Zinc and Disease of the Brain

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

Copper, iron and zinc in Alzheimer's disease senile plaques

1998 • 2,035 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins

1992 • 966 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Histochemical demonstration of heavy metals

1981 • 758 citations

ZINC AND BRAIN INJURY

1998 • 757 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Transition Metals in Control of Gene Expression

1993 • 629 citations

Zn2+: a novel ionic mediator of neural injury in brain disease

2000 • 581 citations

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT 3 gene

1999 • 534 citations

A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain

1987 • 525 citations

Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

1997 • 486 citations

Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry

1997 • 463 citations

Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc

2000 • 389 citations

Induction of Neuronal Apoptosis by Thiol Oxidation

2000 • 376 citations

Zinc-Induced Cortical Neuronal Death: Contribution of Energy Failure Attributable to Loss of NAD⁺and Inhibition of Glycolysis

2000 • 354 citations

Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey

1997 • 352 citations

Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat

1983 • 351 citations

Oral Zinc in Macular Degeneration

1988 • 350 citations

Translocation of zinc may contribute to seizure-induced death of neurons

1989 • 347 citations

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

2000 • 339 citations

Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes

2000 • 326 citations

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat

1990 • 303 citations

Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury

2000 • 285 citations

Exposing Rats to a Predator Blocks Primed Burst Potentiation in the HippocampusIn Vitro

1999 • 275 citations

Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals

1999 • 270 citations

Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.

1991 • 268 citations

Accumulation of Zinc in Degenerating Hippocampal Neurons of ZnT3-Null Mice after Seizures: Evidence against Synaptic Vesicle Origin

2000 • 227 citations

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

1990 • 218 citations

NADE, a p75NTR-associated Cell Death Executor, Is Involved in Signal Transduction Mediated by the Common Neurotrophin Receptor p75NTR

2000 • 202 citations

Metallothioneins in Brain—The Role in Physiology and Pathology

1997 • 201 citations

Poly(ADP-ribose) Polymerase-1 in the Nervous System

2000 • 196 citations

Nonproteolytic Neuroprotection by Human Recombinant Tissue Plasminogen Activator

1999 • 146 citations

Non-equivalent Roles for the First and Second Zinc Fingers of Protein Kinase Cδ

1996 • 133 citations

Histochemically Reactive Zinc in Plaques of the Swedish Mutant β-Amyloid Precursor Protein Transgenic Mice

1999 • 132 citations

Induction of an Immediate Early Gene egr‐1 by Zinc Through Extracellular Signal‐Regulated Kinase Activation in Cortical Culture

1999 • 127 citations

Mediation by Membrane Protein Kinase C of Zinc‐Induced Oxidative Neuronal Injury in Mouse Cortical Cultures

1999 • 125 citations

Co-Induction of p75^NTRand p75^NTR-Associated Death Executor in Neurons After Zinc Exposure in Cortical Culture or Transient Ischemia in the Rat

2000 • 116 citations

L-type Ca2+ channel-mediated Zn2+ toxicity and modulation by ZnT-1 in PC12 cells11Published on the World Wide Web on 12 October 2000.

2000 • 106 citations

Zinc ion binding to human brain calcium binding proteins. Calmodulin and S100b protein

1983 • 99 citations

Metal ions as allosteric regulators of calmodulin.

1985 • 90 citations

Depletion of Intracellular Zinc Induces Protein Synthesis-Dependent Neuronal Apoptosis in Mouse Cortical Culture

1998 • 88 citations

Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells.

2001 • 85 citations

Chelation and Intercalation: Complementary Properties in a Compound for the Treatment of Alzheimer's Disease

2000 • 82 citations

Mechanism of Nitrogen Excitation in the Night Sky

1939 • 79 citations

Zinc and the central nervous system.

1987 • 60 citations

Zinc metallochemistry in biochemistry

1995 • 60 citations

Distribution of terminal fields stained for zinc in the neocortex of the rat

1996 • 55 citations

Depletion of intracellular zinc induces macromolecule synthesis- and caspase-dependent apoptosis of cultured retinal cells

2000 • 50 citations

The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles

1991 • 46 citations

Induction by Synaptic Zinc of Heat Shock Protein-70 in Hippocampus after Kainate Seizures

2000 • 37 citations

Free zinc increases at the site of injury after cortical stab wounds in mature but not immature rat brain

1999 • 26 citations

The Importance of Zinc and Metallothionein in Brain

1994 • 16 citations