Fibrosis and disease progression in hepatitis C

Histological grading and staging of chronic hepatitis

1995 • 4,862 citations

An algorithm for the grading of activity in chronic hepatitis C

1996 • 3,858 citations

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

1981 • 3,549 citations

Natural history of liver fibrosis progression in patients with chronic hepatitis C

1997 • 3,027 citations

Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study

2001 • 1,432 citations

Clinical Outcomes after Transfusion-Associated Hepatitis C

1995 • 1,228 citations

Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity

2001 • 1,065 citations

Clinical Outcomes after Hepatitis C Infection from Contaminated Anti-D Immune Globulin

1999 • 913 citations

Recovery, Persistence, and Sequelae in Hepatitis C Virus Infection: A Perspective on Long-Term Outcome

2000 • 751 citations

HCV-related fibrosis progression following liver transplantation: increase in recent years

2000 • 750 citations

Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis C

2001 • 750 citations

Human immunodeficiency virus infection modified the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis

1997 • 719 citations

Long-Term Mortality after Transfusion-Associated Non-A, Non-B Hepatitis

1992 • 692 citations

Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis

1999 • 685 citations

Estimating progression to cirrhosis in chronic hepatitis C virus infection

2001 • 628 citations

Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients

2002 • 607 citations

The long-term pathological evolution of chronic hepatitis C

1996 • 594 citations

High Incidence of Allograft Cirrhosis in Hepatitis C Virus Genotype 1B Infection Following Transplantation: Relationship With Rejection Episodes

1999 • 547 citations

The Pathology of Hepatitis C

1992 • 539 citations

Matrix as a Modulator of Hepatic Fibrogenesis

2001 • 535 citations

Ratio of Serum Aspartate to Alanine Aminotransferase in Chronic Hepatitis Relationship to Cirrhosis

1988 • 497 citations

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

2001 • 489 citations

Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis [Hepatology 1981;1:431–435]

2003 • 455 citations

Impact of alcohol on the histological and clinical progression of Hepatitis C infection

1998 • 447 citations

Pathological diagnosis of chronic hepatitis C: A multicenter comparative study with chronic hepatitis B

1993 • 373 citations

Low frequency of cirrhosis in a hepatitis C (genotype 1b) single-source outbreak in germany: A 20-year multicenter study

2000 • 354 citations

Effect of alcohol consumption on serum hepatitis C virus RNA and histological lesions in chronic hepatitis C

1998 • 353 citations

The influence of human immunodeficiency virus coinfection on chronic hepatitis C in injection drug users: A long-term retrospective cohort study

2001 • 340 citations

Expression of connective tissue growth factor in experimental rat and human liver fibrosis

1999 • 326 citations

Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminase activity

1998 • 312 citations

Serum aminotransferase levels and platelet counts as predictors of degree of fibrosis in chronic hepatitis C virus infection

2001 • 277 citations

Hepatitis C: the clinical spectrum of the disease

1999 • 263 citations

Histopathology of Hepatitis C Virus Infection

1995 • 262 citations

Natural history of hepatitis C virus carriers with persistently normal aminotransferase levels

2000 • 224 citations

Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex

2000 • 223 citations

Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C

1998 • 207 citations

Hepatic steatosis in chronic hepatitis C virus infection: Prevalence and clinical correlation

2001 • 187 citations

Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis C

1994 • 186 citations

Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: A case-control study

1996 • 180 citations

Prospective study on anti-hepatitis C virus–positive patients with persistently normal serum alanine transaminase with or without detectable serum hepatitis C virus RNA

2001 • 169 citations

Chronic hepatitis C and superimposed nonalcoholic fatty liver disease

2001 • 153 citations

Serum type III procollagen peptide, type IV collagen 7S domain, central triple-helix of type IV collagen and tissue inhibitor of metalloproteinases in patients with chronic viral liver disease: Relationship to liver histology

1994 • 128 citations

Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histolog

1996 • 127 citations

Serum hyaluronan as a marker of liver fibrosis in chronic viral hepatitis C: effect of α-interferon therapy

1995 • 119 citations

Circulating matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 as serum markers of fibrosis in patients with chronic hepatitis C

1997 • 108 citations

Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids.

1997 • 103 citations

Genetic complexity of the hypervariable region 1 (HVR1) of hepatitis C virus (HCV): Influence on the characteristics of the infection and responses to interferon alfa therapy in patients with chronic hepatitis C

1998 • 101 citations

EFFECT OF ALCOHOL CONSUMPTION ON THE PROGRESSION OF HEPATITIS C VIRUS INFECTION AND RISK OF HEPATOCELLULAR CARCINOMA IN JAPANESE PATIENTS

2000 • 98 citations

Clinical significance of intrahepatic hepatitis C virus levels in patients with chronic HCV infection

1998 • 92 citations

Additive activation of hepatic NF‐κB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF‐α receptor 1‐independent and ‐dependent mechanisms

2001 • 88 citations

Hepatic stellate cell activation and liver fibrosis are associated with necroinflammatory injury and Thl‐like response in chronic hepatitis C

1999 • 80 citations

Liver stellate cells in chronic viral hepatitis: the effect of interferon therapy

1996 • 80 citations

Extracellular matrix : chemistry, biology, and pathobiology with emphasis on the liver

1993 • 59 citations

SERUM TUMOUR NECROSIS FACTOR-α AND TRANSFORMING GROWTH FACTOR-β LEVELS IN CHRONIC HEPATITIS C PATIENTS ARE IMMUNOMODULATED BY THERAPY

2002 • 49 citations

Serum hyaluronan as a marker of liver fibrosis.

1995 • 48 citations

Histological features predictive of liver fibrosis in chronic hepatitis C infection.

1996 • 43 citations

Serum laminin and type III procollagen in chronic hepatitis C. Diagnostic value in the assessment of disease activity and fibrosis

1997 • 41 citations

Quantitation of hepatic hepatitis C virus RNA in patients with chronic hepatitis C. Relationship with severity of disease, viral genotype and response to treatment

2001 • 35 citations

Detection and quantitation of serum HCV-RNA by branched DNA amplification in anti-HCV positive blood donors

1994 • 34 citations

Transforming growth factor beta 1: in situ expression in the liver of patients with chronic hepatitis C treated with alpha interferon.

1993 • 26 citations

Confidentiality, death and the doctor.

1996 • 24 citations

Hypervariable region 1 quasispecies in hepatitis C virus genotypes 1b and 3 infected patients with normal and abnormal alanine aminotransferase levels

2002 • 24 citations

Genotype 1 is associated with a slower progression of fibrosis in untreqted patients with mild chronic hepatitis C

2001 • 8 citations

The cellular origin of extracellular matrix constituents

1993 • 8 citations

Role of IL12 in genetic immunization against WHV-core antigen: induction of TH1 immune responses and protection against woodchuck hepatitis virus (WHV)

2001 • 5 citations

Detection and quantitation of serum hepatitis C virus (HCV) RNA by branched DNA amplification in anti-HCV positive blood donors

1994 • 4 citations