p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Promotion of microtubule assembly in vitro by taxol

1979 • 3,521 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Effects of Concomitant Cisplatin and Radiotherapy on Inoperable Non-Small-Cell Lung Cancer

1992 • 1,287 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

THE IMPACT OF NATIONAL CANCER ACT

1991 • 809 citations

p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias

1995 • 749 citations

Phase II Trial of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer

1991 • 730 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Taxol binds to polymerized tubulin in vitro

1981 • 618 citations

p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies

1994 • 585 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

1987 • 472 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

Phase II Study of Taxol in Patients With Untreated Advanced Non-Small-Cell Lung Cancer

1993 • 441 citations

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

1992 • 384 citations

Phase II Study of Taxol, Merbarone, and Piroxantrone in Stage IV Non-Small-Cell Lung Cancer: The Eastern Cooperative Oncology Group Results

1993 • 346 citations

Taxol: A novel radiation sensitizer

1992 • 319 citations

Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer.

1995 • 296 citations

p53 in hematologic malignancies

1994 • 269 citations

In Vitro Studies of Taxol as a Radiation Sensitizer in Human Tumor Cells

1994 • 268 citations

Implications of the p53 tumor-suppressor gene in clinical oncology.

1995 • 258 citations

Investigation of taxol as a potential radiation sensitizer

1993 • 214 citations

p53 in hematologic malignancies

1994 • 206 citations

Taxol induction of p21WAF1 and p53 requires c-raf-1.

1995 • 187 citations

Phase I study of taxol and granulocyte colony-stimulating factor in patients with refractory ovarian cancer.

1992 • 181 citations

Phase III trial of thoracic irradiation with or without cisplatin for locally advanced unresectable non-small-cell lung cancer: a Hoosier Oncology Group protocol.

1995 • 147 citations

The biology of lung cancer.

1993 • 143 citations

p53 Alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes

1994 • 133 citations

Phase I trial of outpatient weekly paclitaxel and concurrent radiation therapy for advanced non-small-cell lung cancer.

1994 • 132 citations

Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases.

1995 • 83 citations

Phase I study of taxol using a 5-day intermittent schedule.

1986 • 68 citations

Paclitaxel as a radiation sensitizer in non-small cell lung cancer

1995 • 50 citations

Daily low-dose cisplatin plus concurrent high-dose thoracic irradiation in locally advanced unresectable non-small-cell lung cancer: results of a phase II Southwest Oncology Group study.

1994 • 41 citations

p53: from molecular mechanisms to prognosis in cancer.

1995 • 38 citations

Single-agent paclitaxel and paclitaxel plus ifosfamide in the treatment of head and neck cancer.

1995 • 28 citations