Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Fas Death Factor

1995 • 4,070 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Apoptosis and disease

1993 • 684 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Bcl2 is the guardian of microtubule integrity.

1997 • 599 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1997 • 437 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Taxol-induced polymerization of purified tubulin. Mechanism of action.

1981 • 407 citations

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

1997 • 387 citations

Angiotensin Type 2 Receptor Dephosphorylates Bcl-2 by Activating Mitogen-activated Protein Kinase Phosphatase-1 and Induces Apoptosis

1997 • 301 citations

Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.

1990 • 281 citations

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.

1994 • 222 citations

Activation of p34cdc2 coincident with taxol-induced apoptosis.

1994 • 192 citations

Paradoxical inhibition of solid tumor cell growth by bcl2.

1994 • 190 citations

Activation of c-Jun N-terminal Kinase Antagonizes an Anti-apoptotic Action of Bcl-2

1997 • 132 citations

High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.

1994 • 128 citations

Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate‐kinase I in a myeloid leukemia cell line

1991 • 120 citations

Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.

1991 • 108 citations

Molecular mechanisms of drug resistance in tumours

1995 • 81 citations

Microinjected Catalytic Subunit of cAMP-Dependent Protein Kinase Induces Apoptosis in Myeloid Leukemia (IPC-81) Cells

1993 • 69 citations

Vinca Site Agents Induce Structural Changes in Tubulin Different from and Antagonistic to Changes Induced by Colchicine Site Agents

1995 • 56 citations

Synergistic inhibition of growth and induction of apoptosis by 8-chloro-cAMP and paclitaxel or cisplatin in human cancer cells.

1997 • 44 citations

Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells.

1995 • 44 citations

Association of type II cAMP-dependent protein kinase with p34cdc2 protein kinase in human fibroblasts.

1991 • 36 citations

Antisense—Protein Kinase A: A Single-Gene-Based Therapeutic Approach

1997 • 36 citations

Synergistic effects of 8-chlorocyclic-AMP and retinoic acid on induction of apoptosis in Ewing's sarcoma CHP-100 cells.

1998 • 23 citations