Pathogenic role of Fgf23 in Hyp mice

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

2000 • 1,480 citations

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

2001 • 1,403 citations

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

2004 • 1,343 citations

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

2004 • 1,286 citations

A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets

1995 • 1,077 citations

Increased Circulatory Level of Biologically Active Full-Length FGF-23 in Patients with Hypophosphatemic Rickets/Osteomalacia

2002 • 661 citations

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone

2005 • 582 citations

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice

2004 • 522 citations

Regulation of Fibroblastic Growth Factor 23 Expression but Not Degradation by PHEX

2003 • 490 citations

Transgenic Mice Expressing Fibroblast Growth Factor 23 under the Control of the α1(I) Collagen Promoter Exhibit Growth Retardation, Osteomalacia, and Disturbed Phosphate Homeostasis

2004 • 489 citations

Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23

2001 • 481 citations

FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa

2004 • 421 citations

Serum FGF23 Levels in Normal and Disordered Phosphorus Homeostasis

2003 • 350 citations

Transgenic Mice Overexpressing Human Fibroblast Growth Factor 23 (R176Q) Delineate a Putative Role for Parathyroid Hormone in Renal Phosphate Wasting Disorders

2004 • 322 citations

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.

1997 • 283 citations

The Autosomal Dominant Hypophosphatemic Rickets R176Q Mutation in Fibroblast Growth Factor 23 Resists Proteolytic Cleavage and Enhances in Vivo Biological Potency

2003 • 264 citations

FGF23 is processed by proprotein convertases but not by PHEX

2004 • 251 citations

Analysis of the Biochemical Mechanisms for the Endocrine Actions of Fibroblast Growth Factor-23

2005 • 208 citations

Pex Gene Deletions in Gy and Hyp Mice Provide Mouse Models for X-Linked Hypophosphatemia

1997 • 198 citations

cDNA Cloning of the MurinePexGene Implicated in X-Linked Hypophosphatemia and Evidence for Expression in Bone

1996 • 174 citations

Osteomalacia in Hyp Mice Is Associated with Abnormal Phex Expression and with Altered Bone Matrix Protein Expression and Deposition¹

2001 • 160 citations

Pex mRNA Is Localized in Developing Mouse Osteoblasts and Odontoblasts

1998 • 159 citations

Developmental Expression and Tissue Distribution of Phex Protein: Effect of the Hyp Mutation and Relationship to Bone Markers

2000 • 135 citations

Histological Analysis of GFP Expression in Murine Bone

2005 • 131 citations

Fibroblast Growth Factor-23 Mutants Causing Familial Tumoral Calcinosis Are Differentially Processed

2005 • 130 citations

Intrinsic mineralization defect inHyp mouse osteoblasts

1998 • 116 citations

Cloning and Sequencing of Human PEX from a Bone cDNA Library: Evidence for Its Developmental Stage-Specific Regulation in Osteoblasts

1997 • 109 citations

Evidence for a bone-kidney axis regulating phosphate homeostasis

2003 • 108 citations

Defective bone formation by hyp mouse bone cells transplanted into normal mice: Evidence in favor of an intrinsic osteoblast defect

1992 • 104 citations

Role of Matrix Extracellular Phosphoglycoprotein in the Pathogenesis of X-Linked Hypophosphatemia

2005 • 90 citations

Overexpression of Phex in Osteoblasts Fails to Rescue the Hyp Mouse Phenotype

2002 • 88 citations

Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin

2002 • 75 citations

The Neprilysin Family in Health and Disease

2006 • 68 citations

Coordinated Maturational Regulation of PHEX and Renal Phosphate Transport Inhibitory Activity: Evidence for the Pathophysiological Role of PHEX in X-Linked Hypophosphatemia

1999 • 54 citations

The Effects of Bone Marrow Transplantation on X-linked Hypophosphatemic Mice

2000 • 31 citations