STAT6 Is Required for the Anti-inflammatory Activity of Interleukin-4 in Mouse Peritoneal Macrophages

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Current protocols in molecular biology

1988 • 4,543 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

STATs and Gene Regulation

1997 • 3,927 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate

1992 • 1,144 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

1981 • 646 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

1997 • 428 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.

1989 • 421 citations

Synergy between Interferon-γ and Tumor Necrosis Factor-α in Transcriptional Activation Is Mediated by Cooperation between Signal Transducer and Activator of Transcription 1 and Nuclear Factor κB

1997 • 410 citations

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

1992 • 324 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.

1990 • 302 citations

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

1996 • 279 citations

A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter.

1993 • 256 citations

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

1993 • 256 citations

IL-4 inhibits the expression of IL-8 from stimulated human monocytes.

1990 • 244 citations

Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.

1996 • 243 citations

Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter.

1993 • 242 citations

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

1995 • 201 citations

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.

1993 • 193 citations

STF-IL-4: a novel IL-4-induced signal transducing factor.

1994 • 183 citations

Interleukin-4 Suppression of Tumor Necrosis Factor α-stimulated E-selectin Gene Transcription Is Mediated by STAT6 Antagonism of NF-κB

1997 • 149 citations

IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes.

1992 • 143 citations

IL-4 decreases Fc gamma R membrane expression and Fc gamma R-mediated cytotoxic activity of human monocytes.

1990 • 134 citations

Heterogeneity of Hematopoietic Cells Immortalized by v-myc/v-raf Recombinant Retrovirus Infection of Bone Marrow or Fetal Liver

1989 • 132 citations

Allergy‐associated Iϵ and Fcϵ receptor II (CD23b) genes activated via binding of an interleukin‐4‐induced transcription factor to a novel responsive element

1993 • 121 citations

Interleukin-4 and -13 Inhibit Tumor Necrosis Factor-α mRNA Translational Activation in Lipopolysaccharide-induced Mouse Macrophages

1997 • 111 citations

Interleukin-4-induced STAT6 Recognizes and Activates a Target Site in the Promoter of the Interleukin-4 Receptor Gene

1996 • 110 citations

IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophages.

1992 • 110 citations

IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4.

1991 • 102 citations

Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines.

1996 • 100 citations

IFN-gamma selectively inhibits lipopolysaccharide-inducible JE/monocyte chemoattractant protein-1 and KC/GRO/melanoma growth-stimulating activity gene expression in mouse peritoneal macrophages.

1994 • 99 citations

A unique palindromic element mediates gamma interferon induction of mig gene expression.

1994 • 96 citations

Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts.

1993 • 93 citations

Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo.

1993 • 91 citations

IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6.

1996 • 88 citations

5' regulatory region of a novel cytokine gene mediates selective activation by interferon gamma.

1991 • 85 citations

IL-4 up-regulates IL-1 receptor antagonist gene expression and its production in human blood monocytes.

1992 • 74 citations

IL-4 attenuates the transcriptional activation of both IFN-alpha and IFN-gamma-induced cellular gene expression in monocytes and monocytic cell lines.

1993 • 58 citations

Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line. Evidence for the involvement of Janus kinase 3 and interleukin-4 Stat.

1995 • 55 citations

Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes

1995 • 53 citations

Interleukin-4 inhibits the lipopolysaccharide-induced expression of c- jun and c-fos messenger RNA and activator protein-1 binding activity in human monocytes

1993 • 52 citations

Pathophysiological roles of cytokines in development, immunity, and inflammation ¹

1994 • 51 citations

Interleukin‐4 inhibits χ light chain expression and NFχB activation but not IχBα degradation in 70Z/3 murine pre‐B cells

1995 • 40 citations

Kappa B binding activity in a murine macrophage-like cell line. Sequence-specific differences in kappa B binding and transcriptional activation functions

1994 • 37 citations

Regulation of macrophage gene expression by T-cell-derived lymphokines

1994 • 37 citations

Mechanisms of IL-4-mediated suppression of IP-10 gene expression in murine macrophages.

1994 • 37 citations

11–4 Decreases IFN‐γ‐Induced Endothelial ICAM‐1 Expression by a Transcriptional Mechanism

1992 • 33 citations

IL-4 activates a latent DNA-binding factor that binds a shared IFN-gamma and IL-4 response element present in the germ-line gamma 1 Ig promoter.

1995 • 27 citations

A rapid method for generating linker scanning mutants utilizing PCR.

1993 • 20 citations

LPS Does Not Directly Induce STAT Activity in Mouse Macrophages

1996 • 11 citations