The Rad50^S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

2005 • 1,364 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

2005 • 1,209 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

1999 • 1,052 citations

Requirement of the MRN complex for ATM activation by DNA damage

2003 • 1,043 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

2002 • 857 citations

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

1996 • 851 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

2000 • 781 citations

Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

2005 • 592 citations

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

2002 • 556 citations

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

2000 • 546 citations

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

2003 • 545 citations

Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

2002 • 511 citations

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway

2004 • 507 citations

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

1997 • 504 citations

The Mre11 complex is required for ATM activation and the G2/M checkpoint

2003 • 489 citations

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

2000 • 484 citations

Histone H2AX

2003 • 479 citations

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

2002 • 476 citations

ATM-dependent phosphorylation of nibrin in response to radiation exposure

2000 • 474 citations

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

2000 • 446 citations

Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination

1997 • 438 citations

PI 3-kinase related kinases: ‘big’ players in stress-induced signaling pathways

2004 • 433 citations

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

2005 • 417 citations

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1996 • 415 citations

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

1999 • 402 citations

Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

2002 • 393 citations

A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex

2001 • 384 citations

The cellular response to DNA double-strand breaks: defining the sensors and mediators

2003 • 336 citations

Deletion mapping of DNA regions required for SV40 early region promoter function in vivo.

1982 • 328 citations

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

2004 • 259 citations

Mismatch repair-dependent G₂ checkpoint induced by low doses of S_N1 type methylating agents requires the ATR kinase

2004 • 240 citations

mre11S—a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis

1997 • 239 citations

The Mre11 complex and ATM: collaborating to navigate S phase

2000 • 234 citations

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

2005 • 226 citations

A Novel mre11 Mutation Impairs Processing of Double-Strand Breaks of DNA during Both Mitosis and Meiosis

1998 • 220 citations

The mRNA Surveillance Protein hSMG-1 Functions in Genotoxic Stress Response Pathways in Mammalian Cells

2004 • 220 citations

A Murine Model of Nijmegen Breakage Syndrome

2002 • 206 citations

Cancer predisposition and hematopoietic failure in Rad50^S/S mice

2002 • 205 citations

Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast.

1995 • 200 citations

53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

2003 • 196 citations

Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression

2004 • 190 citations

Nbs1 is required for ATR-dependent phosphorylation events

2004 • 169 citations

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

2002 • 168 citations

Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice

2003 • 167 citations

Abnormalities of the Immune System Induced by Dysregulated bcl-2 Expression in Transgenic Mice

1990 • 129 citations

Tumorigenesis in mice carrying a truncating Brca1 mutation

2001 • 129 citations

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

2004 • 123 citations

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

2004 • 107 citations

Repair of Topoisomerase-Mediated DNA Damage in Bacteriophage T4

2001 • 23 citations

Genome instability and Rad50S: subtle yet severe

2002 • 18 citations