Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Transcriptional regulation by the phosphorylation-dependent factor CREB

2001 • 2,488 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

1998 • 1,504 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

One‐thousand‐and‐one substrates of protein kinase CK2?

2003 • 1,292 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

1996 • 851 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Disruption of CREB function in brain leads to neurodegeneration

2002 • 674 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System

1998 • 425 citations

Phosphorylation of CREB at Ser-133 Induces Complex Formation with CREB-Binding Protein via a Direct Mechanism

1996 • 396 citations

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

2002 • 356 citations

Apoptosis, Axonal Growth Defects, and Degeneration of Peripheral Neurons in Mice Lacking CREB

2002 • 344 citations

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein

1998 • 302 citations

CREB Transcriptional Activity in Neurons Is Regulated by Multiple, Calcium-Specific Phosphorylation Events

2002 • 286 citations

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

2001 • 276 citations

Genome-Wide Analysis of CREB Target Genes Reveals A Core Promoter Requirement for cAMP Responsiveness

2003 • 253 citations

Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs

1999 • 247 citations

Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.

2001 • 231 citations

Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressers

1993 • 169 citations

Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?

1997 • 158 citations

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

2000 • 150 citations

Binding of p53 to the KIX Domain of CREB Binding Protein

1999 • 108 citations

Superoxide stress identifies neurons at risk in a model of ataxia‐telangiectasia

2001 • 106 citations

Accumulation of DNA Damage and Reduced Levels of Nicotine Adenine Dinucleotide in the Brains of Atm-deficient Mice

2002 • 100 citations

Protective roles for ATM in cellular response to oxidative stress

2000 • 97 citations

Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains

1999 • 76 citations

Cell-cycle-regulated phosphorylation of cAMP response element-binding protein: identification of novel phosphorylation sites

1999 • 35 citations

Ataxia-Telangiectasia

2001 • 34 citations