Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Cancer Cell Cycles

1996 • 5,379 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

The Multiple Roles of PTEN in Tumor Suppression

2000 • 1,150 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

2001 • 850 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27^KIP1

2000 • 609 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 608 citations

p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human Cancers

1999 • 594 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1999 • 572 citations

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

2000 • 569 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 483 citations

Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

2000 • 415 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

Gene disruption of p27 ^Kip1 allows cell proliferation in the postnatal and adult organ of Corti

1999 • 359 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

1998 • 337 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1998 • 322 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

2000 • 273 citations

Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation

1998 • 266 citations

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

1995 • 253 citations

The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G₀ Cell State From a G₁ Cell State

1996 • 222 citations

Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts

1996 • 203 citations

Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver

1998 • 195 citations

E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability

2000 • 189 citations

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

1995 • 129 citations

A new pathway for mitogen-dependent Cdk2 regulation uncovered in p27Kip1-deficient cells

1999 • 120 citations

Phenotype vs Genotype in the Evolution of Astrocytic Brain Tumors

2000 • 116 citations

Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage

2001 • 108 citations

Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block

2001 • 107 citations

Regulation of Exit from Quiescence by p27 and Cyclin D1-CDK4

1998 • 93 citations

Correlations of partial and extensive methylation at the p14ARF locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors

2000 • 89 citations

Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer.

1998 • 85 citations

G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4.

1996 • 77 citations

Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells

1999 • 76 citations

Specific Activation of p85-p110 Phosphatidylinositol 3′-Kinase Stimulates DNA Synthesis by ras- and p70 S6 Kinase-Dependent Pathways

1997 • 71 citations

A Pivotal Role of Cyclin D3 and Cyclin-Dependent Kinase Inhibitor p27 in the Regulation of IL-2-, IL-4-, or IL-10-Mediated Human B Cell Proliferation

1998 • 67 citations

An element in intron 1 of the CFTR gene augments intestinal expression in vivo

2001 • 65 citations

p21ras: An oncoprotein functioning in growth factor-induced signal transduction

1995 • 65 citations

Adenoviral RB2/p130 Gene Transfer Inhibits Smooth Muscle Cell Proliferation and Prevents Restenosis After Angioplasty

1999 • 65 citations

Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer.

1996 • 64 citations

The retinoblastoma-like protein p130 is involved in the determination of reserve cells in differentiating myoblasts

2000 • 58 citations

E2F-Rb Complexes Assemble and Inhibit cdc25A Transcription in Cervical Carcinoma Cells following Repression of Human Papillomavirus Oncogene Expression

2000 • 52 citations

The molecular genetics of central nervous system tumors

1998 • 46 citations

Transcriptional repression of the E2F-1 gene by interferon-α is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes

1999 • 42 citations

Chemosensory regulation of development in C. elegans

1993 • 41 citations

Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo.

2000 • 31 citations

Modulation of E2F Complexes during G0 to S Phase Transition in Human Primary B-lymphocytes

1999 • 27 citations

Activation of NF-.KAPPA.B Determines the Sensitivity of Human Colon Cancer Cells to TNF.ALPHA.-Induced Apoptosis.

2000 • 26 citations

Expression and modulation of p42/p44 MAPKs and cell cycle regulatory proteins in rat pancreas regeneration

1999 • 26 citations