p53 from complexity to simplicity: mutant p53 stabilization, gain‐of‐function, and dominant‐negative effect

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Prion Protein Biology

1998 • 913 citations

Gain of function mutations in p53

1993 • 876 citations

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

1997 • 872 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Pharmacological Rescue of Mutant p53 Conformation and Function

1999 • 794 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

The cellular response to p53: the decision between life and death

1999 • 594 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

P53, cell cycle control and apoptosis: Implications for cancer

1995 • 467 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Identification and classification of p53-regulated genes

1999 • 460 citations

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a

1999 • 453 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

1991 • 391 citations

Molecular effects of paclitaxel: Myths and reality (a critical review)

1999 • 356 citations

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma.

1975 • 353 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding

1997 • 315 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1995 • 291 citations

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

1998 • 286 citations

p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription

1998 • 284 citations

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

1996 • 283 citations

Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function

1996 • 271 citations

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

1998 • 241 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Proteasome-Dependent Regulation of p21WAF1/CIP1Expression

1996 • 223 citations

p53: the ultimate tumor suppressor gene?

1992 • 209 citations

Cancer therapy and p53

1995 • 194 citations

Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest

1998 • 186 citations

p53 is a general repressor of RNA polymerase III transcription

1998 • 182 citations

Inhibition of viral and cellular promoters by human wild-type p53

1992 • 178 citations

Dominant-negative p53 mutations selected in yeast hit cancer hot spots.

1996 • 160 citations

p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.

1998 • 158 citations

mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.

1998 • 153 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract

1999 • 151 citations

Loss of function and p53 protein stabilization

1997 • 135 citations

Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines.

1994 • 133 citations

MDM2-arbiter of p53's destruction

1997 • 127 citations

Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

2000 • 108 citations

Depletion of p185 erbB2 , Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

1997 • 104 citations

The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

1999 • 101 citations

Flexibility: the key to p53 function?

1995 • 87 citations

In vitro analysis of the dominant negative effect of p53 mutants

1998 • 74 citations

Suppression of the p300-dependent mdm2negative-feedback loop induces the p53 apoptotic function

1998 • 74 citations

Wild-type and mutant forms of p53 activate human topoisomerase I: a possible mechanism for gain of function in mutants.

1998 • 72 citations

Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains

1999 • 71 citations

Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme.

1999 • 67 citations

Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer

2000 • 63 citations

One Mechanism for Cell Type-specific Regulation of thebax Promoter by the Tumor Suppressor p53 Is Dictated by the p53 Response Element

1999 • 63 citations

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

1999 • 57 citations

Dosage‐dependent dominance over wild‐type p53 of a mutant p53 isolated from nasopharyngeal carcinoma ¹

1993 • 54 citations

Loss of heterozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas

1992 • 54 citations

Detection of both mutant and wild-type p53 protein in normal skin fibroblasts and demonstration of a shared 'second hit' on p53 in diverse tumors from a cancer-prone family with Li-Fraumeni syndrome.

1992 • 48 citations

Equal transcription of wild-type and mutant p53 using bicistronic vectors results in the wild-type phenotype.

1994 • 48 citations

p53 mediated apoptosis in HeLa cells: transcription dependent and independent mechanisms.

1997 • 47 citations

Overlapping domains on the p53 protein regulate its transcriptional activation and repression functions.

1994 • 45 citations

Inhibitors of Transcription, Proteasome Inhibitors, and DNA-Damaging Drugs Differentially Affect Feedback of p53 Degradation

1998 • 42 citations

p53 mutations isolated in yeast based on loss of transcription factor activity: similarities and differences from p53 mutations detected in human tumors

1998 • 38 citations

Hemi‐ or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenetic effect

1993 • 34 citations

Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation.

1995 • 22 citations

Tumour associated mutants of p53 can inhibit transcriptional activity of p53 without heterooligomerization

1998 • 21 citations

Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells.

1996 • 10 citations