Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

Interleukin-17 Family Members and Inflammation

2004 • 2,340 citations

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

2003 • 1,280 citations

Interleukin-17 family and IL-17 receptors

2003 • 905 citations

Understanding the IL-23–IL-17 immune pathway

2005 • 759 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

IL-2, Regulatory T Cells, and Tolerance

2004 • 566 citations

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

2003 • 488 citations

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice

2003 • 470 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo

2005 • 292 citations

Design of effective immunotherapy for human autoimmunity

2005 • 276 citations

Interleukin-17: a mediator of inflammatory responses

2004 • 252 citations

Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice.

1998 • 234 citations

Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ

2004 • 209 citations

Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

1998 • 188 citations

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

1995 • 172 citations

Pathophysiology of acute graft‐versus‐host disease

2003 • 153 citations

Anti-TNF therapy: Where have we got to in 2005?

2005 • 94 citations

Unique role of CD4⁺CD62L⁺regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice

2004 • 92 citations

TGF-β, a 'double agent' in the immune pathology war

2006 • 84 citations

The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases.

2002 • 66 citations

Functional and Molecular Comparison of Anergic and Regulatory T Lymphocytes

2006 • 64 citations