In vitro analysis of the dominant negative effect of p53 mutants

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Thermodynamic stability of wild-type and mutant p53 core domain

1997 • 401 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1993 • 252 citations

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

1991 • 242 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

Activation of the cryptic DNA binding function of mutant forms of p53

1993 • 190 citations

Dominant-negative p53 mutations selected in yeast hit cancer hot spots.

1996 • 160 citations

Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences.

1993 • 110 citations

Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.

1995 • 101 citations

Specific DNA binding by different classes of human p53 mutants.

1995 • 81 citations

Mutations in p53 produce a common conformational effect that can be detected with a panel of monoclonal antibodies directed toward the central part of the p53 protein.

1994 • 72 citations

Restoration of the transcription activation function to mutant p53 in human cancer cells.

1996 • 66 citations

Novel DNA binding of p53 mutants and their role in transcriptional activation.

1993 • 65 citations

Analysis of p53 transactivation through high-affinity binding sites.

1993 • 37 citations

In vitro structure-function analysis of the β-strand 326-333 of human p53 1 1Edited by A. Fersht

1997 • 32 citations