Epidermal growth factor receptor is down-regulated by a 10,400 MW protein encoded by the E3 region of adenovirus

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Epidermal Growth Factor

1979 • 2,964 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

1973 • 2,213 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

1981 • 699 citations

Nerve growth factor receptors on human melanoma cells in culture.

1977 • 670 citations

Alteration of Cell-Surface Proteins by Viral Transformation and by Proteolysis

1973 • 666 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens

1985 • 405 citations

Antiviral effects of recombinant tumour necrosis factor in vitro

1986 • 392 citations

The erbB gene of avian erythroblastosis virus is a member of the src gene family

1983 • 377 citations

Epithelial Wound Healing Enhanced by Transforming Growth Factor-α and Vaccinia Growth Factor

1987 • 368 citations

Induction of transforming growth factor-α in activated human alveolar macrophages

1988 • 359 citations

A monoclonal antibody to the human epidermal growth factor receptor

1982 • 342 citations

The role of cachectin/TNF in endotoxic shock and cachexia

1988 • 335 citations

Establishment of a continuously growing cell line from primary carcinoma of the liver.

1976 • 335 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance

1985 • 322 citations

Epidermal growth factor-dependent phosphorylation of lipocortin

1986 • 303 citations

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

1984 • 295 citations

A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor

1988 • 251 citations

Use of Nondefective Adenovirus-Simian Virus 40 Hybrids for Mapping the Simian Virus 40 Genome

1973 • 243 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Deletion of the vaccinia virus growth factor gene reduces virus virulence

1988 • 238 citations

Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells.

1982 • 232 citations

Isolation of deletion and substitution mutants of adenovirus type 5

1978 • 230 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

"E3/19K" protein of adenovirus type 2 inhibits lysis of cytolytic T lymphocytes by blocking cell-surface expression of histocompatibility class I antigens.

1987 • 215 citations

A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum

1987 • 202 citations

Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors.

1984 • 201 citations

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

1985 • 199 citations

Cis-acting induction of adenovirus transcription

1983 • 180 citations

Nucleotide sequence of the EcoRI E fragment of adenovirus 2 genome

1981 • 179 citations

Biosynthesis of the epidermal growth factor receptor in A431 cells.

1984 • 156 citations

Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line.

1978 • 151 citations

SOMATIC CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SV40-TRANSFORMED HUMAN CELLS

1974 • 135 citations

Internalization of functional epidermal growth factor:receptor/kinase complexes in A-431 cells.

1985 • 128 citations

The p35p36 substrates of protein-tyrosine kinases as inhibitors of phospholipase A2

1986 • 128 citations

Biological effects of recombinant human tumor necrosis factor and its novel muteins on tumor and normal cell lines.

1987 • 124 citations

DNA sequence of the early E3 transcription unit of adenovirus 5

1985 • 116 citations

The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.

1987 • 115 citations

Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence.

1980 • 98 citations

[36] Human adenoviruses: Growth, purification, and transfection assay

1979 • 96 citations

Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase.

1985 • 94 citations

Enhanced expression of adenovirus transforming proteins

1982 • 94 citations

Nucleotide sequence of the EcoR1 D fragment of adenovirus 2 genome

1980 • 84 citations

Deletion mutants of adenovirus 2: Isolation and initial characterization of virus carrying mutations near the right end of the viral genome

1981 • 83 citations

Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor.

1988 • 83 citations

An N-terminal region of adenovirus E1a essential for cell transformation and induction of an epithelial cell growth factor.

1988 • 68 citations

Mapping a new gene that encodes an 11,600-molecular-weight protein in the E3 transcription unit of adenovirus 2

1984 • 68 citations

Evidence that AGAUA and CCAGA initiate translation in the same mRNA in region E3 of adenovirus

1986 • 61 citations

The 19-kDa glycoprotein coded by region E3 of adenovirus. Purification, characterization, and structural analysis.

1985 • 59 citations

Adenovirus E1A 12S protein induces DNA synthesis and proliferation in primary epithelial cells in both the presence and absence of serum

1987 • 59 citations

Identification and gene mapping of a 14,700-molecular-weight protein encoded by region E3 of group C adenoviruses

1988 • 57 citations

Growth factor receptors

1989 • 52 citations

Biosynthesis of the epidermal growth factor receptor in human epidermoid carcinoma-derived A431 cells.

1984 • 51 citations

Competition between splicing and polyadenylation reactions determines which adenovirus region E3 mRNAs are synthesized.

1988 • 42 citations

Genetic analysis of mRNA synthesis in adenovirus region E3 at different stages of productive infection by RNA-processing mutants

1986 • 41 citations

Different forms of the epidermal growth factor receptor kinase have different autophosphorylation sites

1985 • 39 citations

An adenovirus mRNA which encodes a 14,700-Mr protein that maps to the last open reading frame of region E3 is expressed during infection

1988 • 28 citations

Growth factor(s) produced during infection with an adenovirus variant stimulates proliferation of nonestablished epithelial cells.

1987 • 28 citations

Biosynthesis and glycosylation of the epidermal growth factor receptor in human tumor-derived cell lines A431 and Hep 3B.

1986 • 16 citations

Structure and reversion of an adenovirus type 2 mutant containing a duplication of the left end of the genome at the right end

1983 • 11 citations