Interferon Alfa-2b Alone or in Combination with Ribavirin for the Treatment of Relapse of Chronic Hepatitis C

The design and analysis of clinical experiments

1986 • 4,401 citations

An algorithm for the grading of activity in chronic hepatitis C

1996 • 3,858 citations

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

1981 • 3,549 citations

Sequential Treatment Assignment with Balancing for Prognostic Factors in the Controlled Clinical Trial

1975 • 2,224 citations

Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa

1989 • 1,658 citations

Recombinant Interferon Alfa Therapy for Chronic Hepatitis C

1989 • 1,233 citations

Epidemiology of hepatitis C

1997 • 1,112 citations

Significance of serum hepatitis C virus RNA levels in chronic hepatitis C

1993 • 822 citations

Long-Term Mortality after Transfusion-Associated Non-A, Non-B Hepatitis

1992 • 692 citations

Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: Effects of dose and duration

1996 • 675 citations

National Institutes of Health Consensus Development Conference Panel statement: Management of hepatitis C

1997 • 572 citations

Long-Term Histologic Improvement and Loss of Detectable Intrahepatic HCV RNA in Patients with Chronic Hepatitis C and Sustained Response to Interferon-α Therapy

1997 • 571 citations

Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C

1995 • 474 citations

A Comparison of Three Interferon Alfa-2b Regimens for the Long-Term Treatment of Chronic Non-A, Non-B Hepatitis

1995 • 465 citations

EPIDEMIOLOGY OF HEPATITIS

1965 • 438 citations

Side effects of ? interferon in chronic hepatitis C

1997 • 396 citations

Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: A multicenter trial

1997 • 384 citations

Ribavirin treatment for patients with chronic hepatitis C: results of a placebo-controlled study

1996 • 360 citations

Factors predictive of a beneficial response to therapy of hepatitis C

1997 • 339 citations

Interferon for non-A, non-B chronic hepatitis

1991 • 294 citations

A pilot study of combination therapy with ribavirin plus interferon alfa for interferon alfa-resistant chronic hepatitis C

1994 • 292 citations

A pilot study of ribavirin therapy for chronic hepatitis C

1992 • 291 citations

Molecular Mechanisms of Action of Ribavirin

1990 • 284 citations

Therapy of hepatitis C: Meta-analysis of interferon alfa-2b trials

1997 • 259 citations

Non-A, Non-B Post-Transfusion Hepatitis: Looking Back in the Second Decade

1993 • 239 citations

Therapy of hepatitis C: Overview

1997 • 221 citations

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: definition of optimal conditions for specimen collection and clinical application in interferon-treated patients.

1994 • 193 citations

Comparison of plasma virus loads among individuals infected with hepatitis C virus (HCV) genotypes 1, 2, and 3 by quantiplex HCV RNA assay versions 1 and 2, Roche Monitor assay, and an in-house limiting dilution method

1997 • 169 citations

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: Definition of optimal conditions for specimen collection and clinical application in interferon-treated patients

1994 • 150 citations

Prediction of response to interferon treatment of chronic hepatitis C

1994 • 130 citations

The effect of interferon alfa and ribavirin combination therapy in naive patients with chronic hepatitis C.

1995 • 123 citations

Interferon alfa-2b for chronic hepatitis C: effects of dose increment and duration of treatment on response rates

1995 • 121 citations

Prospective study of plasma fibronectin in fulminant hepatitis: association with infection and mortality

1995 • 112 citations

Combined treatment with interferon alpha‐2b and ribavirin for chronic hepatitis C in patients with a previous non‐response or non‐sustained response to interferon alone

1995 • 112 citations

LIVER TRANSPLANTATION FOR CHRONIC VIRAL HEPATITIS

1999 • 109 citations

Outcome of acute symptomatic non‐A, non‐B hepatitis: a 13‐year follow‐up study of hepatitis C virus markers

1993 • 108 citations

Two-year biochemical, virological, and histological follow-up in patients with chronic hepatitis C responding in a sustained fashion to interferon alfa-2b treatment

1995 • 105 citations

Therapy of hepatitis C: Re-treatment with alpha interferon

1997 • 103 citations

Therapy of hepatitis C: Consensus interferon trials

1997 • 97 citations

Hepatic Hepatitis C Virus RNA as a Predictor of a Long-Term Response to Interferon-α Therapy

1995 • 96 citations

Mini-microabscess syndrome in liver transplant recipients

1997 • 45 citations

Retreatment of chronic hepatitis C with interferon.

1994 • 35 citations

High-dose interferon-α2b for re-treatment of nonresponders or relapsing patients with chronic hepatitis C

1996 • 33 citations

Improved sustained response following treatment of chronic hepatitis C by gradual reduction in the interferon dose

1996 • 32 citations