A 50-Å Separation of the Integrin αvβ3 Extracellular Domain C Termini Reveals an Intermediate Activation State

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

2002 • 1,134 citations

Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

2003 • 784 citations

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

2002 • 701 citations

Breaking the Integrin Hinge

1996 • 567 citations

A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face

2002 • 511 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Structure of integrin 5 1 in complex with fibronectin

2003 • 332 citations

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

1990 • 328 citations

Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations

2003 • 285 citations

Crystal Structure of Alkaline Phosphatase from Human Placenta at 1.8 Å Resolution

2001 • 256 citations

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.

2001 • 255 citations

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.

1994 • 250 citations

Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activityin vivo

2001 • 214 citations

Topography of Ligand-induced Binding Sites, Including a Novel Cation-sensitive Epitope (AP5) at the Amino Terminus, of the Human Integrin β3 Subunit

1995 • 169 citations

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

2003 • 146 citations

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble

2003 • 134 citations

Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.

1994 • 122 citations

Structure of an Integrin-Ligand Complex Deduced from Solution X-ray Scattering and Site-directed Mutagenesis

2003 • 102 citations

Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides

2004 • 86 citations

Transmembrane-truncated αvβ3 integrin retains high affinity for ligand binding: evidence for an ‘inside-out’ suppressor?

1998 • 76 citations

Synergistic action of two murine monoclonal antibodies that inhibit ADP- induced platelet aggregation without blocking fibrinogen binding

1987 • 50 citations

Synergistic action of two murine monoclonal antibodies that inhibit ADP- induced platelet aggregation without blocking fibrinogen binding

1987 • 33 citations