Fusion of epithelial cells by Epstein–Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins αvβ6 or αvβ8

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Structural Basis of Integrin Regulation and Signaling

2007 • 1,575 citations

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

2002 • 701 citations

Herpesvirus Entry: an Update

2003 • 570 citations

Conformational Regulation of Integrin Structure and Function

2002 • 536 citations

Expression of the β6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling

1995 • 470 citations

Alternate replication in B cells and epithelial cells switches tropism of Epstein–Barr virus

2002 • 445 citations

Epstein-Barr Virus Entry

2007 • 290 citations

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

1990 • 285 citations

Role of α _v Integrins in Adenovirus Cell Entry and Gene Delivery

1999 • 264 citations

Genetic and epigenetic changes in nasopharyngeal carcinoma

2002 • 262 citations

Epstein-Barr Virus gH Is Essential for Penetration of B Cells but Also Plays a Role in Attachment of Virus to Epithelial Cells

2000 • 262 citations

Integrin αvβ3 is a coreceptor for human cytomegalovirus

2005 • 253 citations

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.

1994 • 250 citations

Cell integrins: commonly used receptors for diverse viral pathogens

2007 • 216 citations

The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells

1995 • 193 citations

Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B

2007 • 174 citations

Epstein-Barr Virus Uses Different Complexes of Glycoproteins gH and gL To Infect B Lymphocytes and Epithelial Cells

1998 • 173 citations

Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis.

1995 • 164 citations

Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Envelope Glycoprotein gB Induces the Integrin-Dependent Focal Adhesion Kinase-Src-Phosphatidylinositol 3-Kinase-Rho GTPase Signal Pathways and Cytoskeletal Rearrangements

2004 • 154 citations

αvβ6 integrin in wound healing and cancer of the oral cavity

2005 • 149 citations

Functions of Pulmonary Epithelial Integrins: From Development to Disease

2003 • 141 citations

A Rearranged Form of Epstein–Barr Virus DNA Is Associated with Idiopathic Pulmonary Fibrosis

2002 • 130 citations

Complete Nucleotide Sequence of the Rhesus Lymphocryptovirus: Genetic Validation for an Epstein-Barr Virus Animal Model

2002 • 123 citations

Specificity of the VP1 GH Loop of Foot-and-Mouth Disease Virus for αv Integrins

2006 • 122 citations

Herpes simplex virus type 1 glycoprotein H binds to αvβ3 integrins

2004 • 102 citations

Involvement of Epstein-Barr virus latent membrane protein 1 in disease progression in patients with idiopathic pulmonary fibrosis

2000 • 99 citations

Complete Genomic Sequence of an Epstein-Barr Virus-Related Herpesvirus Naturally Infecting a New World Primate: a Defining Point in the Evolution of Oncogenic Lymphocryptoviruses

2002 • 98 citations

Transforming Growth Factor Beta 1 Stimulates Expression of the Epstein-Barr Virus BZLF1 Immediate-Early Gene Product ZEBRA by an Indirect Mechanism Which Requires the MAPK Kinase Pathway

2000 • 87 citations

Site-directed and linker insertion mutagenesis of herpes simplex virus type 1 glycoprotein H

1997 • 81 citations

Use of gHgL for Attachment of Epstein-Barr Virus to Epithelial Cells Compromises Infection

2004 • 70 citations

The Amino Terminus of Epstein-Barr Virus Glycoprotein gH Is Important for Fusion with Epithelial and B Cells

2005 • 65 citations

Epstein-Barr Virus BZLF1 Gene Is Activated by Transforming Growth Factor-β through Cooperativity of Smads and c-Jun/c-Fos Proteins

2002 • 65 citations

Endogenous TGF‐β contributes to the induction of the EBV lytic cycle in two burkitt lymphoma cell lines

1994 • 60 citations

Antibodies to gp350/220 Enhance the Ability of Epstein-Barr Virus To Infect Epithelial Cells

2006 • 56 citations

Interactions of Foot-and-Mouth Disease Virus with Soluble Bovine α _V β ₃ and α _V β ₆ Integrins

2004 • 53 citations

Mutations of Epstein-Barr Virus gH That Are Differentially Able To Support Fusion with B Cells or Epithelial Cells

2005 • 53 citations

Binding-Site Interactions between Epstein-Barr Virus Fusion Proteins gp42 and gH/gL Reveal a Peptide That Inhibits both Epithelial and B-Cell Membrane Fusion

2007 • 53 citations

Induction of antibodies to the Epstein-Barr virus glycoprotein gp85 with a synthetic peptide corresponding to a sequence in the BXLF2 open reading frame

1988 • 51 citations

Characterization of the Epstein–Barr virus glycoprotein BMRF-2

2006 • 45 citations

Mutational Analyses of Epstein-Barr Virus Glycoprotein 42 Reveal Functional Domains Not Involved in Receptor Binding but Required for Membrane Fusion

2004 • 45 citations

Epstein–Barr Virus Lacking Glycoprotein gp85 Cannot Infect B Cells and Epithelial Cells

2000 • 45 citations

Laser‐capture microdissection of oropharyngeal epithelium indicates restriction of Epstein–Barr virus receptor/CD21 mRNA to tonsil epithelial cells

2008 • 37 citations

Length of Epstein-Barr Virus Termini as a Determinant of Epithelial Cell Clonal Emergence

2003 • 35 citations

Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusion

2007 • 34 citations

Airway Epithelial Integrins: Why So Many?

1998 • 28 citations

Co-expression of the Epstein--Barr virus BXLF2 and BKRF2 genes with a recombinant baculovirus produces gp85 on the cell surface with antigenic similarity to the native protein

1995 • 19 citations

A 50-Å Separation of the Integrin αvβ3 Extracellular Domain C Termini Reveals an Intermediate Activation State

2004 • 6 citations