p38 Mitogen-activated Protein Kinase Regulates Cyclooxygenase-2 mRNA Stability and Transcription in Lipopolysaccharide-treated Human Monocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

Transcriptional Roles of Nuclear Factor κB and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor α-Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells

1995 • 657 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

1992 • 562 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1997 • 424 citations

The Primary Structure of p38γ: A New Member of p38 Group of MAP Kinases

1996 • 393 citations

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1997 • 363 citations

Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase

1997 • 332 citations

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

1996 • 331 citations

Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.

1998 • 325 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.

1997 • 288 citations

Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue

1996 • 287 citations

Regulation of Monocyte IL-10 Synthesis by Endogenous IL-1 and TNF-α: Role of the p38 and p42/44 Mitogen-Activated Protein Kinases

1998 • 270 citations

Involvement of NF‐κB in the regulation of cyclooxygenase‐2 protein expression in LPS‐stimulated J774 macrophages

1997 • 266 citations

T Cell Proliferation in Response to Interleukins 2 and 7 Requires p38MAP Kinase Activation

1997 • 254 citations

Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide

1997 • 249 citations

Activation of Transcription Factor NF-κB and p38 Mitogen-activated Protein Kinase Is Mediated by Distinct and Separate Stress Effector Pathways

1997 • 239 citations

Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation

1996 • 235 citations

Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver

1996 • 234 citations

Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP beta promoter element.

1993 • 234 citations

Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

1997 • 226 citations

The p38‐MAPK inhibitor, SB203580, inhibits cardiac stress‐activated protein kinases/c‐Jun N‐terminal kinases (SAPKs/JNKs)

1998 • 224 citations

IκBα Degradation and Nuclear Factor-κB DNA Binding Are Insufficient for Interleukin-1β and Tumor Necrosis Factor-α-induced κB-dependent Transcription

1998 • 194 citations

Transcriptional Role of the Nuclear Factor κB Site in the Induction by Lipopolysaccharide and Suppression by Dexamethasone of Cyclooxygenase-2 in U937 Cells

1998 • 185 citations

SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases

1996 • 159 citations

Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

1993 • 123 citations

Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha.

1995 • 100 citations

Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.

1997 • 98 citations

Dissociation of Basal Turnover and Cytokine-Induced Transcript Stabilization of the Human Cyclooxygenase-2 mRNA by Mutagenesis of the 3′-Untranslated Region

1998 • 81 citations

Activation of STAT5 by Lipopolysaccharide Through Granulocyte-Macrophage Colony-Stimulating Factor Production in Human Monocytes

1998 • 57 citations

Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.

1994 • 51 citations

Synthesis of prostaglandin H synthase-2 by human alveolar macrophages in response to lipopolysaccharide is inhibited by decreased cell oxidant tone

1994 • 49 citations

Characterization of human cyclooxygenase 2 gene promoter localization of a TGF-β response element

1997 • 43 citations

Selective activation of JNK/SAPK by interleukin‐1 in rabbit liver is mediated by MKK7

1997 • 41 citations