Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

1994 • 1,053 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

A multiinstitutional survey of the Wiskott-Aldrich syndrome

1994 • 612 citations

PEDIGREE DEMONSTRATING A SEX-LINKED RECESSIVE CONDITION CHARACTERIZED BY DRAINING EARS, ECZEMATOID DERMATITIS AND BLOODY DIARRHEA

1954 • 512 citations

Wiskott-Aldrich syndrome

1968 • 422 citations

The structure and function of α-actinin

1989 • 421 citations

The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets

1980 • 327 citations

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

1995 • 325 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin.

1992 • 309 citations

X–linked thrombocytopenia and Wiskott–Aldrich syndrome are allelic diseases with mutations in the WASP gene

1995 • 284 citations

T cell independent antigens

1995 • 282 citations

Bee1, a Yeast Protein with Homology to Wiscott-Aldrich Syndrome Protein, Is Critical for the Assembly of Cortical Actin Cytoskeleton

1997 • 252 citations

The specific direct interaction of helper T cells and antigen-presenting B cells.

1986 • 246 citations

Actin dynamics in vivo

1997 • 239 citations

The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene

1995 • 211 citations

Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP.

1995 • 208 citations

T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses.

1993 • 197 citations

Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.

1993 • 187 citations

The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: receptor positioning in microvilli does not require interaction with alpha-actinin.

1995 • 177 citations

Actin-binding proteins

1990 • 164 citations

Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases

1996 • 154 citations

Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome

1986 • 143 citations

Actin

1990 • 142 citations

T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome.

1992 • 141 citations

Studies of the expression of the Wiskott-Aldrich syndrome protein.

1996 • 131 citations

Ligand-induced association of surface immunoglobulin with the detergent-insoluble cytoskeletal matrix of the B lymphocyte.

1982 • 124 citations

Defects in Wiskott-Aldrich syndrome blood cells

1996 • 122 citations

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.

1996 • 109 citations

Molecular Cloning, Splice Variants, Expression, and Purification of Phospholipase C-δ;4

1996 • 106 citations

Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome.

1992 • 91 citations

WASPbase: a database of WAS- and XLT-causing mutations

1996 • 89 citations

Proteolytic cleavage of alpha-actinin by calpain in T cells stimulated with anti-CD3 monoclonal antibody.

1996 • 78 citations

High prevalence of nonsense, frame shift, and splice-site mutations in 16 patients with full-blown Wiskott-Aldrich syndrome

1995 • 72 citations

Identification of Regions of the Wiskott-Aldrich Syndrome Protein Responsible for Association with Selected Src Homology 3 Domains

1996 • 71 citations

The structure of the F-actin filament and the actin molecule

1992 • 67 citations

In Vitro Reconstitution of Cortical Actin Assembly Sites in Budding Yeast

1997 • 62 citations

Hereditary X-linked thrombocytopenia maps to the same chromosomal region as the Wiskott-Aldrich syndrome

1988 • 60 citations

Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients.

1997 • 52 citations

Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes.

1991 • 48 citations

Scanning of the Wiskott-Aldrich syndrome (WAS) gene: identification of 18 novel alterations including a possible mutation hotspot at Arg86 resulting in thrombocytopenia, a mild WAS phenotype

1995 • 47 citations

Membrane Ig-cytoskeletal interactions. I. Flow cytofluorometric and biochemical analysis of membrane IgM-cytoskeletal interactions.

1988 • 36 citations

A PCR-based non-radioactive X-chromosome inactivation assay for genetic counseling in X-linked primary immunodeficiencies

1997 • 33 citations

Ligand-induced association of surface immunoglobulin with the detergent insoluble cytoskeleton may involve alpha-actinin.

1988 • 25 citations

Wiskott-Aldrich syndrome and related X-linked thrombocytopenia

1990 • 18 citations

The Many Faces of WAS Protein

1997 • 14 citations