

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

2007 • 1,367 citations

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

2004 • 1,343 citations

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

2004 • 1,286 citations

Unique Biosynthesis by Kidney of a Biologically Active Vitamin D Metabolite

1970 • 1,281 citations

J Soc Gynecol Investig

2005 • 1,243 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

INCREASED SKIN PIGMENT REDUCES THE CAPACITY OF SKIN TO SYNTHESISE VITAMIN D3

1982 • 1,154 citations

25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men<subtitle>A Prospective Study</subtitle>

2008 • 1,132 citations

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

2018 • 1,100 citations

From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health

2008 • 1,002 citations

Noncalcemic Actions of Vitamin D Receptor Ligands

2005 • 962 citations

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

1988 • 961 citations

Intestinal Calcium Absorption and Serum Vitamin D Metabolites in Normal Subjects and Osteoporotic Patients

1979 • 865 citations

The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2000 • 802 citations

Vitamin D: its role and uses in immunology¹

2001 • 790 citations

The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus

1973 • 781 citations

The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis

2000 • 734 citations

Target Cells for 1,25-Dihydroxyvitamin D ₃ in Intestinal Tract, Stomach, Kidney, Skin, Pituitary, and Parathyroid

1979 • 713 citations

Evidence for alteration of the vitamin D-endocrine system in obese subjects.

1985 • 695 citations

Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System

2000 • 694 citations

Control of 25-Hydroxycholecalciferol Metabolism by Parathyroid Glands

1972 • 661 citations

Enzymes involved in the activation and inactivation of vitamin D

2004 • 633 citations

Fibroblast Growth Factor 23 Is a Counter-Regulatory Phosphaturic Hormone for Vitamin D

2006 • 626 citations

Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction

2001 • 623 citations

Sunscreens Suppress Cutaneous Vitamin D₃Synthesis*

1987 • 592 citations

GRIP1, a Transcriptional Coactivator for the AF-2 Transactivation Domain of Steroid, Thyroid, Retinoid, and Vitamin D Receptors

1997 • 572 citations

The pharmacokinetics of Norpace.

1975 • 567 citations

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

2004 • 556 citations

Calcium in biological systems

1976 • 550 citations

Optimal Vitamin D Status for Colorectal Cancer Prevention

2007 • 542 citations

Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat.

1986 • 530 citations

The Mode of Action of Vitamin K

1974 • 527 citations

Regulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone

1973 • 525 citations

A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma

1976 • 515 citations

Pathogenic role of Fgf23 in Hyp mice

2006 • 478 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

Vitamin D and prevention of breast cancer: Pooled analysis

2007 • 457 citations

Evidence for alteration of the vitamin D-endocrine system in blacks.

1985 • 457 citations

STUDIES ON EXPERIMENTAL RICKETS

1922 • 454 citations

Regulation by Calcium of In Vivo Synthesis of 1,25-Dihydroxycholecalciferol and 21,25-Dihydroxycholecalciferol

1971 • 443 citations

VITAMIN D: RECENT ADVANCES

1983 • 437 citations

Pathogenesis of Hereditary Vitamin-D-Dependent Rickets

1973 • 426 citations

1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene

1989 • 418 citations

Hypercalcemia in an Anephric Patient with Sarcoidosis: Evidence for Extrarenal Generation of 1,25-Dihydroxyvitamin D

1981 • 417 citations

Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3.

1989 • 409 citations

Cloning of Human 25-Hydroxyvitamin D-1α-Hydroxylase and Mutations Causing Vitamin D-Dependent Rickets Type 1

1997 • 398 citations

Low circulating vitamin D in obesity

1988 • 396 citations

Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.

1992 • 395 citations

Targeted Inactivation of the 25-Hydroxyvitamin D3-1α-Hydroxylase Gene (CYP27B1) Creates an Animal Model of Pseudovitamin D-Deficiency Rickets*

2001 • 385 citations

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

1994 • 383 citations

FAT-SOLUBLE VITAMINS

1934 • 377 citations

Regulation of Serum 1α,25-Dihydroxyvitamin D ₃ by Calcium and Phosphate in the Rat

1975 • 369 citations

Inactivating Mutations in the 25-Hydroxyvitamin D₃1α-Hydroxylase Gene in Patients with Pseudovitamin D–Deficiency Rickets

1998 • 360 citations

Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency.

1984 • 360 citations

Effect of Chronic Anticonvulsant Therapy on Serum 25-Hydroxycalciferol Levels in Adults

1972 • 357 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

Seasonal Changes in Human Plasma Levels of 25-Hydroxyvitamin D

1974 • 343 citations

Nutritional status in a healthy elderly population: vitamin C

1982 • 342 citations

A new mechanism for induced vitamin D deficiency in calcium deprivation

1987 • 341 citations

Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries.

1989 • 340 citations

Vitamin-D-Dependent Rickets Type II

1978 • 340 citations

Vitamin D and Placental-Decidual Function

2004 • 335 citations

Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.

1993 • 328 citations

Active transport of Ca⁴⁵ by the small intestine and its dependence on vitamin D

1959 • 326 citations

24, 25-Dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation

1978 • 323 citations

DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3.

1990 • 322 citations

Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation.

1979 • 322 citations

Deficient Mineralization of Intramembranous Bone in Vitamin D-24-Hydroxylase-Ablated Mice Is Due to Elevated 1,25-Dihydroxyvitamin D and Not to the Absence of 24,25-Dihydroxyvitamin D*

2000 • 321 citations

The 25-Hydroxyvitamin D 1-Alpha-Hydroxylase Gene Maps to the Pseudovitamin D-Deficiency Rickets (PDDR) Disease Locus

1997 • 318 citations

The Importance of Phosphate in Regulating Plasma 1,25-(OH)₂-Vitamin D Levels in Humans: Studies in Healthy Subjects, in Calcium-Stone Formers and in Patients with Primary Hyperparathyroidism*

1977 • 313 citations

Phenobarbital-Induced Alterations in Vitamin D Metabolism

1972 • 308 citations

Biologically active metabolite of vitamin D3 from bone, liver, and blood serum

1966 • 306 citations

Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D

1993 • 305 citations

H<scp>YDROXYLASE</scp>E<scp>NZYMES OF THE</scp>V<scp>ITAMIN</scp>D P<scp>ATHWAY</scp>: Expression, Function, and Regulation

2002 • 300 citations

Heilung von Rachitis durch künstliche Höhensonne

1919 • 299 citations

Vitamin D Metabolism: The Role of Kidney Tissue

1971 • 293 citations

The role of 1 alpha, 25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria.

1977 • 290 citations

Vitamin D: Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism

1983 • 287 citations

Racial Pigmentation and the Cutaneous Synthesis of Vitamin D

1991 • 284 citations

Cloning of the human 1α,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements

1995 • 281 citations

Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans.

1986 • 269 citations

Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat

1971 • 264 citations

Vitamin D: Two Dihydroxylated Metabolites Are Required for Normal Chicken Egg Hatchability

1978 • 263 citations

Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene

1998 • 263 citations

Calcium Transport in Perfused Duodena from Normal Chicks: Enhancement within Fourteen Minutes of Exposure to 1,25-Dihydroxyvitamin D₃*

1984 • 262 citations

Radioligand receptor assay for 25-hydroxyvitamin D2/D3 and 1 alpha, 25-dihydroxyvitamin D2/D3.

1976 • 259 citations

Gene Expression of Osteoprotegerin Ligand, Osteoprotegerin, and Receptor Activator of NF-κB in Giant Cell Tumor of Bone

2000 • 251 citations

Parathyroid hormone activation of the 25-hydroxyvitamin D ₃ -1α-hydroxylase gene promoter

1998 • 250 citations

FAT-SOLUBLE VITAMINS

1924 • 250 citations

Vitamin D status and bone histomorphometry in gross obesity

1981 • 250 citations

Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation

1989 • 246 citations

Calcitroic acid, end product of renal metabolism of 1,25-dihydroxyvitamin D3 through the C-24 oxidation pathway

1989 • 245 citations

The Response of Intestinal Calcium Transport to 25-Hydroxy and 1,25-Dihydroxy Vitamin D in Nephrectomized Rats

1972 • 241 citations

Serum 1,25-Dihydroxyvitamin D Levels in Normal Subjects and in Patients with Hereditary Rickets or Bone Disease

1978 • 239 citations

Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.

1991 • 233 citations

Hormonal Control of Calcium Metabolism

1971 • 233 citations

Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene.

1994 • 231 citations

THE ASSAY OF 1α, 25‐DIHYDROXYVITAMIN D₃: PHYSIOLOGIC AND PATHOLOGIC MODULATION OF CIRCULATING HORMONE LEVELS

1976 • 227 citations

Brain Target Sites for 1,25-Dihydroxyvitamin D ₃

1982 • 224 citations

Serum 25-Hydroxycalciferol Levels and Bone Mass in Children on Chronic Anticonvulsant Therapy

1975 • 223 citations

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

2001 • 223 citations

Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat.

1990 • 222 citations

Hyperparathyroidism and 1,25-Dihydroxyvitamin D Deficiency in Mild, Moderate, and Severe Renal Failure*

1988 • 220 citations

Activation of Receptor Activator of NF-κB Ligand Gene Expression by 1,25-Dihydroxyvitamin D₃ Is Mediated through Multiple Long-Range Enhancers

2006 • 219 citations

Nutritional status in a healthy elderly population: vitamin D

1982 • 217 citations

Plasma Levels and Therapeutic Effect of 25-Hydroxycholecalciferol in Epileptic Patients taking Anticonvulsant Drugs

1972 • 215 citations

1,25(OH)2 vitamin D3 sites of action in the brain

1987 • 213 citations

Response of Intestinal Calcium Transport and Bone Calcium Mobilization to 1,25-Dihydroxyvitamin Da in Thyroparathyroidectomized Rats¹

1974 • 212 citations

Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.

1995 • 212 citations

On the Mechanism of Secondary Hyperparathyroidism in Moderate Renal Insufficiency*

1985 • 210 citations

In vitro production of 25-hydroxycholecalciferol

1969 • 207 citations

Intestinal transport of phosphate: action of vitamin D, calcium, and potassium

1961 • 207 citations

Vitamin D: the vitamin and the hormone.

1974 • 206 citations

Calcium absorption and calcium-binding protein in chicks on differing calcium and phosphorus intakes

1971 • 205 citations

AN EXPERIMENTAL INVESTIGATION ON RICKETS

2009 • 204 citations

A new analog of calcitriol, 19-nor-1,25-(OH)2D2, suppresses parathyroid hormone secretion in uremic rats in the absence of hypercalcemia

1995 • 201 citations

Distinct Conformational Changes Induced by 20-epi Analogues of 1α,25-Dihydroxyvitamin D3 Are Associated with Enhanced Activation of the Vitamin D Receptor

1995 • 201 citations

THE RELATIONSHIP BETWEEN VITAMIN D AND PARATHYROID HORMONE*

1963 • 200 citations

Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in vivo.

1990 • 200 citations

Studies of Vitamin D Deficiency in Man

1975 • 199 citations

Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3.

1990 • 197 citations

Stimulation of 24,25-Dihydroxyvitamin D ₃ Production by 1,25-Dihydroxyvitamin D ₃

1974 • 192 citations

Dietary Phosphate Deprivation in Women and Men: Effects on Mineral and Acid Balances, Parathyroid Hormone and the Metabolism of 25-OH-Vitamin D*

1976 • 191 citations

Stimulation of 25-hydroxyvitamin D3-1alpha-hydroxylase by phosphate depletion.

1976 • 191 citations

Identification of a 1,25-dihydroxyvitamin D3-response element in the 5'-flanking region of the rat calbindin D-9k gene.

1992 • 191 citations

The Government's Present Line on Cardiac Transplantation

1984 • 190 citations

Genetics of Vitamin D 1α-Hydroxylase Deficiency in 17 Families

1998 • 189 citations

Human 25-Hydroxyvitamin D₃-24-Hydroxylase, a Multicatalytic Enzyme

1996 • 189 citations

The role of 1,25‐dihydroxyvitamin D in the mechanism of acquired vitamin D deficiency

1992 • 188 citations

Role of Vitamin D Metabolites in Phosphate Transport of Rat Intestine

1974 • 186 citations

Parathyroid hormone inhibits 25-hydroxyvitamin D3-24-hydroxylase mRNA expression stimulated by 1 alpha,25-dihydroxyvitamin D3 in rat kidney but not in intestine.

1992 • 186 citations

Regulation of Metabolism of 25-Hydroxycholecalciferol by Kidney Tissue in vitro by Dietary Calcium

1972 • 183 citations

Vitamin D Homeostasis in the Perinatal Period

1980 • 183 citations

Molecular Structure of the Rat Vitamin D Receptor Ligand Binding Domain Complexed with 2-Carbon-Substituted Vitamin D₃ Hormone Analogues and a LXXLL-Containing Coactivator Peptide^,

2004 • 182 citations

A Phase I trial of calcitriol (1,25-dihydroxycholecalciferol) in patients with advanced malignancy.

1999 • 181 citations

25-Hydroxyvitamin D3: Evidence of an Enterohepatic Circulation in Man

1975 • 181 citations

SEASONAL VARIATIONS IN SERUM 25-HYDROXYCHOLECALCIFEROL IN HEALTHY PEOPLE

1974 • 179 citations

Metabolism of Vitamin D3-3H in Human Subjects: Distribution in Blood, Bile, Feces, and Urine*

1967 • 178 citations

Control of renal vitamin D hydroxylases in birds by sex hormones.

1976 • 176 citations

The role of 1,25-dihydroxyvitamin D3 and parathyroid hormone in the regulation of chick renal 25-hydroxyvitamin D3-24-hydroxylase

1975 • 175 citations

A potent analog of 1α,25-dihydroxyvitamin D ₃ selectively induces bone formation

2002 • 174 citations

Rickets with alopecia: An inborn error of vitaminD metabolism

1979 • 174 citations

1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D ₃ Active on Bone in Anephric Rats

1972 • 171 citations

The mechanisms of vitamin D toxicity

1990 • 171 citations

Circulating 25-hydroxyvitamin D in man

1974 • 170 citations

Vitamin D is not directly necessary for bone growth and mineralization

1984 • 170 citations

The Synthesis of [1,2-³H] Vitamin D₃ and the Tissue Localization of a 0.25-μg (10 IU) Dose per Rat^*

1966 • 170 citations

Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions.

1993 • 169 citations

Mechanism of Action and Metabolic Fate of Vitamin D

1967 • 168 citations

Vitamin D - Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism

1982 • 167 citations

The Vitamin D Receptor Interacts with General Transcription Factor IIB

1995 • 166 citations

Vitamin D and Growth1

1955 • 166 citations

Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene.

1994 • 164 citations

Vitamin D, glucose, insulin, and insulin sensitivity

2008 • 160 citations

Intestinal cytosol binders of 1,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3

1976 • 159 citations

Über das antirachitisch wirksame Bestrahlungsprodukt ans 7-Dehydro-cholesterin.

1936 • 159 citations

Enhancers Located within Two Introns of the Vitamin D Receptor Gene Mediate Transcriptional Autoregulation by 1,25-Dihydroxyvitamin D₃

2006 • 158 citations

Absence of Seasonal Variation in Serum Concentrations of 1,25-Dihydroxyvitamin D Despite a Rise in 25-Hydroxyvitamin D in Summer*

1981 • 158 citations

Vitamin D receptor interaction with specific DNA. Association as a 1,25-dihydroxyvitamin D3-modulated heterodimer.

1991 • 156 citations

The influence of age on bone mineral regulating hormones

1986 • 156 citations

Vitamin D deficiency and renal calcium transport in the rat.

1984 • 155 citations

Evidence for Ligand-Dependent Intramolecular Folding of the AF-2 Domain in Vitamin D Receptor-Activated Transcription and Coactivator Interaction

1997 • 154 citations

New 1α,25-Dihydroxy-19-norvitamin D₃ Compounds of High Biological Activity: Synthesis and Biological Evaluation of 2-Hydroxymethyl, 2-Methyl, and 2-Methylene Analogues

1998 • 154 citations

Further Oxidation of Hydroxycalcidiol by Calcidiol 24‐Hydroxylase

1994 • 153 citations

Response of Chick Parathyroid Glands to the Vitamin D Metabolites, 1,25-Dihydroxycholecalciferol and 24,25-Dihydroxycholecalciferol

1977 • 151 citations

Vitamin D metabolism during pregnancy and lactation in the rat.

1979 • 150 citations

The Effects of Chloroquine on Serum 1,25-Dihydroxyvitamin D and Calcium Metabolism in Sarcoidosis

1986 • 149 citations

The turnover and transport of vitamin D and of a polar metabolite with the properties of 25-hydroxycholecalciferol in human plasma

1971 • 149 citations

Tracer Experiments on the Effect of Vitamin D on the Skeletal Metabolism of Calcium and Phosphorus

1952 • 149 citations

Vitamin D Deficiency Suppresses Cell-Mediated Immunity in Vivo

1993 • 146 citations

Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man.

1984 • 146 citations

Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties

2004 • 144 citations

25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

2004 • 144 citations

A Cellular Defect in Hereditary Vitamin-D-Dependent Rickets Type II: Defective Nuclear Uptake of 1,25-Dihydroxyvitamin D in Cultured Skin Fibroblasts

1981 • 143 citations

Hormone-dependent phosphorylation of the 1,25-dihydroxyvitamin D3 receptor in mouse fibroblasts

1985 • 142 citations

SOLAR Ultraviolet Radiation AND Vitamin D

2007 • 142 citations

REVERSIBILITY OF AIR-FLOW OBSTRUCTION

1988 • 142 citations

Effective Reduction in the Serum 1,25-Dihydroxyvitamin D and Calcium Concentration in Sarcoidosis-Associated Hypercalcemia with Short-Course Chloroquine Therapy

1989 • 140 citations

On the Mechanisms for the Selective Action of Vitamin D Analogs*

1991 • 139 citations

Functional Domains of the Human Vitamin D₃Receptor Regulate Osteocalcin Gene Expression

1989 • 139 citations

Biologic effects of 1,25-dihydroxycholecalciferol (a highly active vitamin D metabolite) in acutely uremic rats

1972 • 138 citations

Safety and efficacy of oral calcitriol (1, 25 -dihydroxyvitamin D₃ ) for the treatment of psoriasis

1996 • 138 citations

Plasma 1,25-Dihydroxyvitamin D Levels in Patients Receiving Anticonvulsant Drugs

1977 • 134 citations

Studies on the mode of action of calciferol XVIII. Evidence for a specific high affinity binding protein for 1,25 dihydroxyvitamin D3 in chick kidney and pancreas

1979 • 132 citations

A Phase I trial of pulse calcitriol in patients with refractory malignancies: pulse dosing permits substantial dose escalation.

2001 • 130 citations

Rapid, Membrane-Initiated Actions of 1,25 Dihydroxyvitamin D: What Are They and What Do They Mean?

2004 • 130 citations

Target cells for 1,25 dihydroxyvitamin D3 in the pancreas

1980 • 128 citations

Pharmacokinetics of high-dose oral calcitriol: Results from a phase 1 trial of calcitriol and paclitaxel

2002 • 127 citations

Transfer of Calcium and Strontium across Biological Membranes

1961 • 127 citations

The Effect of Anticonvulsant Therapy on Serum Levels of 25-Hydroxy-Vitamin D, Calcium, and Parathyroid Hormone

1975 • 127 citations

VITAMIN-D DEFICIENCY AMONG ASIAN IMMIGRANTS TO BRITAIN

1973 • 126 citations

The Metabolism of Vitamin D₃and 25-Hydroxyvitamin D₃in Normal and Anephric Humans

1974 • 121 citations

The Preparation of H³-Vitamins D₂ and D₃ and Their Localization in the Rat^*

1963 • 121 citations

Altered divalent ion metabolism in early renal failure: Role of 1,25(OH)2D

1985 • 120 citations

Autoradiographic localization of target cells for 1α, 25-dihydroxyvitamin D3 in bones from fetal rats

1983 • 119 citations

Acute Administration of 25-Hydroxycholecalciferol in Man

1976 • 117 citations

Vitamin D: Biochemical, Chemical and Clinical Aspects related to Calcium Metabolism

1979 • 117 citations

Structure and regulation of the rat 1,25-dihydroxyvitamin D3 receptor.

1988 • 117 citations

Biological Activity of 1,25-Dihydroxyvitamin D₃in the Rat1

1973 • 116 citations

Phosphorylation of serine 208 in the human vitamin D receptor. The predominant amino acid phosphorylated by casein kinase II, in vitro, and identification as a significant phosphorylation site in intact cells.

1993 • 115 citations

Rat adipose tissue rapidly accumulates and slowly releases an orally-administered high vitamin D dose

1998 • 114 citations

Cellular and subcellular localization of 1,25-(OH)2-vitamin D3 in rat kidney: comparison with localization of parathyroid hormone and estradiol.

1980 • 114 citations

Characterization of a receptor-like protein for 1,25-dihydroxyvitamin D3 in rat skin.

1980 • 114 citations

THE DECLINE IN VITAMIN D STATUS WITH AGE

1980 • 112 citations

Reciprocal Gene Expression of Osteoclastogenesis Inhibitory Factor and Osteoclast Differentiation Factor Regulates Osteoclast Formation

1999 • 112 citations

Vitamin D3 from rat skins irradiated in vitro with ultraviolet light

1978 • 110 citations

Calcium transport and the role of vitamin D

1969 • 109 citations

Crystal Structures of the Vitamin D Nuclear Receptor Liganded with the Vitamin D Side Chain Analogues Calcipotriol and Seocalcitol, Receptor Agonists of Clinical Importance. Insights into a Structural Basis for the Switching of Calcipotriol to a Receptor Antagonist by Further Side Chain Modification

2004 • 109 citations

Rickets including osteomalacia and tetanty

1929 • 106 citations

The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element.

1994 • 105 citations

Synthesis of 1,25-Dihydroxyvitamin D in the Nephrectomized Pregnant Rat*

1978 • 105 citations

Calcium and phosphorus deficiency in rats: effects on PTH and 1,25-dihydroxyvitamin D3.

1979 • 104 citations

Vitamin D 1α-Hydroxylase Gene Mutations in Patients with 1α-Hydroxylase Deficiency

2007 • 104 citations

1,25-Dihydroxyvitamin D3 up-regulates the 1,25-dihydroxyvitamin D3 receptor in vivo.

1989 • 103 citations

Perinatal parathyroid hormone, vitamin D metabolites, and calcitonin in man

1980 • 103 citations

A Phase I trial of pulse calcitriol in patients with refractory malignancies

2001 • 102 citations

Reduced plasma concentration of 1,25-dihydroxyvitamin D in children with moderate renal insufficiency

1982 • 101 citations

Vitamin D Metabolism and Parathyroid Function in Man

1975 • 101 citations

Serum 1,25-Dihydroxyvitamin D Levels in Normal Children and in Vitamin D Disorders

1980 • 100 citations

The photobiogenesis and metabolism of vitamin D.

1978 • 100 citations

The Cytoreceptor Assay for 1,25-Dihydroxyvitamin D and Its Application to Clinical Studies*

1983 • 100 citations

Renal adenylate cyclase and the interrelationship between parathyroid hormone and vitamin D in the regulation of urinary phosphate and adenosine cyclic 3',5'-monophosphate excretion.

1976 • 100 citations

Impaired phosphorus conservation and 1,25 dihydroxyvitamin D generation during phosphorus deprivation in familial hypophosphatemic rickets.

1983 • 99 citations

Calcipotriol (MC 903): Pharmacokinetics in rats and biological activities of metabolites

1991 • 99 citations

STUDIES ON EXPERIMENTAL RICKETS

1926 • 98 citations

A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors.

1995 • 97 citations

Phosphate-independent, carrier-mediated active transport of calcium by rat intestine

1969 • 97 citations

Reduced plasma half-life of radio-labelled 25-hydroxyvitamin D₃in subjects receiving a high-fibre diet

1983 • 97 citations

Conformational change and enhanced stabilization of the vitamin D receptor by the 1,25-dihydroxyvitamin D3 analog KH1060.

1996 • 96 citations

Prevention of immunological disorders in MRL/l mice by a new synthetic analogue of vitamin D3: 22-oxa-1.ALPHA., 25-dihydroxyvitamin D3.

1990 • 96 citations

Supranormal 25-Hydroxyvitamin D and Subnormal 1,25-Dihydroxyvitamin D

1980 • 95 citations

Active Transport of Calcium by Rat Duodenum in vivo

1961 • 94 citations

Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid x receptor.

1996 • 94 citations

Expression, Purification, and Enzymatic Properties of Recombinant Human Cytochrome P450c27 (CYP27)

1997 • 93 citations

Novel Mutations in the 1α-Hydroxylase (P450c1) Gene in Three Families with Pseudovitamin D–Deficiency Rickets Resulting in Loss of Functional Enzyme Activity in Blood-Derived Macrophages

1999 • 92 citations

Effect of 1,25-Dihydroxyvitamin D3 on the Renal Handling of Pi in Thyroparathyroidectomized Rats

1977 • 91 citations

Vitamin D deficiency in obese patients and changes in circulating vitamin D metabolites following jejunoileal bypass.

1982 • 91 citations

Mutations in the 1,25-Dihydroxyvitamin D3 Receptor Identifying C-terminal Amino Acids Required for Transcriptional Activation That Are Functionally Dissociated from Hormone Binding, Heterodimeric DNA Binding, and Interaction with Basal Transcription Factor IIB, in Vitro

1997 • 91 citations

A Phase I Pharmacokinetic and Pharmacodynamic Study of Intravenous Calcitriol in Combination with Oral Gefitinib in Patients with Advanced Solid Tumors

2007 • 90 citations

Seasonal fluctuations in serum concentrations of vitamin D metabolites in normal subjects.

1981 • 90 citations

2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts

2003 • 90 citations

Biologically active forms of vitamin D3 in kidney and intestine

1964 • 89 citations

Efficacy and safety of topical calcitriol (1,25-dihydroxyvitamin D³ ) for the treatment of psoriasis

1996 • 89 citations

Contrasting Effects of Exogenous 1,25-Dihydroxyvitamin D [1,25-(OH)₂D] Versus Endogenous 1,25-(OH)₂D, Induced by Dietary Calcium Restriction, on Vitamin D Receptors

1990 • 87 citations

Placental transfer of vitamin D3 and 25-hydroxycholecalciferol in the rat.

1971 • 87 citations

Vitamin D and Its Hydroxylated Metabolites in the Rat

1978 • 87 citations

Two novel 1α-hydroxylase mutations in French-Canadians with vitamin D dependency rickets type I

1998 • 86 citations

Biological activity of a vitamin D metabolite

1967 • 86 citations

Eight cytochrome P450s catalyze vitamin D metabolism

2004 • 85 citations

Studies on the mode of action of calciferol

1977 • 85 citations

Hydroxychloroquine treatment of hypercalcemia in a patient with sarcoidosis undergoing hemodialysis

1987 • 85 citations

Über das Provitamin aus dem Sterin der Schweineschwarte.

1936 • 84 citations

Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors

1993 • 83 citations

Nuclear and cytoplasmic binding components for vitamin D metabolites

1975 • 83 citations

Metabolism of 1,25-dihydroxycholecalciferol in the rat

1972 • 82 citations

IMMUNOCYTOCHEMICAL LOCALIZATION OF VITAMIN D-DEPENDENT CALCIUM BINDING PROTEIN IN MAMMALIAN NEPHRON

1981 • 82 citations

Drug Insight: vitamin D analogs in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease

2007 • 80 citations

1,25-Dihydroxyvitamin D3 modulates phosphorylation of serine 205 in the human vitamin D receptor: site-directed mutagenesis of this residue promotes alternative phosphorylation

1994 • 78 citations

Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate.

1986 • 77 citations

Expression and Activity of Vitamin D-Metabolizing Cytochrome P450s (CYP1α and CYP24) in Human Nonsmall Cell Lung Carcinomas*

1999 • 77 citations

The Vitamin D Receptor

2007 • 77 citations

Thyrotropes in the pituitary are target cells for 1,25 dihydroxy vitamin D3

1980 • 77 citations

Pharmacokinetics and efficacy of pulse oral versus intravenous calcitriol in hemodialysis patients.

1996 • 77 citations

CYP27B1 null mice with LacZ reporter gene display no 25-hydroxyvitamin D ₃ -1α-hydroxylase promoter activity in the skin

2005 • 76 citations

Maternal-perinatal interrelationships of vitamins D metabolism in rats

1976 • 76 citations

No Enzyme Activity of 25-Hydroxyvitamin D3 1α-Hydroxylase Gene Product in Pseudovitamin D Deficiency Rickets, Including That with Mild Clinical Manifestation

1999 • 75 citations

Safety and efficacy of oral calcitriol (1, 25 -dihydroxyvitamin D₃) for the treatment of psoriasis

1996 • 75 citations

Vitamin D-dependency rickets type II: truncated vitamin D receptor in three kindreds

1993 • 74 citations

SPONTANEOUS CURE OF VITAMIN-D DEFICIENCY IN ASIANS DURING SUMMER IN BRITAIN

1974 • 74 citations

Vitamin D from Skin: Contribution to Vitamin D Status Compared with Oral Vitamin D in Normal and Anticonvulsant-Treated Subjects

1982 • 72 citations

Novel Gene Mutations in Patients with 1α-Hydroxylase Deficiency That Confer Partial Enzyme Activityin Vitro

2002 • 71 citations

Dietary Phosphorus and 1,25-Dihydroxyvitamin D Metabolism: Influence of Insulin-Like Growth Factor I*

1988 • 71 citations

The Synthesis of

2001 • 71 citations

Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro.

1992 • 69 citations

Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D₃and calcium

2003 • 69 citations

SERUM CONCENTRATIONS OF METABOLITES OF VITAMIN D IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF). CONSEQUENCES FOR THE TREATMENT WITH 1‐α‐HYDROXY‐DERIVATIVES

1981 • 69 citations

Vitamin D and bone

1978 • 68 citations

Demonstration of a lack of change in serum 1 alpha,25-dihydroxyvitamin D in response to parathyroid extract in pseudohypoparathyroidism.

1980 • 67 citations

Determinants of Intact Parathyroid Hormone and Free 1,25-Dihydroxyvitamin D Levels in Mild and Moderate Renal Failure

1992 • 65 citations

Serum calcium and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in rat kidney in vivo.

1990 • 65 citations

Role of pituitary hormones in regulating renal vitamin D metabolism in man.

1980 • 65 citations

1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine

2006 • 63 citations

Hereditary Resistance to 1,25-Dihydroxyvitamin D

1984 • 62 citations

Effect of age and dietary calcium on renal 25(OH)D metabolism, serum 1,25(OH)2D, and PTH

1984 • 62 citations

Phosphate deprivation increases serum 1,25-(OH)2-vitamin D concentrations in healthy men

1984 • 62 citations

Ketoconazole-Induced Reduction in Serum 1,25-Dihydroxyvitamin D and Total Serum Calcium in Hypercalcemic Patients*

1988 • 61 citations

Evidence that Somatomedins Mediate the Effect of Hypophosphatemia to Increase Serum 1,25-Dihydroxyvitamin D3 Levels in Rats*

1987 • 61 citations

1α,25-dihydroxyvitamin D3 a nd 19-nor-1α,25-dihydroxyvitamin 32 suppress immunoglobulin production and thymic lymphocyte proliferation in vivo

1993 • 61 citations

The Stimulation of 1,25-Dihydroxycholecalciferol Metabolism in Vitamin D-deficient Rats by 1,25-Dihydroxycholecalciferol Treatment

1973 • 61 citations

Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays.

1992 • 60 citations

Long Biological Half-life of Vitamin D3 and its Polar Metabolites in Human Serum

1969 • 59 citations

Do tissues other than the kidney produce 1,25-dihydroxyvitamin D3 in vivo? A reexamination.

1983 • 58 citations

The 25-Hydroxyvitamin D 1α-Hydroxylase

2005 • 57 citations

Ketoconazole-Induced Reduction in Serum 1,25-Dihydroxyvitamin D*

1986 • 57 citations

Pharmacokinetics of Calcitriol in Continuous Ambulatory and Cycling Peritoneal Dialysis Patients

1990 • 56 citations

Control of plasma 1,25-(OH)2-vitamin D concentrations by calcium and phosphorus in the rat: Effects of hypophysectomy

1981 • 54 citations

Studies on the site of 1,25-dihydroxyvitamin D3 synthesis in vivo.

1983 • 54 citations

Growth hormone and triiodothyronine permit an increase in plasma 1,25(OH)2D concentrations in response to dietary phosphate deprivation in hypophysectomized rats

1983 • 52 citations

Age-dependent variations in serum 1,25-dihydroxyvitamin D in childhood

1980 • 52 citations

Quantification and kinetics of 25-hydroxyvitamin D3 by isotope dilution liquid chromatography/thermospray mass spectrometry

1993 • 52 citations

Effects of age and sex on the regulation of plasma 1,25-(OH)2-D by phosphorus in the rat

1981 • 52 citations

CIBA FOUNDATION SYMPOSIUM ON BONE STRUCTURE AND METABOLISM

1958 • 51 citations

Hypercalcemia and Increases in Serum Hormone Value during Prolonged Administration of 1α,25-Dihydroxyvitamin D

1978 • 51 citations

Vitamin D and the Active Transport of Calcium by the Small Intestine

1963 • 50 citations

The Mechanism of the Action of Growth Hormone on Vitamin D Metabolism in the Rat*

1981 • 49 citations

The induction of growth-promoting and calcifying properties in a ration by exposure to ultra-violet light

1924 • 49 citations

A New Vitamin D Analog, 2MD, Restores Trabecular and Cortical Bone Mass and Strength in Ovariectomized Rats With Established Osteopenia

2005 • 49 citations

Demonstration and Characterisation of a Testicular Receptor for 1,25‐Dihydroxycholecalciferol in the Rat

1983 • 49 citations

Mapping the Domains of the Interaction of the Vitamin D Receptor and Steroid Receptor Coactivator-1

1998 • 49 citations

Mineral metabolism in chronic renal failure with special reference to serum concentrations of 1.25(OH)2D and 24.25(OH)2D.

1981 • 48 citations

The role of autoradiographic and immunocytochemical techniques in the clarification of sites of metabolism and action of vitamin D.

1981 • 48 citations

Analysis of Binding of the 1,25-Dihydroxyvitamin D3Receptor to Positive and Negative Vitamin D Response Elements

1996 • 48 citations

Cytosolic lysophospholipase in cardiac myocytes and its inhibition by L-palmitoyl carnitine

1984 • 48 citations

METABOLIC FATE OF ADMINISTERED 1,25-DIHYDROXYCHOLECALCIFEROL IN CONTROLS AND IN PATIENTS WITH HYPOPARATHYROIDISM

1976 • 47 citations

Pharmacokinetics of 1,25(OH)2D3 and 1alpha(OH)D3 in normal and uraemic men

2002 • 46 citations

Effect of declining renal function on bone density in aging women

1988 • 45 citations

An Examination of the Importance of 24-Hydroxylation to the Function of Vitamin D during Early Development*

1981 • 45 citations

Development of New Vitamin D Analogs

2005 • 44 citations

Circulating 1 alpha,25-dihydroxyvitamin D levels after a single dose of 1 alpha,25-dihydroxyvitamin D3 or 1 alpha-hydroxyvitamin D3 in normal men.

1987 • 44 citations

25-Hydroxyvitamin D3-24-hydroxylase in rat kidney mitochondria.

1983 • 43 citations

Low Dietary Calcium Reduces 25-Hydroxycholecalciferol in Plasma of Rats

1987 • 43 citations

Blood concentrations of dihydroxylated vitamin D metabolites after an oral dose.

1980 • 42 citations

Expression of the renal 25-hydroxyvitamin D-24-hydroxylase gene: regulation by dietary phosphate

1996 • 41 citations

Pharmacokinetics and biologic effects of calcitriol in normal humans.

1985 • 41 citations

Hepatic accumulation of vitamin D3 and 25-hydroxyvitamin D3☆

1976 • 40 citations

Therapeutic Potential of Vitamin D for Multiple Sclerosis

2008 • 39 citations

The transformation of a vitamin into a hormone: the vitamin D story.

1979 • 39 citations

Hyperphosphatemic Tumoral Calcinosis: Effects of Phosphate Depletion on Vitamin D Metabolism, and of Acute Hypocalcemia on Parathyroid Hormone Secretion and Action*

1983 • 38 citations

Relative contributions of diet and sunshine to the overall vitamin D status of the grazing ewe

1984 • 38 citations

Identification of the porcine intestinal accessory factor that enables DNA sequence recognition by vitamin D receptor.

1995 • 37 citations

Ketoconazole Decreases the Serum Ionized Calcium and 1,25-Dihydroxyvitamin D Levels in Tuberculosis-Associated Hypercalcemia

1993 • 37 citations

METABOLIC ACTIVITIES OF VITAMIN D IN ANIMALS

1965 • 36 citations

Metabolic clearance rate and production rate of calcitriol in uremia

1989 • 35 citations

Plasma 1,25-dihydroxyvitamin D concentrations in cords, newborns, infants, and children

1980 • 35 citations

Sites of phosphorylation and photoaffinity labeling of the 1,25-dihydroxyvitamin D3 receptor

1991 • 35 citations

New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 with conformationally restricted side chains: Evaluation of biological activity and structural determination of VDR-bound conformations

2006 • 34 citations

Absorption, distribution, and transport of vitamin D3 and 25-hydroxyvitamin D3 in the rat

1983 • 34 citations

Vitamin D Absorption, Plasma Concentration and Urinary Excretion of 25-Hydroxyvitamin D in Nephrotic Syndrome

1991 • 34 citations

2MD, a new anabolic agent for osteoporosis treatment

2006 • 34 citations

Vitamin D–Resistant Diseases

2007 • 34 citations

Vitamin D sites of action in the pituitary studied by combined autoradiography-immunohistochemistry

1987 • 34 citations

Metabolites of 1.alpha.,25-dihydroxyvitamin D3 in rat bile

1980 • 33 citations

Vitamin D Metabolism in Pregnant Rabbits: Differences between the Maternal and Fetal Response to Administration of Large Amounts of Vitamin D₃

1982 • 32 citations

[46] Determination of vitamin D and its metabolites in plasma

1980 • 31 citations

The In Vitro Production and Activity of 24, 25-Dihydroxycholecalciferol in Cartilage and Calvarium

1978 • 31 citations

25-Hydroxyvitamin D in Plasma of Cattle

1979 • 31 citations

Kinetic properties of 25-hydroxyvitamin D- and 1.25-dihydroxyvitamin D-24-hydroxylase from chick kidney

1991 • 31 citations

Vitamin D kinetics in vivo: effect of 1,25-dihydroxyvitamin D administration

1989 • 30 citations

1,25 dihydroxyvitamin d-induced inhibition of3H-25 hydroxyvitamin D production by the rachitic rat liverin vitro

1983 • 30 citations

Studies on the role of 24-hydroxylation of vitamin D in the mineralization of cartilage and bone of vitamin D-deficient rats

1981 • 30 citations

Seasonal variation in serum 25-hydroxycholecalciferol concentrations in elderly South African patients with fractures of femoral neck.

1978 • 29 citations

Conformational Studies of Human Vitamin‐D Receptor by Antipeptide Antibodies, Partial Proteolytic Digestion and Ligand Binding

1997 • 29 citations

Autoradiographic studies with 3H 1,25 dihydroxyvitamin D3 in thyroid and associated tissues of the neck region

1987 • 28 citations

1- but not 24-hydroxylation of vitamin D is required for skeletal mineralization in rats

1983 • 27 citations

Autoradiographic Localization of 1,25-Dihydroxyvitamin D&lt;sub&gt;3&lt;/sub&gt; in Rat Placenta and Yolk Sac

1983 • 27 citations

Effects of low phosphorus and low calcium diets on the production and metabolic clearance rates of 1,25-dihydroxycholecalciferol in pigs

1985 • 27 citations

Vitamin D–Dependent Rickets

1985 • 27 citations

Regulation of renal vitamin D receptor is an important determinant of 1α,25-dihydroxyvitamin D3 levels in vivo

2002 • 27 citations

Changes in vitamin-D metabolites and parathyroid hormone in plasma following cholecalciferol administration to pre- and postmenopausal women in the Netherlands in early spring and to postmenopausal women in Curaçao

1996 • 27 citations

Unilateral nephrectomy and 1,25-dihydroxyvitamin D3

1983 • 27 citations

Skin types and epidermal photosynthesis of vitamin D3

1990 • 27 citations

The Vitamin D Receptor

2005 • 26 citations

Calcipotriol cream: A review of its use in the management of psoriasis

2006 • 26 citations

Metabolism of Tritiated 25-Hydroxycholecalciferol in Chronically Uremic Children Before and After Successful Renal Homotransplantation

1973 • 25 citations

1- but not 24-hydroxylation of vitamin D is required for growth and reproduction in rats

1983 • 25 citations

Calcitriol

1994 • 24 citations

Vitamin D metabolism in Japanese quail: gonadal hormones and dietary calcium effects.

1978 • 24 citations

Role of the Liver in the Homeostasis of Calciferol Metabolism in the Dog*

1982 • 24 citations

1,25-Dihydroxyvitamin D3: Mode of action in intestine and parathyroid glands, assay in humans and isolation of its glycoside fromSolanum malacoxylon

1976 • 23 citations

The Effect of Renal Function on Changes in Circulating Concentrations of 1,25-Dihydroxycholecalciferol after An Oral Dose

1982 • 23 citations

Role of the hypophysis in the regulation of vitamin D metabolism

1981 • 23 citations

Serum levels of vitamin D3 and 25-hydroxyvitamin D3 in elderly and young adults.

1988 • 23 citations

Appearance of the rat testicular receptor for calcitriol (1,25-dihydroxyvitamin D3) during development

1985 • 23 citations

Autoradiographic studies with 3H 1,25 (OH)2 vitamin D3 and 3H 25 (OH) vitamin D3 in rat parathyroid glands

1981 • 22 citations

Pregnancy does not alter the metabolic clearance of 1,25-dihydroxyvitamin D in rats

1990 • 21 citations

Effects of Iα,25-Dihydroxyvitamin D₃ on Active Intestinal Inorganic Phosphate Absorption

1977 • 21 citations

Extra-renal 1α-Hydroxylase Activity and Human Disease

2005 • 21 citations

Effect of the administration of 1,25-dihydroxyvitamin D3 on serum levels of 25-hydroxyvitamin D in postmenopausal osteoporosis

1982 • 21 citations

1,25‐dihydroxyvitamin D₃ in teeth of rats and humans: Receptors and nuclear localization

1985 • 20 citations

Pharmacokinetics of active vitamins D3, 1 alpha-hydroxyvitamin D3 and 1 alpha, 25-dihydroxyvitamin D3 in patients on chronic hemodialysis.

1991 • 20 citations

A novel splicing defect (IVS6+1G&gt;T) in a patient with pseudovitamin D deficiency rickets

2002 • 20 citations

Effect of vitamin D metabolites on calcitriol metabolism in experimental renal failure

1989 • 19 citations

Effect of age on plasma 1,25-(OH)2 vitamin D in the rat

1982 • 19 citations

Calcium metabolism and growth in the rat on a low-phosphorus diet as affected by vitamin D and increases in calcium intake

1956 • 19 citations

The effect of vitamin D on urinary citrate in relation to calcium, phosphorus and urinary pH

1954 • 18 citations

25-Hydroxycholecalciderol dynamics in human plasma.

1972 • 18 citations

Metabolism of [1,2]3H-vitamin D3 and [26,27]3H-25-hydroxyvitamin D3 in rachitic Chicks

1970 • 17 citations

Salivary glands epithelial and myoepithelial cells are major vitamin D targets

2007 • 17 citations

Kinetic analysis of 25-hydroxyvitamin D3 metabolism in strontium-induced rickets in the chick.

1977 • 17 citations

Selective analogs of 1α,25-dihydroxyvitamin D3 for the study of specific functions of Vitamin D

2007 • 17 citations

Characterization of Vitamin D Receptor Ligands with Cell-Specific and Dissociated Activity

2006 • 16 citations

No Difference in Intestinal Strontium Absorption After an Oral or an Intravenous 1,25(OH)2D3 bolus in Normal Subjects

1999 • 16 citations

Effect of Dietary Calcium, Phosphate and Vitamin D Deprivation on the Pharmacokinetics of 1,25-Dihydroxyvitamin D₃in the Rat

1987 • 16 citations

In vivo metabolism of calcitriol in the pregnant rabbit doe.

1988 • 15 citations

Production and Metabolic Clearance Rates of 1,25-Dihydroxyvitamin D₃during Maturation in Rats:

1990 • 14 citations

Excretion of Active Metabolites of Vitamin D in Urine and Bile of the Adult Rat

1977 • 14 citations

Effect of 2-Methylene-19-nor-(20S)-1α-Hydroxy-Bishomopregnacalciferol (2MbisP), an Analog of Vitamin D, on Secondary Hyperparathyroidism

2007 • 14 citations

Circulating Iα,25-(OH)₂D During Physiological States of Calcium

1977 • 14 citations

Oral verapamil and calcium and vitamin D metabolism in rats: effect of dietary calcium

1989 • 13 citations

Effect of dietary mineral and vitamin D content and parathyroidectomy on the plasma disappearance rate of 1,25‐dihydroxy vitamin D₃ in rats

1985 • 13 citations

[The history of rickets].

1978 • 13 citations

Synthesis of calcitroic acid, a metabolite of 1.alpha.,25-dihydroxycholecalciferol

1981 • 12 citations

Ciba Foundation Symposium on Bone Structure and Metabolism.

1957 • 12 citations

The Pharmacokinetics of a Single Dose of Calcitriol Administered Subcutaneously in Continuous Ambulatory Peritoneal Dialysis Patients

1993 • 12 citations

Verapamil induces PTH resistance but increases duodenal calcium absorption in rats

1988 • 12 citations

On the regulatory importance of 1,25-dihydroxyvitamin D3 and dietary calcium on serum levels of 25-hydroxyvitamin D3 in rats

1987 • 12 citations

Reintroduction of a classic vitamin D ultraviolet source

2007 • 11 citations

Tracer kinetics and actions of oral and intraperitoneal 1,25-dihydroxyvitamin D3 administration in rats

1990 • 11 citations

Pharmacokinetics and Amounts of 25-Hydroxycholecalciferol in Sheep Affected by Osteodystrophy

1979 • 10 citations

1α,25-ジヒドロキシコレカルシフェロールの代謝産物,カルシトロン酸の合成

1981 • 10 citations

Plasma Levels of Vitamin D Metabolites in Fetal and Pregnant Ewes

1987 • 9 citations

Ethanol-Induced Artifacts in the Metabolism of 3H-Vitamin D3

1969 • 9 citations

The Vitamin D-Caicium Axis-1983

1985 • 9 citations

Usefulness and pharmacokinetics of subcutaneous calcitriol in the treatment of secondary hyperparathyroidism

1996 • 9 citations

Influence of vitamin D₃ states, phenobarbital, and diphenylhydantoin treatment on the plasma 25-hydroxyvitamin D₃ concentrations in the rat

1981 • 8 citations

Molecular Basis of the Diversity of Vitamin D Target Genes

2005 • 7 citations

Vasodilator properties of a family of bioactive atrial peptides in isolated perfused rat kidneys.

1985 • 7 citations

Mouse Models of Vitamin D Receptor Ablation

2005 • 7 citations

PLASMA KINETICS OF INTRAVENOUS CALCITRIOL IN NORMAL AND DIALYSED SUBJECTS AND ACUTE EFFECT ON SERUM nPTH LEVELS.

1988 • 6 citations

The Mode of Action of Vitamin D

2008 • 6 citations

Calcium metabolism and growth in the rat on a lowphosphorus diet as affected by vitamin D and increases in calcium intake.

1956 • 5 citations

Kinetics of serum 25-hydroxyvitamin D in patients with acute renal failure

1978 • 5 citations

Glucocorticoids and Vitamin D

2011 • 3 citations

Additional protein factors play a role in the formation of VDR/RXR complexes on vitamin D response elements

1998 • 3 citations

Glucocorticoids and Vitamin D

2005 • 3 citations

ChemInform Abstract: SYNTHESIS OF CALCITROIC ACID, A METABOLITE OF 1α,25‐DIHYDROXYCHOLECALCIFEROL

1981 • 2 citations