Xenopus Neuralized Is a Ubiquitin Ligase that Interacts with XDelta1 and Regulates Notch Signaling

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Normal Table of Xenopus Laevis.

1968 • 1,185 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

1995 • 669 citations

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

2000 • 634 citations

UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS

1998 • 617 citations

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1983 • 493 citations

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

2000 • 492 citations

Maintenance of neuroepithelial progenitor cells by Delta–Notch signalling in the embryonic chick retina

1997 • 425 citations

Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing

1997 • 369 citations

Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos

1993 • 366 citations

Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of Delta

2001 • 333 citations

A New Ticket for Entry into Budding Vesicles—Ubiquitin

2001 • 321 citations

The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis

1997 • 287 citations

The function of the neurogenic genes during epithelial development in the Drosophila embryo

1992 • 248 citations

The emergence of sense organs in the wing disc of Drosophila

1991 • 237 citations

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

1993 • 222 citations

Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis

1997 • 207 citations

A two-step mechanism generates the spacing pattern of the ciliated cells in the skin of Xenopus embryos

1999 • 193 citations

The ubiquitin-proteasome system and endocytosis

1999 • 188 citations

Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila

1998 • 177 citations

Neuralized functions as an E3 ubiquitin ligase during Drosophila development

2001 • 152 citations

The intracellular deletions of DELTA and SERRATE define dominant negative forms of the Drosophila Notch ligands

1996 • 149 citations

Altered Epidermal Growth Factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions

1993 • 147 citations

The Expression of Neurogenic Loci in Imaginal Epidermal Cells of Drosophila Melanogaster

1984 • 146 citations

The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe

2000 • 122 citations

The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.

1991 • 112 citations

neuralized Functions Cell-Autonomously to Regulate a Subset of Notch-Dependent Processes during Adult Drosophila Development

2001 • 87 citations

Neuralized functions cell autonomously to regulate Drosophila sense organ development

2000 • 84 citations

Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz.

2000 • 84 citations

The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster

1997 • 83 citations

Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-α homolog Spitz

2000 • 74 citations

Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region

1998 • 70 citations

neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development

2001 • 57 citations

Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized

2001 • 57 citations

The Drosophila neuralized gene encodes a C3HC4 zinc finger.

1993 • 41 citations