The ATM-mediated DNA-damage response: taking shape

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

2003 • 2,569 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

2005 • 1,364 citations

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

2005 • 1,209 citations

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

1999 • 1,052 citations

Requirement of the MRN complex for ATM activation by DNA damage

2003 • 1,043 citations

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

2005 • 1,036 citations

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

2005 • 1,034 citations

H2AX: the histone guardian of the genome

2004 • 978 citations

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

2000 • 922 citations

Choreography of the DNA Damage Response

2004 • 881 citations

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

2004 • 859 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

2004 • 819 citations

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

2003 • 767 citations

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

2004 • 724 citations

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

2005 • 692 citations

RecQ helicases: caretakers of the genome

2003 • 676 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

2006 • 615 citations

MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

2006 • 601 citations

Cellular Responses to DNA Damage

2001 • 591 citations

The role of double-strand break repair — insights from human genetics

2005 • 560 citations

Initiating Cellular Stress Responses

2004 • 543 citations

Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

2006 • 504 citations

DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy

2003 • 490 citations

The Mre11 complex is required for ATM activation and the G2/M checkpoint

2003 • 489 citations

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

2004 • 472 citations

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

2003 • 463 citations

PI 3-kinase related kinases: ‘big’ players in stress-induced signaling pathways

2004 • 433 citations

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

2005 • 417 citations

Ataxia–telangiectasia, an evolving phenotype

2004 • 412 citations

Human cell senescence as a DNA damage response

2004 • 403 citations

The Fanconi Anemia/BRCA pathway: new faces in the crowd

2005 • 398 citations

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

2004 • 395 citations

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

2004 • 385 citations

Nucleotide Excision Repair

2005 • 349 citations

The p53 response to DNA damage

2004 • 329 citations

The cellular response to general and programmed DNA double strand breaks

2004 • 300 citations

Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

2006 • 292 citations

Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle

2005 • 277 citations

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

2005 • 276 citations

Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

2001 • 275 citations

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

2005 • 272 citations

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A

2004 • 261 citations

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

2004 • 259 citations

Ataxia-telangiectasia-like disorder (ATLD)—its clinical presentation and molecular basis

2004 • 255 citations

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

2005 • 249 citations

A Role for Proapoptotic BID in the DNA-Damage Response

2005 • 232 citations

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

2006 • 227 citations

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

2005 • 226 citations

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

2006 • 221 citations

The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination

2004 • 221 citations

Proapoptotic BID Is an ATM Effector in the DNA-Damage Response

2005 • 220 citations

Role of DNA–PK in the cellular response to DNA double-strand breaks

2004 • 218 citations

The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

2005 • 202 citations

The DNA damage response: sensing and signaling

2004 • 201 citations

53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

2003 • 196 citations

An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

2004 • 195 citations

Regulation of DNA replication by ATR: signaling in response to DNA intermediates

2004 • 192 citations

Ataxia Telangiectasia Mutated (ATM) and ATM and Rad3-related Protein Exhibit Selective Target Specificities in Response to Different Forms of DNA Damage

2004 • 192 citations

Homologous recombination-mediated double-strand break repair

2004 • 192 citations

The Mre11/Rad50/Nbs1 Complex and Its Role as a DNA Double-Strand Break Sensor for ATM

2005 • 181 citations

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

2005 • 181 citations

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway

2004 • 173 citations

Nbs1 is required for ATR-dependent phosphorylation events

2004 • 169 citations

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

2004 • 169 citations

ATM-Dependent Phosphorylation of ATF2 Is Required for the DNA Damage Response

2005 • 167 citations

ATM-Mediated Phosphorylations Inhibit Mdmx/Mdm2 Stabilization by HAUSP in Favor of p53 Activation

2005 • 164 citations

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

2006 • 156 citations

53BP1, an activator of ATM in response to DNA damage

2004 • 150 citations

ATM Activation in Normal Human Tissues and Testicular Cancer

2005 • 148 citations

The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM

2006 • 134 citations

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

2005 • 130 citations

Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor Suppression

2005 • 127 citations

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

2004 • 123 citations

Structure of the BRCT Repeat Domain of MDC1 and Its Specificity for the Free COOH-terminal End of the γ-H2AX Histone Tail

2005 • 123 citations

MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes

2004 • 115 citations

Requirement of the Mre11 Complex and Exonuclease 1 for Activation of the Mec1 Signaling Pathway

2004 • 113 citations

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

2004 • 107 citations

Genomic instability and cancer: Networks involved in response to DNA damage

2005 • 106 citations

Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses

2003 • 104 citations

Imaging of protein movement induced by chromosomal breakage: tiny ‘local’ lesions pose great ‘global’ challenges

2005 • 98 citations

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress

2004 • 97 citations

Current advances in unraveling the function of the Werner syndrome protein

2005 • 95 citations

Artemis links ATM to Double Strand Break Rejoining

2005 • 94 citations

Quantitative neurologic assessment of ataxia-telangiectasia

2000 • 94 citations

Active Role for Nibrin in the Kinetics of Atm Activation

2006 • 91 citations

Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.

2005 • 89 citations

Independent Roles for Nibrin and Mre11-Rad50 in the Activation and Function of Atm

2004 • 86 citations

The Rad50^S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor

2005 • 85 citations

Clinical features of Bloom syndrome and function of the causative gene, BLM helicase

2004 • 81 citations

The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks

2004 • 77 citations

Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue

2005 • 74 citations

Differentiation-Induced Radioresistance in Muscle Cells

2004 • 70 citations

Crosslinks and crosstalk

2004 • 63 citations

ATM and the DNA damage response

2006 • 54 citations

Network responses to DNA damaging agents

2004 • 53 citations

ATM and ATR Check in on Origins: A Dynamic Model for Origin Selection and Activation

2004 • 47 citations

Maintaining integrity

2004 • 47 citations

The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways

2004 • 46 citations

DNA Damage Processing Defects and Disease

2001 • 43 citations

DNA Replication Stress-induced Phosphorylation of Cyclic AMP Response Element-binding Protein Mediated by ATM

2005 • 34 citations

Crosslinks and crosstalkHuman cancer syndromes and DNA repair defects

2004 • 27 citations

NFBD1/Mdc1 Mediates ATR-Dependent DNA Damage Response

2005 • 21 citations

In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia

2004 • 16 citations