Degradation of the Met Tyrosine Kinase Receptor by the Ubiquitin-Proteasome Pathway

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes.

1986 • 847 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Soluble receptors for cytokines and growth factors: generation and biological function

1994 • 766 citations

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.

1993 • 707 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor

1990 • 415 citations

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 • 409 citations

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

1992 • 327 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros.

1995 • 309 citations

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.

1995 • 304 citations

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells.

1995 • 301 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product

1993 • 281 citations

Helper-independent transformation by unintegrated Harvey sarcoma virus DNA

1978 • 277 citations

Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis

1996 • 277 citations

The met Proto-Oncogene Receptor and Lumen Formation

1992 • 246 citations

Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells

1995 • 231 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

Biosynthesis of the protein encoded by the c-met proto-oncogene.

1989 • 220 citations

The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

1994 • 215 citations

Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium.

1994 • 209 citations

Involvement of Hepatocyte Growth Factor in Kidney Development

1994 • 200 citations

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.

1992 • 173 citations

Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.

1991 • 166 citations

C-terminal truncated forms of Met, the hepatocyte growth factor receptor.

1991 • 165 citations

The Transforming Receptor Tyrosine Kinase, Axl, Is Post-translationally Regulated by Proteolytic Cleavage

1995 • 159 citations

Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.

1994 • 157 citations

The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage.

1993 • 156 citations

Hepatocyte growth factor-scatter factor (HGF-SF) and the C-met receptor

1993 • 146 citations

Degradation Process of Ligand-stimulated Platelet-derived Growth Factor β -Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway

1995 • 139 citations

Mechanism of kit ligand, phorbol ester, and calcium-induced down-regulation of c-kit receptors in mast cells

1993 • 139 citations

Roles of HGF as a pleiotropic factor in organ regeneration.

1993 • 131 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor.

1988 • 123 citations

Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells

1994 • 119 citations

Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells.

1996 • 114 citations

Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase.

1994 • 110 citations

Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.

1995 • 107 citations

A role for HGF/SF in neural induction and its expression in Hensen’s node during gastrulation

1995 • 106 citations

Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.

1993 • 102 citations

A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells.

1991 • 93 citations

Make it or break it: the role of ubiquitin-dependent proteolysis in cellular regulation

1995 • 83 citations

The role of kinase activity and the kinase insert region in ligand-induced internalization and degradation of the c-fms protein.

1991 • 75 citations

Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behaviour of epithelial cells.

1993 • 66 citations

Structural and functional domains critical for constitutive activation of the HGF-receptor (Met).

1994 • 65 citations

Ligand-Induced Polyubiquitination of Receptor Tyrosine Kinases

1995 • 58 citations

Signal transduction in c-met mediated motogenesis.

1993 • 50 citations

Evidence for non-covalent clusters of the c-met proto-oncogene product.

1992 • 48 citations

Expression of constitutively activated hepatocyte growth factor/scatter factor receptor (c-met) in B16 melanoma cells selected for enhanced liver colonization.

1995 • 42 citations

Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum.

1994 • 40 citations

Protein kinase C-dependent release of a functional whole extracellular domain of the mast cell growth factor (MGF) receptor by MGF-dependent human myeloid cells.

1994 • 20 citations

Tumor cytotoxic activity of HGF-SF.

1993 • 13 citations