Depletion of Intracellular Zinc Induces Protein Synthesis-Dependent Neuronal Apoptosis in Mouse Cortical Culture

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Zinc coordination, function, and structure of zinc enzymes and other proteins

1990 • 1,731 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

The molecular biology of apoptosis.

1996 • 963 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?

1996 • 613 citations

Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

1997 • 486 citations

Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study

1985 • 410 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

The molecular biology of apoptoseis.

1996 • 390 citations

Potentiated Necrosis of Cultured Cortical Neurons by Neurotrophins

1995 • 360 citations

Oral Zinc in Macular Degeneration

1988 • 350 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat

1990 • 303 citations

AMPA receptor activation potentiates zinc neurotoxicity

1993 • 280 citations

Staurosporine-Induced Neuronal Apoptosis

1995 • 248 citations

Zinc neurotoxicity in cortical cell culture

1988 • 244 citations

Chapter 6 Zinc-containing neurons in hippocampus and related CNS structures

1990 • 238 citations

New perspective on zinc biochemistry: Cocatalytic sites in multi-zinc enzymes

1993 • 238 citations

Zinc-Containing Neurons

1994 • 224 citations

Reduction of delayed neuronal death by inhibition of protein synthesis

1990 • 190 citations

Chelation of intracellular zinc triggers apoptosis in mature thymocytes.

1993 • 180 citations

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

1995 • 171 citations

Zinc and Alzheimer's disease: is there a direct link?

1997 • 169 citations

Internucleosomal DNA Cleavage Involved in Ischemia-Induced Neuronal Death

1993 • 139 citations

Zinc‐Induced Aggregation of Human and Rat β‐Amyloid Peptides In Vitro

1996 • 131 citations

Hippocampal tin, aluminum and zinc in Alzheimer's disease

1993 • 125 citations

Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists

1992 • 117 citations

Apoptosis associated DNA fragmentation in epileptic brain damage

1994 • 114 citations

Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency

1991 • 111 citations

3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons

1995 • 111 citations

Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia

1995 • 74 citations

Apoptosis in the small intestine of zincdeficient and fasted rats

1977 • 72 citations

Selective Aggregation of Endogenous β‐Amyloid Peptide and Soluble Amyloid Precursor Protein in Cerebrospinal Fluid by Zinc

1997 • 54 citations

Subtle Neuronal Death in Striatum After Short Forebrain Ischemia in Rats Detected by In Situ End-Labeling for DNA Damage

1997 • 47 citations

Increased Superoxide Dismutase Activity Improves Survival of Cultured Postnatal Midbrain Neurons

1996 • 46 citations

The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles

1991 • 46 citations

Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia

1994 • 36 citations

Lack of Ca2+ involvement in thymocyte apoptosis induced by chelation of intracellular Zn2+.

1995 • 34 citations

Serum zinc levels in retinitis pigmentosa

1984 • 15 citations