A Novel Mechanism for B Cell Repertoire Maturation Based on Response by B Cell Precursors to Pre–B Receptor Assembly

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

1991 • 485 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

1995 • 363 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ

1987 • 293 citations

CD5 B Cells, a Fetal B Cell Lineage

1993 • 252 citations

The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

1994 • 238 citations

Increased Frequency of N-Region Insertion in a Murine Pre-B-Cell Line Infected with a Terminal Deoxynucleotidyl Transferase Retroviral Expression Vector

1987 • 214 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

1990 • 203 citations

A single VH gene is utilized predominantly in anti-BrMRBC hybridomas derived from purified Ly-1 B cells. Definition of the VH11 family.

1989 • 192 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone

1997 • 167 citations

The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice.

1989 • 164 citations

Distinctive Developmental Origins and Specificities of Murine CD5⁺ B Cells

1994 • 129 citations

Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector.

1987 • 125 citations

Surrogate light chain-dependent selection of Ig heavy chain V regions.

1995 • 101 citations

Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination

1993 • 90 citations

Expression of phosphorylcholine-specific B cells during murine development

1977 • 85 citations

Predominance of nonproductive rearrangements of VH81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains.

1991 • 71 citations

Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes.

1990 • 68 citations

Down-regulation of terminal deoxynucleotidyl transferase by Ig heavy chain in B lineage cells.

1997 • 61 citations

The Regulated Production of μ_m and μ_s mRNA Is Dependent on the Relative Efficiencies of μ_s Poly(A) Site Usage and the Cμ4-to-M1 Splice

1989 • 57 citations

Cellular Stages and Molecular Steps of Murine B-cell Development

1989 • 44 citations

The Clonotype Repertoire of B Cell Subpopulations

1988 • 42 citations

Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition.

1995 • 38 citations

Role of homology-directed recombination: Predominantly productive rearrangements of VH81X in newborns but not in adults

1993 • 30 citations

Development of B cells in scid mice with immunoglobulin transgenes: Implications for the Control of V(D)J recombination

1995 • 28 citations

Programmed Development of the Antibody Repertoire

1987 • 27 citations

V(H) repertoire maturation during B cell development in vitro: differential selection of Ig heavy chains by fetal and adult B cell progenitors.

1997 • 24 citations