Molecular effects of paclitaxel: Myths and reality (a critical review)

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Taxol stabilizes microtubules in mouse fibroblast cells.

1980 • 1,942 citations

Paclitaxel (Taxol)

1995 • 1,747 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

1997 • 1,177 citations

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.

1993 • 1,086 citations

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

1997 • 872 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

1996 • 777 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Mechanism of action of taxol

1992 • 730 citations

Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization

1997 • 668 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

1998 • 614 citations

Bcl2 is the guardian of microtubule integrity.

1997 • 599 citations

Cell Growth & Differentiation

1992 • 558 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

Mechanisms of Taxol-induced cell death are concentration dependent.

1998 • 387 citations

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

1997 • 387 citations

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

1996 • 376 citations

Structure of tubulin at 6.5 Å and location of the taxol-binding site

1995 • 369 citations

Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase

1998 • 367 citations

Overexpression of ErbB2 Blocks Taxol-Induced Apoptosis by Upregulation of p21Cip1, which Inhibits p34Cdc2 Kinase

1998 • 354 citations

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1998 • 353 citations

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients.

1993 • 311 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Shared Actions of Endotoxin and Taxol on TNF Receptors and TNF release

1990 • 288 citations

Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway

1995 • 281 citations

Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells.

1993 • 273 citations

Activation of the Protein Kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

1998 • 264 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Mitotic Phosphorylation of Bcl-2 during Normal Cell Cycle Progression and Taxol-induced Growth Arrest

1998 • 231 citations

Coupling cell division and cell death to microtubule dynamics

1997 • 228 citations

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

1996 • 217 citations

Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase.

1994 • 200 citations

Activation of p34cdc2 coincident with taxol-induced apoptosis.

1994 • 192 citations

Cytotoxicity of the anticancer agents cisplatin and taxol during cell proliferation and the cell cycle

1994 • 192 citations

Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis

1997 • 191 citations

Control of Microtubule Dynamics by Oncoprotein 18: Dissection of the Regulatory Role of Multisite Phosphorylation during Mitosis

1997 • 189 citations

Taxol induction of p21WAF1 and p53 requires c-raf-1.

1995 • 187 citations

Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages.

1992 • 180 citations

p53-independent apoptosis induced by paclitaxel through an indirect mechanism

1997 • 173 citations

Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.

1993 • 168 citations

Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells.

1998 • 167 citations

Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids.

1997 • 165 citations

Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.

1994 • 164 citations

Bcl-xL is phosphorylated in malignant cells following microtubule disruption.

1998 • 160 citations

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells

1998 • 154 citations

p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel.

1997 • 148 citations

Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation.

1990 • 144 citations

The Microtubule-destabilizing Activity of Metablastin (p19) Is Controlled by Phosphorylation

1997 • 140 citations

Ability of the c- mos Product to Associate with and Phosphorylate Tubulin

1991 • 132 citations

Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis

1998 • 131 citations

High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.

1994 • 128 citations

Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function

1992 • 128 citations

Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.

1995 • 120 citations

Synergy between the Mos/Mitogen-Activated Protein Kinase Pathway and Loss of p53 Function in Transformation and Chromosome Instability

1997 • 119 citations

Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue.

1992 • 118 citations

"Loop" domain is necessary for taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis.

1998 • 116 citations

Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells.

1997 • 114 citations

Mitogen‐activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34^cdc2

1992 • 104 citations

Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase.

1993 • 104 citations

Cellular Sites of RNA Synthesis

1964 • 103 citations

Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells.

1996 • 96 citations

Accumulation of cyclin B1, activation of cyclin B1-dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol

1998 • 93 citations

Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line

1997 • 91 citations

Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-alpha gene expression and cytotoxicity.

1994 • 91 citations

Identification of Tumor-Specific Paclitaxel (Taxol)-Responsive Regulatory Elements in the Interleukin-8 Promoter

1997 • 90 citations

Transient stimulation of the c-Jun-NH2-terminal kinase/activator protein 1 pathway and inhibition of extracellular signal-regulated kinase are early effects in paclitaxel-mediated apoptosis in human B lymphoblasts.

1998 • 90 citations

Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer.

1996 • 88 citations

Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.

1998 • 86 citations

Ovarian cancer cisplatin-resistant cell lines: Multiple changes including collateral sensitivity to Taxol

1998 • 84 citations

Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein.

1998 • 81 citations

Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells

1999 • 72 citations

p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma

1996 • 70 citations

Acute overexpression of wt p53 facilitates anticancer drug-induced death of cancer and normal cells

1998 • 68 citations

Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids

1997 • 67 citations

Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation.

1995 • 60 citations

Combinations of pacliataxel and vinblastine and their effects on tublin polymerization and cellular cytotoxicity: Characterization of a synergistic schedule

1998 • 57 citations

Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells

1998 • 57 citations

Protein Kinase Cδ-dependent Induction of Manganese Superoxide Dismutase Gene Expression by Microtubule-active Anticancer Drugs

1998 • 54 citations

Taxol induces tyrosine phosphorylation of SHC and its association with GRB2 in murine raw 264.7 cells

1997 • 50 citations

Update on the Antitumor Activity of Paclitaxel in Clinical Trials

1994 • 50 citations

Raf-1 Is Activated during Mitosis

1995 • 47 citations

Characterization of Raf-1 Activation in Mitosis

1999 • 45 citations

Paclitaxel-induced apoptosis is associated with expression and activation of c-Mos gene product in human ovarian carcinoma SKOV3 cells.

1998 • 42 citations

Mitotic Raf-1 Is Stimulated Independently of Ras and Is Active in the Cytoplasm

1998 • 42 citations

Protein tyrosine phosphatase 1B undergoes mitosis-specific phosphorylation on serine.

1993 • 36 citations

Cell cycle-dependent phosphorylation of the 77 kDa echinoderm microtubule-associated protein (EMAP) in vivo and association with the p34cdc2 kinase

1996 • 28 citations

Activation of Mil/Raf protein kinases in mitotic cells.

1996 • 20 citations

The study of cell-death proteins in the outer mitochondrial membrane by chemical cross-linking

1997 • 12 citations

Further characterization of the c-mos transcript and its cell cycle specific expression in NIH3T3 cells.

1996 • 7 citations

Deleted Work

1955 • 0 citations