FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

2002 • 1,506 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

2006 • 1,430 citations

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

2000 • 1,326 citations

FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation

2004 • 1,294 citations

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

2006 • 1,278 citations

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

2006 • 1,273 citations

FOXO transcription factors at the interface between longevity and tumor suppression

2005 • 1,250 citations

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

2004 • 1,126 citations

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

1994 • 1,109 citations

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1999 • 1,102 citations

Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation

2004 • 1,008 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a

2003 • 898 citations

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

2002 • 849 citations

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

2006 • 815 citations

Redox Regulation of Forkhead Proteins Through a p66shc -Dependent Signaling Pathway

2002 • 810 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling

2005 • 716 citations

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

2004 • 660 citations

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

2003 • 644 citations

Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

2005 • 610 citations

Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors

2002 • 435 citations

Regulation of NF-κB, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a

2004 • 407 citations

Forkhead-box transcription factors and their role in the immune system

2004 • 404 citations

In Vitro Maintenance of Highly Purified, Transplantable Hematopoietic Stem Cells

1997 • 390 citations

P<scp>hosphoinositide</scp>3-K<scp>inase</scp>: Diverse Roles in Immune Cell Activation

2004 • 341 citations

Abnormal Angiogenesis in Foxo1 (Fkhr)-deficient Mice

2004 • 328 citations

Forkhead transcription factors contribute to execution of the mitotic programme in mammals

2001 • 282 citations

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

1997 • 247 citations

AF6q21, a Novel Partner of the MLL Gene in t(6; 11)(q21; q23), Defines a Forkhead Transcriptional Factor Subfamily

1997 • 215 citations

Control of Cyclin G2 mRNA Expression by Forkhead Transcription Factors: Novel Mechanism for Cell Cycle Control by Phosphoinositide 3-Kinase and Forkhead

2004 • 201 citations

Cloning and characterization of the t(X;II) breakpoint from a leukemic cell line identify a new member of the forkhead gene family

1994 • 155 citations

FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins

2004 • 118 citations

A Member of Forkhead Transcription Factor FKHRL1 Is a Downstream Effector of STI571-induced Cell Cycle Arrest in BCR-ABL-expressing Cells

2003 • 110 citations

NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a

2004 • 104 citations

Regulation of hematopoietic stem cell growth

2004 • 91 citations