Course and outcome of hepatitis C

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection

2002 • 6,505 citations

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

2001 • 6,133 citations

Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C

1998 • 3,550 citations

An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

1989 • 3,401 citations

The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994

1999 • 3,083 citations

Hepatitis C Virus Infection

2001 • 2,979 citations

Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

1999 • 2,796 citations

Classification of chronic hepatitis: Diagnosis, grading and staging

1994 • 2,506 citations

Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus

1998 • 2,374 citations

Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

1998 • 2,112 citations

Natural history of chronic hepatitis C

2002 • 1,460 citations

Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients

1997 • 1,426 citations

Efficient Initiation of HCV RNA Replication in Cell Culture

2000 • 1,412 citations

A Role for Hepatitis C Virus Infection in Type II Cryoglobulinemia

1992 • 1,302 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Recommendations for Prevention and Control of Hepatitis C Virus (HCV) Infection and HCV-Related Chronic Disease

1998 • 1,246 citations

Clinical Outcomes after Transfusion-Associated Hepatitis C

1995 • 1,228 citations

Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

2001 • 1,183 citations

The Natural History of Hepatitis C Virus Infection

2000 • 1,078 citations

Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution

1992 • 938 citations

Clinical Outcomes after Hepatitis C Infection from Contaminated Anti-D Immune Globulin

1999 • 913 citations

Membranoproliferative Glomerulonephritis Associated with Hepatitis C Virus Infection

1993 • 894 citations

The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies

2000 • 892 citations

Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C

2000 • 885 citations

Hepatitis C virus replication in mice with chimeric human livers

2001 • 870 citations

Genetic Heterogeneity of Hepatitis C Virus: Quasispecies and Genotypes

1995 • 855 citations

Hepatitis C: The clinical spectrum of disease

1997 • 768 citations

Lack of Protective Immunity Against Reinfection with Hepatitis C Virus

1992 • 760 citations

Recovery, Persistence, and Sequelae in Hepatitis C Virus Infection: A Perspective on Long-Term Outcome

2000 • 751 citations

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

2000 • 747 citations

Routes of Infection, Viremia, and Liver Disease in Blood Donors Found to Have Hepatitis C Virus Infection

1996 • 649 citations

Hepatitis C Virus-Encoded Enzymatic Activities and Conserved RNA Elements in the 3′ Nontranslated Region Are Essential for Virus Replication In Vivo

2000 • 594 citations

Interferon Alfa-2a Therapy in Cryoglobulinemia Associated with Hepatitis C Virus

1994 • 589 citations

A Long-Term Study of Hepatitis C Virus Replication in Non-A, Non-B Hepatitis

1991 • 575 citations

Extrahepatic Manifestations Associated with Hepatitis C Virus Infection: A Prospective Multicenter Study of 321 Patients

2000 • 566 citations

Hepatitis C Virus Infection in Patients with Essential Mixed Cryoglobulinemia

1992 • 535 citations

Immunological disorders in C virus chronic active hepatitis: A prospective case-control study

1994 • 512 citations

Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization

1998 • 511 citations

Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection

1999 • 490 citations

Lymphocytic sialadenitis of Sjögren's syndrome associated with chronic hepatitis C virus liver disease

1992 • 483 citations

Prevalence and Clinical Outcome of Hepatitis C Infection in Children Who Underwent Cardiac Surgery before the Implementation of Blood-Donor Screening

1999 • 482 citations

Protection against persistence of hepatitis C

2002 • 439 citations

Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence

1999 • 419 citations

Hepatitis C Virus Infection in Patients with B-Cell Non-Hodgkin Lymphoma

1997 • 399 citations

Association of Hepatitis C Virus–Specific CD8⁺T Cells with Viral Clearance in Acute Hepatitis C

2000 • 362 citations

Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders

1996 • 359 citations

Low frequency of cirrhosis in a hepatitis C (genotype 1b) single-source outbreak in germany: A 20-year multicenter study

2000 • 354 citations

Long–Term Mortality and Morbidity of Transfusion–Associated Non–A, Non–B, and Type C Hepatitis: A National Heart, Lung, and Blood Institute Collaborative Study

2001 • 324 citations

The molecular virology of hepatitis C

1997 • 319 citations

Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children

1994 • 283 citations

Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in north america

1998 • 273 citations

Volunteer Blood Donors with Antibody to Hepatitis C Virus: Clinical, Biochemical, Virologic, and Histologic Features

1995 • 264 citations

A Phylogenetically Conserved Stem-Loop Structure at the 5′ Border of the Internal Ribosome Entry Site of Hepatitis C Virus Is Required for Cap-Independent Viral Translation

1999 • 255 citations

The spectrum of liver disease in the general population: lesson from the Dionysos study

2001 • 240 citations

Differences in Viral Dynamics between Genotypes 1 and 2 of Hepatitis C Virus

2000 • 230 citations

Genotypic analysis of hepatitis C virus in American patients

1994 • 200 citations

Distribution of Hepatitis C Virus Genotypes Determined by Line Probe Assay in Patients with Chronic Hepatitis C Seen at Tertiary Referral Centers in the United States

1996 • 197 citations

Hepatitis C Virus–Associated Fulminant Hepatic Failure

1996 • 194 citations

Quantification of the initial decline of serum hepatitis c virus RNA and response to interferon alfa

1998 • 171 citations

Prospective study on anti-hepatitis C virus–positive patients with persistently normal serum alanine transaminase with or without detectable serum hepatitis C virus RNA

2001 • 169 citations

A role for hepatitis C virus infection in type II cryoglobulinemia Agnello V., Chung R.T., Kaplan L.M. N Engl J Med 1992;327:1490–1495

1993 • 168 citations

Early events in hepatitis C virus infection of chimpanzees.

1990 • 165 citations

Relationship of aminotransferases to liver histological status in chronic hepatitis C.

1995 • 158 citations

Vaccination of Chimpanzees With Plasmid DNA Encoding the Hepatitis C Virus(HCV) Envelope E2 Protein Modified the Infection After Challenge With Homologous Monoclonal HCV

2000 • 157 citations

Long-Term Follow-Up of Chimpanzees Inoculated with the First Infectious Clone for Hepatitis C Virus

1999 • 152 citations

Peginterferon alfa-2A (40 KD) (PEGASYS) in combination with ribavirin (RBV): efficacy and safety results from a phase III, randomized, double-blind, multicentre study examining effect of duration of treatment and RBV dose

2002 • 143 citations

Liver steatosis in chronic hepatitis C: a morphological sign suggesting infection with HCV genotype 3

2001 • 132 citations

Hepatitis C in African Americans: Summary of a workshop

2000 • 132 citations

Neurological manifestations of chronic hepatitis C

1999 • 112 citations

Evaluation of branched DNA signal amplification for the detection of hepatitis C virus RNA

1995 • 97 citations

The Hepatitis C Virus (HCV)–Trimera Mouse: A Model for Evaluation of Agents against HCV

2002 • 90 citations

Hepatitis C virus infection and lymphoproliferative diseases: Prospective study on 1,576 patients in France

2001 • 90 citations

Hepatitis C infection among survivors of childhood cancer

2000 • 86 citations

Clinical outcome of hypogammaglobulinaemic patients following outbreak of acute hepatitis C: 2 year follow up

1997 • 83 citations

Clinical and Histopathologic Analysis of the Relationship between Lichen Planus and Chronic Hepatitis C

1995 • 83 citations

Treatment of autoimmune and extrahepatic manifestations of hepatitis C virus infection

1999 • 69 citations

Spontaneous negativation of serum hepatitis C virus RNA is a rare event in type C chronic liver diseases: analysis of HCV RNA in 320 patients who were followed for more than 3 years

1999 • 49 citations

Stability of HCV‐RNA level and its lack of correlation with disease severity in asymptomatic chronic hepatitis C virus carriers

2001 • 46 citations

Loss of Circulating Hepatitis C Virus in Children Who Developed a Persistent Carrier State after Mother-to-Baby Transmission

1997 • 41 citations

Perspectives for a vaccine against hepatitis C virus

1999 • 40 citations