The HIV-1 Nef Protein Acts as a Connector with Sorting Pathways in the Golgi and at the Plasma Membrane

Current protocols in molecular biology

1988 • 2,473 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Protein Sorting by Transport Vesicles

1996 • 1,168 citations

Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

1995 • 1,158 citations

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1996 • 1,041 citations

Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection

1995 • 1,008 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression

1989 • 574 citations

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

1992 • 553 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1987 • 523 citations

β-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the golgi complex, shows homology to β-adaptin

1991 • 489 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

T cell antigen receptor signal transduction

1997 • 390 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein β-adaptin

1991 • 376 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes.

1996 • 357 citations

The CD4 Determinant for Downregulation by HIV-1 Nef Directly Binds to Nef. Mapping of the Nef Binding Surface by NMR

1996 • 347 citations

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator

1995 • 309 citations

Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.

1993 • 291 citations

Cytoplasmic coat proteins involved in endosome function

1995 • 290 citations

CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor

1990 • 228 citations

Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages

1990 • 221 citations

A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic Pathway

1995 • 219 citations

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef

1995 • 191 citations

Multiple GTP-binding proteins participate in clathrin-coated vesicle-mediated endocytosis.

1993 • 188 citations

Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.

1994 • 188 citations

CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.

1993 • 186 citations

Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.

1986 • 171 citations

Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

1994 • 166 citations

Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting.

1993 • 144 citations

The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

1992 • 141 citations

Epidermal growth factor receptor is down-regulated by a 10,400 MW protein encoded by the E3 region of adenovirus

1989 • 138 citations

Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells.

1991 • 137 citations

Transient modulation and internalization of T4 antigen induced by phorbol esters.

1986 • 137 citations

Cytoplasmic localization of the HTLV-III 3′orf protein in cultured T cells

1986 • 134 citations

Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane

1990 • 131 citations

Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines

1995 • 128 citations

Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4

1991 • 120 citations

Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells

1993 • 118 citations

The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4

1993 • 114 citations

Structural features of the cytoplasmic region of CD4 required for internalization.

1990 • 111 citations

Genetic characterization of human immunodeficiency virus type 1 nef gene products translated in vitro and expressed in mammalian cells

1991 • 109 citations

A C-terminally-anchored Golgi protein is inserted into the endoplasmic reticulum and then transported to the Golgi apparatus.

1995 • 105 citations

Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells.

1989 • 102 citations

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail.

1995 • 100 citations

Myristoylation-dependent Binding of HIV-1 Nef to CD4

1994 • 86 citations

The roles of CD4 and CD8 in T cell activation.

1991 • 86 citations

CD4: Collaborator in immune recognition and HIV infection

1990 • 86 citations

NEF-CD4 Physical Interaction Sensed with the Yeast Two-Hybrid System

1996 • 82 citations

T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection.

1988 • 81 citations

Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

1995 • 80 citations

Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef

1993 • 66 citations

Disruption of the CD4-p56lck complex is required for rapid internalization of CD4.

1992 • 62 citations

Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum

1992 • 61 citations

HIV-1 Nef activity in murine T cells. CD4 modulation and positive enhancement.

1994 • 54 citations

Endocytosis of ß2 integrins by stimulated human neutrophils analyzed by flow cytometry

1993 • 43 citations

Myxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes

1995 • 39 citations

Inhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics

1996 • 33 citations

Evidence for intracellular down-regulation of the epidermal growth factor (EGF) receptor during adenovirus infection by an EGF-independent mechanism

1992 • 28 citations

CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire.

1991 • 18 citations