In situ demonstration of phosphorylated c-jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skin

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Molecular basis of sun-induced premature skin ageing and retinoid antagonism

1996 • 1,379 citations

The p53 pathway

1999 • 1,322 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

The stress-activated protein kinase pathways

1999 • 648 citations

Transcriptional Cross Talk between NF-κB and p53

1999 • 590 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

1998 • 431 citations

Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo.

1998 • 379 citations

Changes in Keratinocyte Maturation During Wound Healing

1987 • 375 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

A Cytokine Cascade Including Prostaglandin E2, IL-4, and IL-10 Is Responsible for UV-Induced Systemic Immune Suppression

1998 • 351 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

Sunlight and the onset of skin cancer

1997 • 302 citations

Keratins (Kl6 and Kl7) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro

1995 • 291 citations

p38 Kinase Mediates UV-induced Phosphorylation of p53 Protein at Serine 389

1999 • 280 citations

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

1994 • 253 citations

Cell Density and Culture Factors Regulate Keratinocyte Commitment to Differentiation and Expression of Suprabasal K1/K10 Keratins

1995 • 242 citations

UVB Activates ERK1/2 and p38 Signaling Pathways via Reactive Oxygen Species in Cultured Keratinocytes

1999 • 239 citations

Central Role of Ferrous/Ferric Iron in the Ultraviolet B Irradiation-mediated Signaling Pathway Leading to Increased Interstitial Collagenase (Matrix-degrading Metalloprotease (MMP)-1) and Stromelysin-1 (MMP-3) mRNA Levels in Cultured Human Dermal Fibroblasts

1998 • 228 citations

Sequential DNA damage-independent and -dependent activation of NF-kappa B by UV

1998 • 225 citations

The Epidermis: Genes On – Genes Off

1997 • 181 citations

UVB Light Induces Nuclear Factor κB (NFκB) Activity Independently from Chromosomal DNA Damage in Cell-Free Cytosolic Extracts

1994 • 165 citations

Regulation of Human Involucrin Promoter Activity by a Protein Kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 Signal Transduction Pathway

1998 • 149 citations

Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia.

1996 • 142 citations

Activation of p38 Mitogen-Activated Protein Kinase and Caspases in UVB-Induced Apoptosis of Human Keratinocyte HaCaT Cells

1999 • 131 citations

Differential expression of the fos and jun family members c-fos, fosB, Fra-1, Fra-2, c-jun, junB and junD during human epidermal keratinocyte differentiation.

1995 • 121 citations

Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pre-treatment

1999 • 113 citations

Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide

1997 • 112 citations

Induction of SLPI (ALP/HUSI-I) in Epidermal Keratinocytes

1998 • 105 citations

Role of p53 in UVB-Induced Apoptosis in Human HaCaT Keratinocytes

1997 • 94 citations

Immunohistochemical Localization of SKALP/Elafin in Psoriatic Epidermis

1993 • 88 citations

TNF-α and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway

2000 • 86 citations

Relationship Between Ultraviolet Radiation-Induced Immunosuppression and Carcinogenesis

1994 • 83 citations

The p38MAPK Inhibitor SB203580 Alleviates Ultraviolet-Induced Phosphorylation at Serine 389 but Not Serine 15 and Activation of p53

1999 • 78 citations

Changes in expression of members of the fos and jun families and myc network during terminal differentiation of human keratinocytes.

1995 • 70 citations

Induction of normal and psoriatic phenotypes in submerged keratinocyte cultures

1996 • 67 citations

Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level.

1995 • 63 citations

Evidence for an Alternative Pathway of Keratinocyte Maturation in Psoriasis from an Antigen Found in Psoriatic but Not Normal Epidermis

1984 • 60 citations

Expression of SKALP/elafin during wound healing in human skin

1996 • 56 citations

Evidence that DNA Damage Is a Mediate in Ultraviolet B Radiation-Induced Inhibition of Human Gene Expression: Ultraviolet B Radiation Effects on Intercellular Adhesion Molecule-1 (ICAM-1) Expression

1994 • 45 citations

UVB Irradiation Alters Cellular Responses to Cytokines: Role in Extracellular Matrix Gene Expression

1997 • 32 citations

Rapid activation of JNK1 in UV-B irradiated epidermal keratinocytes

1998 • 31 citations

The effect of ultraviolet (UVB and PUVA) radiation on the expression of epidermal keratins

1993 • 29 citations

The role of cytokines in ultraviolet-B induced immunosuppression.

1997 • 26 citations

Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of the oesophagus

1997 • 24 citations

Re-expression of elafin in 21MT2 breast carcinomas by phorbol 12-myristate 13-acetate is mediated by the Ap1 site in the elafin promoter.

1997 • 20 citations

Effects of ultraviolet B radiation on cytoskeletal and adhesion molecules in human epidermis.

1994 • 20 citations

The inflammatory and proliferative response of normal skin in a model for acute chemical injury: ornithine decarboxylase induction as a common feature in various models for acute skin injury

1994 • 10 citations