Interleukin‐1β Induces Cyclooxygenase‐2 and Prostaglandin E₂ Synthesis in Human Neuroblastoma Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

CYCLOOXYGENASES 1 AND 2

1998 • 2,700 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

1993 • 1,222 citations

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 • 661 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.

1996 • 597 citations

p38 Mitogen-activated Protein Kinase Regulates Cyclooxygenase-2 mRNA Stability and Transcription in Lipopolysaccharide-treated Human Monocytes

1999 • 495 citations

Structure of the human cyclo-oxygenase-2 gene

1994 • 488 citations

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

1998 • 455 citations

Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β

1997 • 390 citations

p38 Kinase Is Activated in the Alzheimer's Disease Brain

1999 • 365 citations

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.

1997 • 288 citations

Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N -methyl- <scp>d</scp> -aspartic acid-receptors and phospholipase A ₂

1997 • 286 citations

Study of Gene Regulation by NF-κB and AP-1 in Response to Reactive Oxygen Intermediates

1997 • 284 citations

Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway

1998 • 275 citations

Involvement of NF‐κB in the regulation of cyclooxygenase‐2 protein expression in LPS‐stimulated J774 macrophages

1997 • 266 citations

17α-Estradiol Exerts Neuroprotective Effects on SK-N-SH Cells

1997 • 259 citations

Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide

1997 • 249 citations

Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease

1999 • 243 citations

Expression and Regulation of Cyclooxygenase‐2 in Rat Microglia

1997 • 241 citations

Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells

1996 • 238 citations

Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs

1999 • 237 citations

Interleukin-1β-induced Cyclooxygenase-2 Expression Requires Activation of Both c-Jun NH2-terminal Kinase and p38 MAPK Signal Pathways in Rat Renal Mesangial Cells

1998 • 232 citations

Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors

1996 • 222 citations

Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2

1999 • 220 citations

Distinct isoforms (COX‐1 and COX‐2) of cyclooxygenase: possible physiological and therapeutic implications

1996 • 208 citations

Increased Expression of Cyclooxygenases and Peroxisome Proliferator-Activated Receptor-γ in Alzheimer's Disease Brains

1999 • 205 citations

Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients

1995 • 204 citations

Cyclooxygenase‐2 Induction in Cerebral Cortex: An Intracellular Response to Synaptic Excitation

1996 • 201 citations

Cyclooxygenase‐2 is induced globally in infarcted human brain

1998 • 193 citations

Interleukin‐1β Induces Prostaglandin G/H Synthase‐2 (Cyclooxygenase‐2) in Primary Murine Astrocyte Cultures

1996 • 190 citations

p38 Mitogen-activated Protein Kinase Down-regulates Nitric Oxide and Up-regulates Prostaglandin E2 Biosynthesis Stimulated by Interleukin-1β

1997 • 181 citations

Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms

1997 • 180 citations

Maturational Regulation and Regional Induction of Cyclooxygenase-2 in Rat Brain: Implications for Alzheimer's Disease

1997 • 175 citations

Microglial interleukin-lα expression in human head injury: Correlations with neuronal and neuritic β-amyloid precursor protein expression

1994 • 169 citations

Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: A current appraisal

1996 • 158 citations

Induction of cyclo-oxygenase 2 in brains of patients with Downʼs syndrome and dementia of Alzheimer type

1997 • 152 citations

Cyclooxygenase 2 RNA message abundance, stability, and hypervariability in sporadic alzheimer neocortex

1997 • 139 citations

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease

1995 • 119 citations

Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha.

1999 • 105 citations

Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase

1999 • 103 citations

Prostaglandin E₂ Induces Interleukin‐6 Synthesis in Human Astrocytoma Cells

1997 • 98 citations

Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.

1997 • 98 citations

Lipopolysaccharide Modulates Cyclooxygenase-2 Transcriptionally and Posttranscriptionally in Human Macrophages Independently from Endogenous IL-1β and TNF-α

1999 • 91 citations

Differential cellular distribution and dynamics of Hsp70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid

1997 • 86 citations

NSAIDS inhibit the IL-1β-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2

1997 • 80 citations

Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia

1996 • 70 citations

Interleukin‐1β Uses Common and Distinct Signaling Pathways for Induction of the Interleukin‐6 and Tumor Necrosis Factor α Genes in the Human Astrocytoma Cell Line U373

1996 • 68 citations

Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death

1998 • 67 citations

Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease

1996 • 62 citations

Prostaglandins as Putative Neurotoxins in Alzheimer's Disease

1998 • 56 citations

Clinical experience with cyclooxygenase-2 inhibitors

1999 • 36 citations