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Therapeutic Use of Cytokines to Modulate Phagocyte Function for the Treatment of Infectious Diseases: Current Status of Granulocyte Colony‐Stimulating Factor, Granulocyte‐Macrophage Colony‐Stimulating Factor, Macrophage Colony‐Stimulating Factor, and Interferon‐γ

Data up to Jan 2025

Published2002
Citations146
References184

Total Citations Per Year

Abstract

References (184)

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Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay

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Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-alpha.

1992 • 251 citations

The Human Gene Encoding GM-CSF Is at 5q21-q32, the Chromosome Region Deleted in the 5q - Anomaly

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1995 • 235 citations

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1988 • 228 citations

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1990 • 227 citations

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1994 • 211 citations

A Randomized Controlled Trial of Filgrastim as an Adjunct to Antibiotics for Treatment of Hospitalized Patients with Community‐Acquired Pneumonia

1998 • 200 citations

Phase I/II trial of neutrophil transfusions from donors stimulated with G-CSF and dexamethasone for treatment of patients with infections in hematopoietic stem cell transplantation

2000 • 198 citations

Filgrastim in patients with chemotherapy-induced febrile neutropenia: A double-blind, placebo-controlled trial

1995 • 197 citations

Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells

1986 • 195 citations

Allogeneic blood stem cell transplantation: considerations for donors

1997 • 192 citations

Review: Nomenclature and Biologic Significance of Cytokines Involved in Inflammation and the Host Immune Response

1995 • 189 citations

Recombinant human TNF alpha stimulates production of granulocyte colony- stimulating factor

1987 • 189 citations

GM-CSF–deficient mice are susceptible to pulmonary group B streptococcal infection

1999 • 186 citations

Granulocyte Colony-Stimulating Factor in the Treatment of High-Risk Febrile Neutropenia: a Multicenter Randomized Trial

2001 • 181 citations

Prevention of corticosteroid-induced suppression of human polymorphonuclear leukocyte-induced damage of Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon

1993 • 181 citations

Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells.

1997 • 180 citations

Endogenous haemopoietic growth factors in neutropenia and infection

1994 • 178 citations

The Bone Marrow in AIDS: A Histologic, Hematologic, and Microbiologic Study

1985 • 173 citations

Interferon- and Tumor Necrosis Factor- Protect Mice from Invasive Aspergillosis

1995 • 170 citations

Impairment of Neutrophil Bactericidal Capacity in Patients with AIDS

1988 • 169 citations

Clinical toxicity and laboratory effects of granulocyte‐colony‐ stimulating factor (filgrastim) mobilization and blood stem cell apheresis from normal donors, and analysis of charges for the procedures

1996 • 169 citations

Mice Lacking Both Granulocyte Colony-Stimulating Factor (CSF) and Granulocyte-Macrophage CSF Have Impaired Reproductive Capacity, Perturbed Neonatal Granulopoiesis, Lung Disease, Amyloidosis, and Reduced Long-Term Survival

1997 • 161 citations

Human immunodeficiency virus infection of bone marrow endothelium reduces induction of stromal hematopoietic growth factors [see comments]

1996 • 158 citations

Phase I trial of recombinant human macrophage colony-stimulating factor in patients with invasive fungal infections

1991 • 156 citations

Recombinant Interferon- Enhances Resistance to Acute Disseminated Candida albicans Infection in Mice

1993 • 151 citations

Granulocyte-Macrophage Colony-Stimulating Factor in the Innate Immune Response to Pneumocystis carinii Pneumonia in Mice

2000 • 149 citations

Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome.

1996 • 148 citations

Granulocyte Colony‐Stimulating Factor and Granulocyte‐Macrophage Colony‐Stimulating Factor: Comparisons and Potential for Use in the Treatment of Infections in Nonneutropenic Patients

1999 • 140 citations

Severe chronic neutropenia: pathophysiology and therapy.

1997 • 135 citations

Granulocyte Colony‐Stimulating Factor Administered In Vivo Augments Neutrophil‐Mediated Activity against Opportunistic Fungal Pathogens

1997 • 134 citations

Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine

1991 • 133 citations

Improving Treatment of Chemotherapy-Induced Neutropenic Fever by Administration of Colony-Stimulating Factors

1995 • 131 citations

A comparative trial of granulocyte‐colony‐stimulating factor and dexamethasone, separately and in combination, for the mobilization of neutrophils in the peripheral blood of normal volunteers

1997 • 127 citations

Increased serum levels of granulocyte colony-stimulating factor in patients with severe congenital neutropenia

1991 • 127 citations

Neutrophil transfusions: kinetics and functions of neutrophils mobilized with granulocyte‐colony‐stimulating factor and dexamethasone

1998 • 126 citations

Interferon-γ in the Management of Infectious Diseases

1995 • 124 citations

Spleen enlargement in healthy donors during G–CSF mobilization of PBPCs

2001 • 123 citations

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1989 • 122 citations

Long-term follow-up of patients with invasive fungal disease who received adjunctive therapy with recombinant human macrophage colony- stimulating factor

1993 • 121 citations

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1997 • 117 citations

Impairment of neutrophil chemotactic and bactericidal function in children infected with human immunodeficiency virus type 1 and partial reversal after in vitro exposure to granulocyte-macrophage colony-stimulating factor

1990 • 116 citations

Recombinant Granulocyte Colony-Stimulating Factor (rG-CSF)

1991 • 115 citations

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1995 • 114 citations

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1989 • 106 citations

Neutropenia, Neutrophil Dysfunction, and Bacterial Infection in Patients with Human Immunodeficiency Virus Disease: The Role of Granulocyte Colony-Stimulating Factor

2000 • 105 citations

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2001 • 104 citations

Polymorphonuclear neutrophils from human immunodeficiency virus- infected patients show enhanced activation, diminished fMLP-induced L- selectin shedding, and an impaired oxidative burst after cytokine priming

1994 • 104 citations

Randomized placebo-controlled trial of granulocyte-macrophage colony-stimulating factor in patients with chemotherapy-related febrile neutropenia.

1996 • 102 citations

Randomized comparison between antibiotics alone and antibiotics plus granulocyte-macrophage colony-stimulating factor (Escherichia coli-derived) in cancer patients with fever and neutropenia

1996 • 101 citations

Hematologic Abnormalities in AIDS

1991 • 100 citations

Recombinant human granulocyte-macrophage colony-stimulating factor in the treatment of febrile neutropenia

1994 • 99 citations

Filgrastim prevents severe neutropenia and reduces infective morbidity in patients with advanced HIV infection

1998 • 96 citations

Defective interleukin-12/interferon-γ pathway in patients with hyperimmunoglobulinemia E syndrome

2000 • 96 citations

Effects of Macrophage Colony-Stimulating Factor on Antifungal Activity of Mononuclear Phagocytes against Aspergillus fumigatus

1995 • 95 citations

Macrophage colony-stimulating factor in murine candidiasis: serum and tissue levels during infection and protective effect of exogenous administration

1991 • 95 citations

Clinical and Immunologic Aspects of the Hyperimmunoglobulin E Syndrome

1988 • 93 citations

TREATMENT OF REFRACTORY DISSEMINATED NONTUBERCULOUS MYCOBACTERIAL INFECTION WITH INTERFERON GAMMA

1994 • 90 citations

Function and Signal Transduction Mediated by the Interleukin 3 Receptor System in Hematopoiesis

1996 • 87 citations

Administration of G–CSF plus dexamethasone producesgreater granulocyte concentrate yields while causing nomore donor toxicity than G–CSF alone

2001 • 86 citations

Changes in Granulocyte Colony-Stimulating Factor Concentration in Patients with Trauma and Sepsis

1996 • 86 citations

Depressed Neutrophil Superoxide Production in Human Immunodeficiency Virus Infection

1993 • 85 citations

Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization

1994 • 84 citations

Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers

1998 • 83 citations

Recombinant Murine Granulocyte-Macrophage Colony-Stimulating Factor Augments Neutrophil Recovery and Enhances Resistance to Infections in Myelosuppressed Mice

1991 • 81 citations

G-CSF during Escherichia coli versus Staphylococcus aureus Pneumonia in Rats Has Fundamentally Different and Opposite Effects

1999 • 81 citations

Role of Granulocyte Colony-Stimulating Factor in the Immune Response to Acute Bacterial Infection in the Nonneutropenic Host: An Overview

1994 • 80 citations

A Randomized Controlled Trial of Filgrastim for the Treatment of Hospitalized Patients with Multilobar Pneumonia

2000 • 80 citations

Differential regulation of proinflammatory and hematopoietic cytokines in human macrophages after infection with human immunodeficiency virus

1996 • 75 citations

Blood counts in healthy donors 1 year after the collection of granulocyte-colony-stimulating factor-mobilized progenitor cells and the results of a second mobilization and collection

1997 • 73 citations

The Ability of Recombinant Murine Granulocyte-Macrophage Colony-Stimulating Factor to Protect Neonatal Rats from Septic Death Due to Staphylococcus aureus

1990 • 72 citations

In vivo hematologic effects of recombinant human macrophage colony- stimulating factor

1990 • 72 citations

Neutropenia and Bacterial Infection in Acquired Immunodeficiency Syndrome

1995 • 72 citations

Safety of long-term administration of granulocyte colony-stimulating factor for severe chronic neutropenia

1997 • 72 citations

Endogenous macrophage CSF production is associated with viral replication in HIV-1-infected human monocyte-derived macrophages.

1995 • 66 citations

The medical course of cancer patients with fever and neutropenia. Clinical identification of a low-risk subgroup at presentation

1988 • 66 citations

Granulocyte‐Macrophage Colony‐Stimulating Factor Augments Phagocytosis ofMycobacterium aviumComplex by Human Immunodeficiency Virus Type 1–Infected Monocytes/Macrophages In Vitro and In Vivo

2000 • 64 citations

Safety and Effectiveness of Long-Term Interferon Gamma Therapy in Patients with Chronic Granulomatous Disease

1995 • 63 citations

In Vivo Activity Of Interferon- In Combination With Amphotericin B In The Treatment Of Experimental Cryptococcosis

1994 • 60 citations

Recombinant Murine Granulocyte Colony‐Stimulating Factor Protects against Acute DisseminatedCandida albicansInfection in Nonneutropenic Mice

1998 • 57 citations

Use of Macrophage Colony‐Stimulating Factor in the Treatment of Fungal Infections

1998 • 57 citations

Aerosolized interferon gamma for Mycobacterium avium-complex lung disease.

1995 • 55 citations

Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis.

1994 • 54 citations

Cytokine therapy of mycobacterial infections.

2000 • 54 citations

Interstitial pneumonia in patients receiving granulocyte colony-stimulating factor during chemotherapy: survey in Japan 1991-96

1997 • 52 citations

Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on the bactericidal functions of neutrophils

1997 • 52 citations

Granulocyte colony-stimulating factor worsens the outcome of experimental Klebsiella pneumoniae pneumonia through direct interaction with the bacteria

1998 • 51 citations

Efficacy of recombinant human granulocyte colony-stimulating factor on neutropenia in patients with AIDS

1990 • 50 citations

Granulocyte-macrophage colony-stimulating factor inhibits HIV-1 replication in monocyte-derived macrophages

2000 • 50 citations

Role of granulocyte-macrophage colony-stimulating factor as adjuvant treatment in neutropenic patients with bacterial and fungal infection

1994 • 48 citations

Effects of granulocyte–colony‐stimulating factor on potential normal granulocyte donors

1999 • 47 citations

Macrophage function activating cytokines: potential clinical application

1993 • 47 citations

Potential Role of Colony-Stimulating Factors in the Prevention and Treatment of Infectious Diseases

1994 • 46 citations

Filgrastim to treat neutropenia and support myelosuppressive medication dosing in HIV infection

1996 • 45 citations

Granulocyte Colony-Stimulating Factor and Antibiotics in the Prophylaxis of a Murine Model of Polymicrobial Peritonitis and Sepsis

1998 • 45 citations

Effects of Granulocyte Colony Stimulating Factor in a Nonneutropenic Rodent Model ofEscherichia coliPeritonitis

1996 • 45 citations

Immunotherapy of mycobacterial infections

2001 • 45 citations

Blood stem cell procurement: donor safety issues.

1998 • 44 citations

Interferon- in the Management of Chronic Granulomatous Disease

1991 • 44 citations

Effect of granulocyte-macrophage colony-stimulating factor on sepsis- induced organ injury in rats

1994 • 42 citations

Antifungal Activity of Recombinant Human Macrophage Colony-Stimulating Factor in Models of Acute and Chronic Candidiasis in the Rat

1994 • 41 citations

Human Immunodeficiency Virus Disease-Related Neutropenia and the Risk of Hospitalization for Bacterial Infection

1997 • 41 citations

Individual Cell Analysis of the Cytokine Repertoire in Human Immunodeficiency Virus-1–Infected Monocytes/Macrophages by a Combination of Immunocytochemistry and In Situ Hybridization

1998 • 39 citations

Macrophage Colony-Stimulating Factor Antagonists Inhibit Replication of HIV-1 in Human Macrophages

2000 • 39 citations

Combined corticosteroid/granulocyte colony-stimulating factor (G-CSF) therapy in the treatment of severe congenital neutropenia unresponsive to G-CSF

2000 • 39 citations

Hematologic Effects of AIDS Therapies

1991 • 38 citations

Immunomodulatory approaches to augment phagocyte-mediated host defense for treatment of infectious diseases

2001 • 37 citations

Interactions of phagocytic cells with Candida and other opportunistic fungi.

1993 • 36 citations

A randomized controlled phase III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia

1993 • 36 citations

Neutropenia Is Associated With Bacteremia in Patients Infected With the Human Immunodeficiency Virus

1996 • 36 citations

Combination treatment with azidothymidine and granulocyte colony-stimulating factor in children with human immunodeficiency virus infection

1992 • 35 citations

Effect of granulocyte-macrophage colony-stimulating factor on candidacidal activity of neutrophils, monocytes or monocyte-derived macrophages and synergy with fluconazole

1998 • 35 citations

Hematopoietic growth factors: biology and clinical application.

1990 • 34 citations

Granulocyte Colony‐Stimulating Factor Increases CD4+T Cell Counts of Human Immunodeficiency Virus–Infected Patients Receiving Stable, Highly Active Antiretroviral Therapy: Results from a Randomized, Placebo‐Controlled Trial

2000 • 33 citations

Use of Cytokines in Human Immunodeficiency Virus-Infected Patients: Colony-Stimulating Factors, Erythropoietin, and Interleukin-2

2001 • 30 citations

Clinical Significance of Neutropenia in Patients With Human Immunodeficiency Virus Infection

1991 • 29 citations

Role of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the treatment of patients with HIV infection

1997 • 29 citations

Preclinical and clinical evaluation of recombinant human macrophage colony-stimulating factor (rhM-CSF)

1990 • 29 citations

Collection of two peripheral blood stem cell concentrates from healthy donors

1999 • 28 citations

An Examination of Ethical Issues Raised in the Pretreatment of Normal Volunteer Granulocyte Donors With Granulocyte Colony-Stimulating Factor

1999 • 28 citations

Therapeutic Efficacy of Human Macrophage Colony-Stimulating Factor, Used Alone and in Combination with Antifungal Agents, in Mice with SystemicCandida albicansInfection

2000 • 28 citations

Neutropenia and bacterial infection in acquired immunodeficiency syndrome

1995 • 27 citations

Prediction of the role of granulocyte-macrophage colony-stimulating factor in animals and man from in vitro results

1994 • 27 citations

Effect of granulocyte colony-stimulating factor on the candidacidal activity of polymorphonuclear neutrophils and their collaboration with fluconazole

1997 • 25 citations

Unusual adverse events following peripheral blood stem cell (PBSC) mobilisation using granulocyte colony stimulating factor (G-CSF) in healthy donors

2000 • 25 citations

Granulocyte colony-stimulating factor treatment in AIDS patients

1992 • 24 citations

Contrasting effects of recombinant human granulocyte-macrophage colony- stimulating factor (CSF) and granulocyte CSF treatment on the cycling of blood elements in childhood-onset cyclic neutropenia

1994 • 24 citations

Systemic Fungal Infections in Patients with Hematologic Malignancies: Indications and Limitations of the Antifungal Armamentarium

1999 • 23 citations

In vivo effects of recombinant human granulocyte colony-stimulating factor on normal neutrophil function and membrane effector molecule expression.

1991 • 21 citations

Use of G-CSF to mobilise PBSC in normal healthy donors--an international survey.

1998 • 19 citations

Human immunodeficiency virus disease-related neutropenia and the risk of hospitalization for bacterial infection

1997 • 18 citations

Polymorphonuclear neutrophils from human immunodeficiency virus- infected patients show enhanced activation, diminished fMLP-induced L- selectin shedding, and an impaired oxidative burst after cytokine priming

1994 • 15 citations

G-CSF in the long-term treatment of cyclic neutropenia and chronic idiopathic neutropenia in adult patients.

1995 • 15 citations

Severe congenital neutropenia unresponsive to G‐CSF

1995 • 13 citations

Differential effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in children with severe congenital neutropenia

1990 • 12 citations

Serum granulocyte colony-stimulating factor levels are not increased in patients with autoimmune neutropenia of infancy

2000 • 12 citations

Killing ofMycobacterium aviumby Neutrophils and Monocytes from AIDS Patients Treated with Recombinant Granulocyte‐Macrophage Colony‐Stimulating Factor

1999 • 11 citations

Hematopoietic growth factors in autologous transplantation

1998 • 9 citations

Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine

1991 • 9 citations

Increased serum levels of granulocyte colony-stimulating factor in patients with severe congenital neutropenia

1991 • 8 citations

Phase I trial of recombinant human macrophage colony-stimulating factor in patients with invasive fungal infections

1991 • 7 citations

Serum granulocyte colony‐stimulating factor levels in patients with chronic neutropenia of childhood: modulation of G‐CSF levels by myeloid precursor cell mass

1999 • 6 citations

Long-term follow-up of patients with invasive fungal disease who received adjunctive therapy with recombinant human macrophage colony- stimulating factor

1993 • 5 citations

Granulocyte and granulocyte-macrophage colony-stimulating factors

1993 • 4 citations

Time and death: Deleuzian concept of ‘future’ as an empty form of time and impersonal death.

2020 • 4 citations

Contrasting effects of recombinant human granulocyte-macrophage colony- stimulating factor (CSF) and granulocyte CSF treatment on the cycling of blood elements in childhood-onset cyclic neutropenia

1994 • 3 citations

In vivo hematologic effects of recombinant human macrophage colony- stimulating factor

1990 • 1 citations

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