Transforming Growth Factor Beta 1 Stimulates Expression of the Epstein-Barr Virus BZLF1 Immediate-Early Gene Product ZEBRA by an Indirect Mechanism Which Requires the MAPK Kinase Pathway

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

Epstein-Barr Virus

1986 • 2,255 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

A simple phase-extraction assay for chloramphenicol acyltransferase activity

1988 • 1,006 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Persisting oncogenic herpesvirus induced by the tumour promoter TPA

1978 • 632 citations

Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA.

1985 • 454 citations

Epstein-Barr Virus (EBV) Induced Polyclonal and Monoclonal B-Cell Lymphoproliferative Diseases Occurring after Renal Transplantation

1983 • 427 citations

EPSTEIN-BARR VIRUS, IMMUNODEFICIENCY, AND B CELL LYMPHOPROLIFERATION

1985 • 416 citations

Transforming growth factor-beta: a general review.

1996 • 400 citations

Defective Regulation of Epstein–Barr Virus Infection in Patients with Acquired Immunodeficiency Syndrome (AIDS) or AIDS-Related Disorders

1986 • 384 citations

Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter.

1986 • 359 citations

Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption

1998 • 322 citations

Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1

1990 • 249 citations

Activation of p21ras by transforming growth factor beta in epithelial cells.

1992 • 223 citations

The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions

1990 • 205 citations

The Epstein-Barr virus Zta transactivator: a member of the bZIP family with unique DNA-binding specificity and a dimerization domain that lacks the characteristic heptad leucine zipper motif

1990 • 199 citations

Activation of the Hematopoietic Progenitor Kinase-1 (HPK1)-dependent, Stress-activated c-Jun N-terminal Kinase (JNK) Pathway by Transforming Growth Factor β (TGF-β)-activated Kinase (TAK1), a Kinase Mediator of TGF β Signal Transduction

1997 • 193 citations

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene ( COL 7A1 ) promoter by transforming growth factor β

1998 • 178 citations

Activation of latent Epstein–Barr virus by antibody to human IgM

1978 • 169 citations

Identification of phorbol ester response elements in the promoter of Epstein-Barr virus putative lytic switch gene BZLF1

1990 • 164 citations

Induction of Apoptosis by DPC4, a Transcriptional Factor Regulated by Transforming Growth Factor-β through Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) Signaling Pathway

1997 • 164 citations

p38 Mitogen-Activated Protein Kinase Can Be Involved in Transforming Growth Factor β Superfamily Signal Transduction in Drosophila Wing Morphogenesis

1999 • 164 citations

The Epstein-Barr virus early protein EB1 activates transcription from different responsive elements including AP-1 binding sites.

1989 • 157 citations

Activation of a Ras–MAPK-Dependent Pathway by Epstein–Barr Virus Latent Membrane Protein 1 Is Essential for Cellular Transformation

1998 • 144 citations

Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-β1 involves activation of protein kinase C

1995 • 133 citations

Epstein-Barr virus bicistronic mRNAs generated by facultative splicing code for two transcriptional trans-activators.

1989 • 133 citations

Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6

1993 • 119 citations

Calcium Modulation Activates Epstein-Barr Virus Genome in Latently Infected Cells

1986 • 116 citations

The Role of p38 MAP Kinase in TGF-β1-Induced Signal Transduction in Human Neutrophils

1998 • 107 citations

Qualitative analysis of the expression of Epstein--Barr virus lytic genes in nasopharyngeal carcinoma biopsies

1995 • 105 citations

Identification of cellular target genes of the Epstein-Barr virus transactivator Zta: activation of transforming growth factor beta igh3 (TGF-beta igh3) and TGF-beta 1

1995 • 100 citations

Autoinduction of Transforming Growth Factor β1 Is Mediated by the AP-1 Complex

1990 • 99 citations

Regulation of protein kinase C isoform proteins in phorbol ester-stimulated Jurkat T lymphoma cells.

1993 • 97 citations

Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester.

1990 • 89 citations

Evidence for Involvement of Phosphatidylcholine-Phospholipase C and Protein Kinase C in Transforming Growth Factor-β Signaling

1995 • 88 citations

In vitro analysis of the epstein‐barr virus: Host balance in long‐term renal allograft recipients

1985 • 86 citations

Transforming growth factor beta and epidermal growth factor alter calcium influx and phosphatidylinositol turnover in rat-1 fibroblasts.

1988 • 76 citations

Epstein-Barr virus induction by a serum factor I. Induction and cooperation with additional inducers

1982 • 75 citations

L-428 nodular sclerosing Hodgkin's cell secretes a unique transforming growth factor-beta active at physiologic pH.

1988 • 69 citations

Induction of Epstein-Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C

1991 • 65 citations

Transforming Growth Factor-β1-Induced Activation of the Raf-MEK-MAPK Signaling Pathway in Rat Lung Fibroblasts via a PKC-Dependent Mechanism

1998 • 65 citations

Regulation of the BZLF1 Promoter of Epstein-Barr Virus by Second Messengers in Anti-immunoglobulin-Treated B Cells

1994 • 64 citations

Endogenous TGF‐β contributes to the induction of the EBV lytic cycle in two burkitt lymphoma cell lines

1994 • 60 citations

Abundant expression of transforming growth factor-β1 and -β2 by Hodgkin's reed-sternberg cells and by reactive T lymphocytes in Hodgkin's disease

1993 • 55 citations

Characterization of the ZI domains in the Epstein-Barr virus BZLF1 gene promoter: role in phorbol ester induction

1996 • 54 citations

Regulation of transforming growth factor beta 1 action by multiple transducing pathways: evidence for both G protein-dependent and -independent signaling.

1989 • 50 citations

Signaling events initiated by transforming growth factor-beta 1 that require Gi alpha 1.

1993 • 43 citations

TPA-inducible Epstein-Barr virus genes in Raji cells and their regulation

1988 • 40 citations

The human l_α1 and l_α2 germline promoter elements: proximal positive and distal negative elements may regulate the tissue specific expression of C_α1 and C_α2 germline transcripts

1993 • 39 citations

Evidence for c‐myc in the signaling pathway for TGF‐β in well‐differentiated human colon carcinoma cells

1990 • 33 citations

Divergent Requirements for the MAPK^ERKSignal Transduction Pathway during Initial Virus Infection of Quiescent Primary B Cells and Disruption of Epstein-Barr Virus Latency by Phorbol Esters

1999 • 33 citations

Binding of the Epstein-Barr virus to human platelets causes the release of transforming growth factor-beta.

1997 • 33 citations

Advances in the diagnosis and treatment of EBV‐associated lymphoproliferative diseases in immunocompromised hosts

1985 • 27 citations

The interaction of mitogen-activated protein kinases to Epstein-Barr virus activation in Akata cells.

1999 • 27 citations

Lack of the expression of EBNA-2 and LMP-1 in T-cell neoplasms possessing Epstein-Barr virus

1995 • 26 citations

Antagonistic action of RU38486 on the activity of transforming growth factor-β in fibroblasts and lymphoma cells

1988 • 20 citations

REGULATION BY PROTEIN KINASE C OF TRANSFORMING GROWTH FACTOR‐β₁ ACTION ON THE PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS FROM SPONTANEOUSLY HYPERTENSIVE RATS

1996 • 14 citations

Evidence for clonal heterogeneity of the expression of six protein kinase C isoforms in murine B and T lymphocytes

1992 • 13 citations