From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health

Vitamin D

1979 • 3,814 citations

Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

2006 • 3,773 citations

Physicians Desk Reference

1994 • 2,653 citations

High Prevalence of Vitamin D Inadequacy and Implications for Health

2006 • 2,019 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,778 citations

Hypovitaminosis D is associated with insulin resistance and β cell dysfunction

2004 • 1,601 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,556 citations

Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression

2004 • 1,528 citations

Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain

2004 • 1,323 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Vitamin D₂Is Much Less Effective than Vitamin D₃in Humans

2004 • 1,096 citations

1,25-Dihydroxyvitamin D ₃ Receptors in Human Leukocytes

1983 • 1,030 citations

Caveolae: From Cell Biology to Animal Physiology

2002 • 977 citations

Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts

2005 • 867 citations

Vitamin D Deficiency Inhibits Pancreatic Secretion of Insulin

1980 • 717 citations

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D–dependent mechanism

2007 • 654 citations

Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2

1998 • 654 citations

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

2004 • 556 citations

Vitamin D Receptor: New Assignments for an Already Busy Receptor

2006 • 555 citations

1,25-Dihydroxyvitamin D ₃ : a Novel Immunoregulatory Hormone

1984 • 536 citations

STUDIES ON EXPERIMENTAL RICKETS

1922 • 454 citations

Hypercalcemia in an Anephric Patient with Sarcoidosis: Evidence for Extrarenal Generation of 1,25-Dihydroxyvitamin D

1981 • 417 citations

The vitamin D questions: How much do you need and how should you get it?

2006 • 372 citations

Vitamin D and Placental-Decidual Function

2004 • 335 citations

The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro

2004 • 327 citations

Synthesis of 1,25-Dihydroxyvitamin D3 by Human Endothelial Cells Is Regulated by Inflammatory Cytokines

2002 • 313 citations

Action of 1,25-Dihydroxycholecalciferol, a Potent, Kidney-Produced Metabolite of Vitamin D₃, in Uremic Man

1972 • 260 citations

Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement

2006 • 254 citations

Hypocalcaemia and vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure

2007 • 253 citations

Vitamin D and type 1 diabetes mellitus: state of the art

2005 • 253 citations

Vitamin D and bone

2003 • 247 citations

HPLC Method for 25-Hydroxyvitamin D Measurement: Comparison with Contemporary Assays

2006 • 243 citations

Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse

2006 • 227 citations

13th Workshop consensus for vitamin D nutritional guidelines

2007 • 221 citations

Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

2004 • 218 citations

Vitamin D: A Cholecalciferol Metabolite Highly Active in Promoting Intestinal Calcium Transport

1971 • 211 citations

Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands

2004 • 205 citations

Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status

2007 • 188 citations

1,25 Dihydroxy-Vitamin D_3 in Normal Man and Patients with Renal Failure

1974 • 182 citations

25-Hydroxyvitamin D₃-1α-Hydroxylase Expression in Normal and Pathological Parathyroid Glands

2002 • 180 citations

Vitamin D requirements: current and future

2004 • 175 citations

Rapid modulation of osteoblast ion channel responses by 1α,25(OH) ₂ -vitamin D ₃ requires the presence of a functional vitamin D nuclear receptor

2004 • 153 citations

Biological actions of extra-renal 25-hydroxyvitamin D-1α-hydroxylase and implications for chemoprevention and treatment

2005 • 151 citations

25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

2004 • 144 citations

25-Hydroxyvitamin D₃-1α-hydroxylase Expression in Normal and Malignant Human Colon

2004 • 135 citations

Relationship of Intestinal Calcium Absorption to 1,25-Dihydroxyvitamin D [1,25(OH)₂D] Levels in YoungVersusElderly Women: Evidence for Age-Related Intestinal Resistance to 1,25(OH)₂D Action¹

2000 • 133 citations

Studies upon the mode of action of vitamin D

1937 • 132 citations

Quantification of Serum 25-Hydroxyvitamin D₂and D₃Using HPLC–Tandem Mass Spectrometry and Examination of Reference Intervals for Diagnosis of Vitamin D Deficiency

2006 • 132 citations

Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice

2007 • 127 citations

The assessment of circulating 25(OH)D and 1,25(OH)2D: Where we are and where we are going

2007 • 127 citations

Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural and Synthetic Ligands

2003 • 125 citations

Relationship of Intestinal Calcium Absorption to 1,25-Dihydroxyvitamin D [1,25(OH)2D] Levels in Young Versus Elderly Women: Evidence for Age-Related Intestinal Resistance to 1,25(OH)2D Action

2000 • 102 citations

Mechanism and Potential of the Growth-Inhibitory Actions of Vitamin D and Analogs

2007 • 102 citations

Molecular mechanisms mediating the anti-proliferative effects of Vitamin D in prostate cancer

2005 • 100 citations

STUDIES ON EXPERIMENTAL RICKETS

1926 • 98 citations

Vitamin D Metabolism

1984 • 97 citations

Failure of High-Dose Ergocalciferol to Correct Vitamin D Deficiency in Adults with Cystic Fibrosis

2005 • 97 citations

Profile of ligand specificity of the vitamin D binding protein for 1α,25-dihydroxyvitamin d3 and its analogs

1994 • 80 citations

Serum levels of vitamin D metabolites and bone remodelling in hyperthyroidism

1982 • 78 citations

Sun protection and Vitamin D: Three dimensions of obfuscation

2007 • 74 citations

Bone resorption markers in vitamin D insufficiency

2006 • 74 citations

25-Hydroxyvitamin D31α-hydroxylase expression in breast cancer and use of non-1α-hydroxylated vitamin D analogue

2005 • 70 citations

Demonstration that the Vitamin D Metabolite 1,25(OH)2-Vitamin D3 and Not 24R,25(OH)2-Vitamin D3 Is Essential for Normal Insulin Secretion in the Perfused Rat Pancreas

1985 • 67 citations

Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle

2004 • 61 citations

The 25-Hydroxyvitamin D 1α-Hydroxylase

2005 • 57 citations

Vitamin D Metabolism

2005 • 57 citations

Presence of a Truncated Form of the Vitamin D Receptor (VDR) in a Strain of VDR-Knockout Mice

2005 • 52 citations

Studies upon the mode of action of vitamin D

1937 • 49 citations

A Study of Rats on a Normal Diet Irradiated daily by the Mercury Vapour Quartz Lamp or kept in Darkness

1923 • 48 citations

Mechanisms of decreased Vitamin D 1α-hydroxylase activity in prostate cancer cells

2004 • 46 citations

Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion.

2002 • 42 citations

Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions

2005 • 42 citations

Where We are, and Where We are Going

1988 • 37 citations

Regulation of extrarenal synthesis of 1,25-dihydroxyvitamin D3––relevance for colonic cancer prevention and therapy

2003 • 31 citations

Importance of vitamin D repletion in uraemia

1999 • 29 citations

Effects of 24,25-dihydroxy-vitamin D3 on its plasma level in man

1981 • 9 citations

Reverse Phase Liquid Chromatographic Determination of Vitamins D2 and D3 in Milk

1982 • 5 citations