Sprouty, an Intracellular Inhibitor of Ras Signaling

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

1997 • 5,415 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye

1996 • 879 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways

1998 • 745 citations

The Autosomal FLP-DFS Technique for Generating Germline Mosaics in Drosophila melanogaster

1996 • 652 citations

Chapter 24 Imaging Neuronal Subsets and Other Cell Types in Whole-Mount Drosophila Embryos and Larvae Using Antibody Probes

1994 • 608 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Increasing Complexity of the Ras Signaling Pathway

1998 • 585 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Gene disruptions using P transposable elements: an integral component of the Drosophila genome project.

1995 • 472 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells

1988 • 440 citations

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

1990 • 389 citations

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

1998 • 369 citations

Cell death in normal and rough eye mutants of Drosophila

1991 • 364 citations

The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages

1988 • 351 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway.

1993 • 320 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

1995 • 312 citations

Cell determination strategies in the Drosophila eye

1997 • 308 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype.

1990 • 267 citations

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

1995 • 251 citations

Drosophila Melanogaster: Practical Uses in Cell and Molecular Biology

1994 • 251 citations

A thousand and one roles for the Drosophila EGF receptor

1997 • 250 citations

An Autoregulatory Cascade of EGF Receptor Signaling Patterns the Drosophila Egg

1998 • 247 citations

The argos gene encodes a diffusible factor that regulates cell fate decisions in the drosophila eye

1992 • 238 citations

The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm

1996 • 232 citations

The Ras signaling pathway in Drosophila

1995 • 226 citations

Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila.

1989 • 213 citations

Multiple functions of the EGF receptor in Drosophila eye development

1998 • 210 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development

1994 • 195 citations

Protein Kinase C: Seeing two domains

1995 • 186 citations

Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis

1998 • 183 citations

DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila

1996 • 180 citations

The bride of sevenless and sevenless interaction: Internalization of a transmembrane ligand

1992 • 172 citations

Ras effectors and their role in mitogenesis and oncogenesis

1997 • 167 citations

Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration.

1994 • 156 citations

There Must Be 50 Ways to Rule the Signal: The Case of the Drosophila EGF Receptor

1997 • 134 citations

Behaviour of cells mutant for an EGFreceptorhomologue ofDrosophilain genetic mosaics

1990 • 110 citations

Similarities between trunk and spätzle, putative extracellular ligands specifying body pattern in Drosophila.

1995 • 77 citations

Chapter 9 Transformation Techniques for Drosophila Cell Lines

1994 • 77 citations

Conspiracy Theory

1998 • 74 citations

Apical cell surface expression of rat dipeptidyl peptidase IV in transfected Madin-Darby canine kidney cells

1991 • 52 citations

Control of EGF receptor activation in Drosophila

1997 • 45 citations

Association of Drosophila cysteine string proteins with membranes

1996 • 35 citations

Disabled Is a Putative Adaptor Protein That Functions during Signaling by the Sevenless Receptor Tyrosine Kinase

1998 • 28 citations

In Vivo Analysis of Argos Structure-Function

1998 • 28 citations

Chapter 17 Preparation and Analysis of Membranes and Membrane Proteins from Drosophila

1994 • 14 citations