Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein

2000 • 739 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

Leukocyte polarization in cell migration and immune interactions

1999 • 622 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI

2000 • 494 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue

1997 • 487 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages

1999 • 422 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

1999 • 397 citations

Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes

1999 • 367 citations

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

1993 • 316 citations

The Arp2/3 complex: a multifunctional actin organizer

1999 • 314 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

Chemotaxis of macrophages is abolished in the Wiskott‐Aldrich syndrome

1998 • 241 citations

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells.

1991 • 241 citations

Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue

1998 • 214 citations

Protein prenylation: more than just glue?

1992 • 208 citations

Defective Actin Reorganization and Polymerization of Wiskott-Aldrich T Cells in Response to CD3-Mediated Stimulation

1997 • 206 citations

Monoclonal antibodies to murine CD40 define two distinct functional epitopes

1994 • 152 citations

Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine.

1998 • 144 citations

Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome

1986 • 143 citations

T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome.

1992 • 141 citations

Monocytes from Wiskott-Aldrich Patients Display Reduced Chemotaxis and Lack of Cell Polarization in Response to Monocyte Chemoattractant Protein-1 and Formyl-Methionyl-Leucyl-Phenylalanine

1998 • 134 citations

Characterization of the physical interaction between antigen-specific B and T cells.

1986 • 124 citations

Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome

1998 • 123 citations

Two Pathways through Cdc42 Couple the N-Formyl Receptor to Actin Nucleation in Permeabilized Human Neutrophils

2000 • 116 citations

Tyrosine phosphorylation of the Wiskott‐Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42

1998 • 111 citations

Characterization of the Interactions between the Small GTPase Cdc42 and Its GTPase-activating Proteins and Putative Effectors

1997 • 99 citations

Distinctive characteristics of germinal center B cells

1997 • 96 citations

Untying the Gordian Knot of Cytokinesis

2000 • 69 citations

Novel mutations in the Wiskott-Aldrich syndrome protein gene and their effects on transcriptional, translational, and clinical phenotypes

1999 • 67 citations

IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes

2000 • 64 citations

Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome

1998 • 57 citations

The Mouse Homolog of the Wiskott–Aldrich Syndrome Protein (WASP) Gene Is Highly Conserved and Maps near the Scurfy (sf) Mutation on the X Chromosome

1995 • 46 citations

Regulation of Cell Morphology in B Lymphocytes by IL-4: Evidence for Induced Cytoskeletal Changes

1998 • 45 citations

Is Wiskott–Aldrich syndrome a cell trafficking disorder?

1998 • 44 citations

CD44‐stimulated dendrite formation (‘spreading’) in activated B cells

1997 • 39 citations

CD4+ T Cell Responses to CD40-Deficient APCs: Defects in Proliferation and Negative Selection Apply Only with B Cells as APCs

1999 • 36 citations

Inhibition of LFA-1-dependent human B-cell aggregation induced by CD40 antibodies and interleukin-4 leads to decreased IgE synthesis.

1993 • 31 citations

Interleukin 4 enhances the ability of antigen-specific B cells to form conjugates with T cells.

1987 • 31 citations

Recombinant IL-4 and IFN-gamma activate locomotor capacity in human B lymphocytes.

1989 • 30 citations

STAT6 is required for the regulation of IL-4-induced cytoskeletal events in B cells

2000 • 28 citations

T and B cell collaboration: induction of motility in small, resting B cells by interleukin 4

1991 • 24 citations

Interactions between IL-4, anti-CD40, and anti-immunoglobulin as activators of locomotion of human B cells.

1995 • 22 citations

Methods for phenotyping polarized and locomotor human lymphocytes

1992 • 21 citations

Homotypic aggregation of murine B lymphocytes is independent of CD23

1995 • 20 citations

Interleukin 4 Induces Cellular Adhesion Among B Lymphocytes

1989 • 18 citations

Assessment of the Role of Leucocyte Function‐Associated Antigen‐1 in Homotypic Adhesion of Activated B Lymphocytes

1998 • 17 citations

Germinal centers: Getting there is half the fun

1998 • 13 citations

Characterization of Pgp-1 Antigen on Murine B Lymphocytes Using a New Anti-Pgp-1 Monoclonal Antibody

1991 • 7 citations