Genomic instability and cancer: Networks involved in response to DNA damage

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

DNA double-strand breaks: signaling, repair and the cancer connection

2001 • 2,372 citations

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

2002 • 1,676 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Biallelic Inactivation of BRCA2 in Fanconi Anemia

2002 • 1,138 citations

The age of cancer

2000 • 949 citations

Protection of mammalian telomeres

2002 • 926 citations

The Fanconi anaemia/BRCA pathway

2003 • 819 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

2001 • 691 citations

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

2002 • 679 citations

In search of the tumour-suppressor functions of BRCA1 and BRCA2

2000 • 638 citations

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

2000 • 600 citations

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1995 • 585 citations

A novel ubiquitin ligase is deficient in Fanconi anemia

2003 • 565 citations

Centrosome amplification drives chromosomal instability in breast tumor development

2002 • 564 citations

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2

1997 • 531 citations

A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes

1996 • 525 citations

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

2001 • 471 citations

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

1999 • 421 citations

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

1998 • 389 citations

The Bloom's Syndrome Gene Product Is a 3′-5′ DNA Helicase

1997 • 378 citations

Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations.

1997 • 362 citations

Insights into the functions of BRCA1 and BRCA2

2000 • 335 citations

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

1998 • 325 citations

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

2000 • 315 citations

BRCA1 is associated with the centrosome during mitosis

1998 • 311 citations

Study of a single BRCA2 mutation with high carrier frequency in a small population.

1997 • 293 citations

Interaction of FANCD2 and NBS1 in the DNA damage response

2002 • 274 citations

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

2004 • 255 citations

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

2001 • 251 citations

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

2003 • 239 citations

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair

2002 • 234 citations

Inactivation of BRCA1 and BRCA2 in Ovarian Cancer

2002 • 216 citations

Telomere dysfunction and the initiation of genome instability

2003 • 212 citations

Tracing the network connecting brca and fanconi anaemia proteins

2004 • 201 citations

BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition

2004 • 198 citations

Shared Genetic Susceptibility to Breast Cancer, Brain Tumors, and Fanconi Anemia

2003 • 195 citations

An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

2004 • 195 citations

BRCA2 mutation in Icelandic prostate cancer patients

1997 • 150 citations

BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability.

1998 • 133 citations

Aurora-A Kinase Regulates Telomerase Activity through c-Myc in Human Ovarian and Breast Epithelial Cells

2004 • 122 citations

Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

2001 • 120 citations

Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases.

1999 • 117 citations

New complexities for BRCA1 and BRCA2

2001 • 115 citations

Identification of a gamma-tubulin-binding domain in BRCA1.

2001 • 109 citations

Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells

2002 • 104 citations

Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers

1997 • 102 citations

Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia

2002 • 99 citations

The effect of a single BRCA2 mutation on cancer in Iceland

2002 • 90 citations

Prognostic significance of BRCA1 expression in sporadic breast carcinomas

2003 • 68 citations

Chromosome stability, DNA recombination and the BRCA2 tumour suppressor

2001 • 56 citations

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

2002 • 56 citations

Effects of double-strand break repair proteins on vertebrate telomere structure

2002 • 54 citations

The Icelandic founder mutation BRCA2 999del5: analysis of expression

2004 • 52 citations

Identification of a novel splice-site mutation of the BRCA1 gene in two breast cancer families: Screening reveals low frequency in Icelandic breast cancer patients

1998 • 44 citations

BRCA1 and BRCA2 in hereditary breast cancer

2002 • 38 citations

Multiple copies of mutantBRCA1 andBRCA2 alleles in breast tumors from germ-line mutation carriers

2000 • 32 citations

The YeastTEL1Gene Partially Substitutes for HumanATMin Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells

2000 • 31 citations

DNA and telomeres: beginnings and endings

2004 • 29 citations

Take care of your chromosomes lest cancer take care of you

2003 • 28 citations

Differing effects of breast cancer 1, early onset (BRCA1) and ataxia‐telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation

2003 • 16 citations

Workshop on The Epidemiology of the ATMGene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002

2002 • 4 citations